Results 91 to 100 of about 386,415 (318)

Increased expression of 5-hydroxytryptamine(2A/B) receptors in idiopathic pulmonary fibrosis: a rationale for therapeutic intervention [PDF]

, 2010
Background Idiopathic pulmonary fibrosis (IPF) has a poor prognosis and limited responsiveness to available treatments. It is characterised by epithelial cell injury, fibroblast activation and proliferation and extracellular matrix deposition ...
Amarie, Oana Veronica, Dumitrascu, Rio, Eickelberg, Oliver, Grimminger, Friedrich, Königshoff, Melanie, Reiter, Rudolf, Schermuly, Ralph Theo, Seeger, Werner, Udalov, Sergey   +8 more
core   +1 more source

Recent Advances in mRNA Delivery Systems for Cancer Therapy

Advanced Science, EarlyView.
This review systematically investigates the applications of mRNA therapy in cancer treatment, with particular emphasis on nonviral delivery systems, targeting strategies, stimulus‐responsive systems, and local delivery methods. Concluding with a meticulous evaluation, the review sheds light on the prevailing challenges while illuminating promising ...
Zheng Zhang, Ya‐Nan Fan, Si‐Qi Jiang, Ya‐Jing Ma, Yao‐Ru Yu, Yu‐Xin Qing, Qian‐Ru Li, Yi‐Lin Liu, Song Shen, Jun Wang   +9 more
wiley   +1 more source

Gender Differences in Survival in Idiopathic Pulmonary Fibrosis and Following Lung Transplant [PDF]

, 2008
Idiopathic Pulmonary Fibrosis (IPF) is a chronic and progressive form of interstitial lung disease characterized by inflammation and abnormal tissue repair ultimately leading to decreased pulmonary function and death.
Creel, Michael Eric
core  

Recent advances in understanding idiopathic pulmonary fibrosis [PDF]

, 2016
Despite major research efforts leading to the recent approval of pirfenidone and nintedanib, the dismal prognosis of idiopathic pulmonary fibrosis (IPF) remains unchanged.
Daccord, C, Maher, TM
core   +3 more sources

Leucine‐Rich Repeat‐Containing G Protein‐Coupled Receptor 6 Ameliorates Pressure Overload‐Induced Cardiac Hypertrophy by Regulating Cardiomyocyte Metabolic Reprogramming

Advanced Science, EarlyView.
LGR6 overexpression ameliorates cardiac hypertrophy by regulating metabolic reprogramming through USP4‐PPARα pathway. Abstract Metabolic reprogramming is a pivotal mechanism in the pathogenesis of pathological cardiac hypertrophy. Leucine‐rich repeat‐containing G protein‐coupled receptor 6 (Lgr6) has emerged as a significant player in cardiovascular ...
Mengmeng Zhao, Jianfang Liu, Shanshan Peng, Zihui Zheng, Siqi Liu, Jun Wan, Yao Xu, Menglong Wang   +7 more
wiley   +1 more source

Entropy Production and the Pressure-Volume Curve of the Lung [PDF]

, 2015
We investigate analytically the production of entropy during a breathing cycle in healthy and diseased lungs. First, we calculate entropy production in healthy lungs by applying the laws of thermodynamics to the well-known transpulmonary pressure-volume ($P-V$) curves of the lung under the assumption that lung tissue behaves as an entropy spring-like ...
arxiv   +1 more source

MRI of the lung (3/3)-current applications and future perspectives [PDF]

, 2011
BACKGROUND: MRI of the lung is recommended in a number of clinical indications. Having a non-radiation alternative is particularly attractive in children and young subjects, or pregnant women.
A Hebestreit, A Kluge, A Kluge, A Kluge, AA Bankier, AC Henderson, AS Brody, BJ Pichler, BJ Pichler, C Fink, C Hintze, C Hintze, C Rieger, CA Yi, CA Yi, CP Heussel, DM Mannino, F Molinari, F Risse, F Santamaria, G Antoch, G Antoch, G Bauman, G Bauman, G Lutterbey, G Lutterbey, G Sergiacomi, H Hatabu, H Zaidi, HF Wehrl, HK Song, HK Song, IL Theissen, J Biederer, J Biederer, J Biederer, J Biederer, J Biederer, J Biederer, J Biederer, J Ley-Zaporozhan, J Ley-Zaporozhan, JC Hogg, K Cederlund, K Sandek, K Suga, K Suga, LP Qi, M Bhalla, M Decramer, M Eichinger, M Gaeta, M Oudkerk, M Puderbach, M Puderbach, M Puderbach, M Puderbach, M Stern, M Wagner, MD Cohen, ND Abolmaali, NJ Morrison, NL Müller, O Ratib, PA Jong de, PA Jong de, PD Stein, PD Stein, R Eibel, R Failo, RE Jacob, RG McFadden, RJ Theilmann, RL Gibson, S Akata, S Montella, S Pauls, SK Alford, T Amundsen, T Iwasawa, T Iwasawa, T Iwasawa, T Mori, T Rupprecht, TA Kuder, TH Helbich, US Euler, V Peltola, W Hirsch, W Lin, Y Berthezène, Y Ohba, Y Ohno, Y Ohno, Y Ohno, Y Ohno, Y Shao   +96 more
core   +1 more source

Nephronectin (NPNT) is a Crucial Determinant of Idiopathic Pulmonary Fibrosis: Modulating Cellular Senescence via the ITGA3/YAP1 Signaling Axis

Advanced Science, EarlyView.
Through a comprehensive multi‐omics analysis, this study identifies a marked reduction in Nephronectin (NPNT) expression within fibrotic lung tissue. This reduction impairs the binding capability to the ITGA3 receptor, consequently causing YAP1 to persist in the cytoplasm, where it undergoes degradation.
Jiayu Guo, Yan Wang, Qiudi Liu, Zhaoyang Luo, Xiaomu Tian, Yuquan Wang, Yang Liu, Zhiwei Ning, Yingying Guo, Huiying Gao, Xinyue Wang, Jinglong Feng, Mengmeng Liu, Dina Saifullina, Yixin Zhang, Tengfei Pan, Yu Bian, Tao Ban, Tianyu Li, Yunyan Gu, Haihai Liang   +20 more
wiley   +1 more source

Diagnostic test interpretation and referral delay in patients with interstitial lung disease. [PDF]

, 2019
BACKGROUND:Diagnostic delays are common in patients with interstitial lung disease (ILD). A substantial percentage of patients experience a diagnostic delay in the primary care setting, but the factors underpinning this observation remain unclear.
Adegunsoye, Ayodeji, Boctor, Noelle, Chung, Jonathan H, DiGeronimo, Ryan, Kadoch, Michael, Lafond, Elyse, Oldham, Justin M, Pan, Isabella, Pritchard, David, Pugashetti, Janelle Vu, Sarma, Nandini, Strek, Mary   +11 more
core   +1 more source

Bleomycin increases neutrophil adhesion to human vascular endothelial cells independently of upregulation of ICAM-1 and E-selectin [PDF]

, 2016
© 2016 Taylor & Francis. Aim of the Study: Bleomycin-induced lung disease is a serious complication of therapy characterized by alveolar injury, cytokine release, inflammatory cell recruitment, and eventually pulmonary fibrosis.
Crooks, Michael G., Greenman, John, Hart, Simon P., Sadofsky, Laura R., Williamson, James D.   +4 more
core   +1 more source