Results 111 to 120 of about 174,250 (219)
Clinical Pharmacology in Drug Development, Volume 12, Issue 1, Page 30-37, January 2023., 2023 Abstract The bioequivalence of a generic fudosteine tablet vs a brand‐named fudosteine tablet under fasting and fed conditions was evaluated in this study. This randomized, open‐label, single‐dose, 4‐way replicate, crossover, bioequivalence study included 64 healthy Chinese subjects (fasting cohort, n = 32; fed cohort, n = 32) who were assigned to ...
Mingxue Zhu +6 more
wiley +1 more source
Mucociliary Transport in Healthy and Diseased Environments [PDF]
arXiv, 2016 Mucociliary clearance in the lung is the primary defense mechanism that protects the airways from inhaled toxicants and infectious agents. The system consists of a viscoelastic mucus layer driven by motile cilia in a periciliary layer underneath the mucus layer.
arxiv
Cell Membrane‐Coated Lipid Nanoparticles for Drug Delivery
Aggregate, EarlyView.This review highlights recent progress in cell membrane‐coated lipid nanoparticles (CMC‐LNPs), focusing on their design, preparation methods, functional integration, and biomedical applications. It discusses various types of LNPs and coating strategies, characterization techniques, therapeutic functions, and applications.
Moataz B. Zewail +5 more
wiley +1 more source
Joint Models for Time-to-Event Data and Longitudinal Biomarkers of High Dimension [PDF]
arXiv, 2016 Joint models for longitudinal biomarkers and time-to-event data are widely used in longitudinal studies. Many joint modeling approaches have been proposed to deal with different types of longitudinal biomarkers and survival outcomes. However, most existing joint modeling methods cannot deal with a large number of longitudinal biomarkers simultaneously,
arxiv
Carcinoma of the lung and diffuse interstitial pulmonary fibrosis [PDF]
, 1968 B. Fox, R. A. Risdon
openalex +1 more source
Applied Artificial Intelligence in Materials Science and Material Design
Advanced Intelligent Systems, EarlyView.AI‐driven methods are transforming materials science by accelerating material discovery, design, and analysis, leveraging large datasets to enhance predictive modeling and streamline experimental techniques. This review highlights advancements in AI applications across spectroscopy, microscopy, and molecular design, enabling efficient material ...
Emigdio Chávez‐Angel +7 more
wiley +1 more source
CIResDiff: A Clinically-Informed Residual Diffusion Model for Predicting Idiopathic Pulmonary Fibrosis Progression [PDF]
arXivThe progression of Idiopathic Pulmonary Fibrosis (IPF) significantly correlates with higher patient mortality rates. Early detection of IPF progression is critical for initiating timely treatment, which can effectively slow down the advancement of the disease. However, the current clinical criteria define disease progression requiring two CT scans with
arxiv
Medium‐chain Acyl‐COA dehydrogenase deficiency: Pathogenesis, diagnosis, and treatment
Endocrinology, Diabetes &Metabolism, Volume 6, Issue 1, January 2023., 2023 MCADD is a commonly inherited metabolic disease with serious implications for health outcomes, particularly in children, that may be successfully managed with proper intervention. In this review, we discuss the genetics, pathogenesis, clinical presentation, diagnosis, and treatments for Medium‐Chain Acyl‐CoA Dehydrogenase Deficiency (MCADD ...
Emily Mason +2 more
wiley +1 more source
Targeted Therapies in Myelofibrosis: Present Landscape, Ongoing Studies, and Future Perspectives
American Journal of Hematology, EarlyView.ABSTRACT Myelofibrosis (MF) is a myeloproliferative neoplasm that is accompanied by driver JAK2, CALR, or MPL mutations in more than 90% of cases, leading to constitutive activation of the JAK–STAT pathway. MF is a multifaceted disease characterized by trilineage myeloid proliferation with prominent megakaryocyte atypia and bone marrow fibrosis, as ...
Giuseppe G. Loscocco, Paola Guglielmelli
wiley +1 more source