Results 91 to 100 of about 1,677,383 (218)

Efficacy and safety of nintedanib in patients with advanced idiopathic pulmonary fibrosis

, 2020
Luca Richeldi, Martin Kolb, S. Jouneau, Wim Wuyts, Birgit Schinzel, Susanne Stowasser, Manuel Quaresma, Ganesh Raghu   +7 more
openalex   +1 more source

Pyroptosis-related signatures predict immune characteristics and prognosis in IPF

Heliyon
The purpose of this work was to use integrated bioinformatics analysis to screen for pyroptosis-related genes (PRGs) and possible immunological phenotypes linked to the development and course of IPF.
Yijun He, Tingting Yao, Yan Zhang, Lingzhi Long, Guoliang Jiang, Xiangyu Zhang, Xin Lv, Yuanyuan Han, Xiaoyun Cheng, Mengyu Li, Mao Jiang, Zhangzhe Peng, Lijian Tao, Jie Meng   +13 more
doaj   +1 more source

Mechanical stress-induced mast cell degranulation activates TGFβ-1 signalling pathway in pulmonary fibrosis [PDF]

, 2016
Chiko Shimbori, Pierre‐Simon Bellaye, Chandak Upagupta, Jack Gauldie, Martin Kolb   +4 more
openalex   +1 more source

The Thyroid Hormone Analog GC‐1 Mitigates Acute Lung Injury by Inhibiting M1 Macrophage Polarization

Advanced Science
Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a life‐threatening condition with a high mortality rate of ≈40%. Thyroid hormones (THs) play crucial roles in maintaining homeostasis of the cellular microenvironment under stress. The
Bin Li, Cong Xia, Wanyu He, Jingyi Liu, Ruoyu Duan, Zhihua Ji, Xiaoyue Pan, Yanlin Zhou, Guoying Yu, Lan Wang   +9 more
doaj   +1 more source

TRIM36 inhibits lung fibroblast activation and pulmonary fibrosis through the degradation of phospho-AKT1

iScience
Summary: The ubiquitin-proteasome system (UPS) critically regulates protein stability and function. E3 ligase dysregulation plays a crucial role in idiopathic pulmonary fibrosis (IPF). TRIM36, a RING-finger E3 ligase with emerging tumor-suppressive roles
Yajun Li, Yuexia Yang, Yingjie Wang, Feifan Shi, Yue Zhang, Hongzhi Wen, Xin Pan, Cong Xia, Zhongzheng Li, Kaisa Cui, Guojun Zhao, Huibing Liu, Qiwen Wang, Lan Wang, Guoying Yu   +14 more
doaj   +1 more source

Plasma levels of chemokines decrease during elexacaftor/tezacaftor/ivacaftor therapy in adults with cystic fibrosis

Heliyon
Background: Cystic fibrosis (CF) is associated with dysregulated immune responses, exaggerated inflammation and chronic infection. CF transmembrane conductance regulator (CFTR) modulator therapies directly target the underlying protein defects and ...
Dirk Westhölter, Johannes Pipping, Jonas Raspe, Mona Schmitz, Sivagurunathan Sutharsan, Svenja Straßburg, Matthias Welsner, Christian Taube, Sebastian Reuter   +8 more
doaj   +1 more source

Real-World Clinical Effectiveness and Safety of Antifibrotics in Progressive Pulmonary Fibrosis Associated with Rheumatoid Arthritis [PDF]

Javier Narváez, Martí Aguilar-Coll, Vanesa Vicens‐Zygmunt, Juan José Alegre Sancho, Guadalupe Bermudo, María Molina‐Molina   +5 more
openalex   +1 more source

Clinical implications of interstitial pneumonia with autoimmune features diagnostic criteria in idiopathic pulmonary fibrosis: A case control study

, 2023
Sara Tomassetti, Claudia Ravaglia, Silvia Puglisi, Athol U. Wells, Jay H. Ryu, Marcello Bosi, Alessandra Dubini, Sara Piciucchi, Francesco Girelli, Paola Parronchi, Federico Lavorini, Elisabetta Rosi, Valentina Luzzi, Marco Matucci‐Cerinic, Venerino Poletti   +14 more
openalex   +1 more source

Succinate promotes pulmonary fibrosis through GPR91 and predicts death in idiopathic pulmonary fibrosis

Scientific Reports
Idiopathic pulmonary fibrosis (IPF) is believed to be associated with a notable disruption of cellular energy metabolism. By detecting the changes of energy metabolites in the serum of patients with pulmonary fibrosis, we aimed to investigate the ...
Yijun He, Yuanyuan Han, Lijun Zou, Tingting Yao, Yan Zhang, Xin Lv, Mao Jiang, Lingzhi Long, Mengyu Li, Xiaoyun Cheng, Guoliang Jiang, Zhangzhe Peng, Lijian Tao, Jie Meng, Wei Xie   +14 more
doaj   +1 more source

RNA-seq reproducibility of Pseudomonas aeruginosa in laboratory models of cystic fibrosis

Microbiology Spectrum
Reproducibility is a fundamental expectation in science and enables investigators to have confidence in their research findings and the ability to compare data from disparate sources, but evaluating reproducibility can be elusive. For example, generating
Rebecca P. Duncan, Gina R. Lewin, Daniel M. Cornforth, Frances L. Diggle, Ananya Kapur, Dina A. Moustafa, Yasmin Hilliam, Jennifer M. Bomberger, Marvin Whiteley, Joanna B. Goldberg   +9 more
doaj   +1 more source