Results 111 to 120 of about 1,854,852 (401)

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source

Infant Pulmonary Function Testing in Pediatric Diffuse Parenchymal Lung Disease

CHEST Pulmonary
Topic Importance: Diffuse parenchymal lung disease (DPLD) in pediatrics, also known as children’s interstitial lung disease, comprises a diverse group of rare and chronic respiratory disorders affecting the pediatric population. Diagnosing and monitoring
Avigdor Hevroni, MD, Alex Gileles-Hillel, MD, Malena Cohen-Cymberknoh, MD, Joel Reiter, MD, David Shoseyov, MD, Reuven Tsabari, MD, Chaim Springer, MD, Laurice S. Boursheh, MD, Oded Breuer, MD   +8 more
doaj   +1 more source

The 6 minute walk in idiopathic pulmonary fibrosis: longitudinal changes and minimum important difference [PDF]

, 2010
The response characteristics of the 6 minute walk test (6MWT) in studies of idiopathic pulmonary fibrosis (IPF) are only poorly understood, and the change in walk distance that constitutes the minimum important difference (MID) over time is ...
Behr, Jürgen, Brown, Kevin K., du Bois, Roland M., King, Talmadge E., Raghu, Ganesh, Swigris, Jeffrey J., Wamboldt, Frederick S.   +6 more
core   +1 more source

Emerging cellular and molecular determinants of idiopathic pulmonary fibrosis

Cellular and Molecular Life Sciences, 2020
Idiopathic pulmonary fibrosis (IPF), the most common form of idiopathic interstitial pneumonia, is a progressive, irreversible, and typically lethal disease characterized by an abnormal fibrotic response involving vast areas of the lungs.
T. Phan, P. Paliogiannis, Gheyath K Nasrallah, Roberta Giordo, A. Eid, A. Fois, A. Zinellu, A. Mangoni, G. Pintus   +8 more
semanticscholar   +1 more source

EPS6.03 Pulmonary pathogen prevalence 12 months after elexacaftor/tezacaftor/ivacaftor introduction: results from the Danish National Cystic Fibrosis Cohort [PDF]

, 2023
M. Jeppesen, S. Jensen-Fangel, Camilla Bjørn Jensen, Terese L. Katzenstein, M. Wang, M. Frahm Olesen, T. Pressler, Marianne Skov, Hanne Vebert Olesen, Tavs Qvist   +9 more
openalex   +1 more source

A Vascular Microphysiological Model of Lung Fibrosis Reveals That Myofibroblasts and IPF Patient‐Derived Fibroblasts Impair Angiogenesis and Vasculogenesis

Advanced Functional Materials, EarlyView.
A microphysiological lung fibrosis model recapitulates myofibroblast–vascular interactions. Induced myofibroblasts and patient‐derived IPF fibroblasts impair angiogenesis and increase vascular permeability via TGF‐β1–driven signaling. Pharmacological interventions with SB 431542 and VEGF supplementation restore vascular morphology and barrier function.
Elena Cambria, Adriana Blazeski, Eunkyung Clare Ko, Tran Thai, Shania Dantes, David A. Barbie, Sarah E. Shelton, Roger D. Kamm   +7 more
wiley   +1 more source

Patterns of CT lung injury and toxicity after stereotactic radiotherapy delivered with helical tomotherapy in early stage medically inoperable NSCLC [PDF]

, 2015
To evaluate toxicity and patterns of radiologic lung injury on CT images after hypofractionated image-guided stereotactic body radiotherapy (SBRT) delivered with helical tomotherapy (HT) in medically early stage inoperable non-small-cell lung cancer ...
Agolli, Linda, Arcangeli, S, Bracci, S, Dognini, Jessica, Donato, Vittorio, Lopergolo, M. G, Migliorino, M. R, Monaco, Alessia, Portalone, L, Pressello, M. C   +9 more
core   +1 more source

Scutellarin ameliorates pulmonary fibrosis through inhibiting NF-κB/NLRP3-mediated epithelial–mesenchymal transition and inflammation

Cell Death and Disease, 2020
Idiopathic pulmonary fibrosis (IPF) is featured with inflammation and extensive lung remodeling caused by overloaded deposition of extracellular matrix. Scutellarin is the major effective ingredient of breviscapine and its anti-inflammation efficacy has ...
Ling Peng, L. Wen, Qingfeng Shi, Feng Gao, Bin Huang, J. Meng, Cheng-ping Hu, Changming Wang   +7 more
semanticscholar   +1 more source

Longitudinal Micro-Computed Tomography Detects Onset and Progression of Pulmonary Fibrosis in ConditionalNedd4-2Deficient Mice [PDF]

, 2023
Dominik Leitz, Philip Konietzke, Willi L. Wagner, Mara Mertiny, Claudia Benke, Thomas Schneider, Wolfram Stiller, Hans‐Ulrich Kauczor, Marcus Mall, Julia Duerr, Mark O. Wielpütz   +10 more
openalex   +1 more source

Nano‐ and Micro‐Sized Solid Materials Used as Antiviral Agents

Advanced Functional Materials, EarlyView.
Due to the rise of viral infections in humans and possible viral outbreaks, the use of nano‐ or micro‐sized materials as antiviral agents is rapidly increasing. This review explores their antiviral properties against RNA and DNA viruses, either as a prevention or a treatment tool, by delving into their mechanisms of action and how to properly assess ...
Orfeas‐Evangelos Plastiras, Imelda Raczkiewicz, Peggy Bouquet, Jean‐Philippe Dacquin, Jeremy Dhainaut, Anne Goffard, Christophe Volkringer   +6 more
wiley   +1 more source