Results 111 to 120 of about 412,177 (358)

The EDD (exercise, DLco, dyspnea) index in diffuse systemic sclerosis with pulmonary fibrosis [PDF]

Introduction: Pulmonary fibrosis secondary to systemic sclerosis (SSc) is the major cause of morbidity and mortality in these patients. The aim of this study was to determine the correlation of important lung function parameters with chest high ...
اخلاقی, سعید, شریعتی, ژاله, عطاران, داود, قبادی مراللو, حسن, محمدزاده لاری, شهرزاد, نظری, پویا   +5 more
core  

Endothelial BMP6 Drives Hemodynamic‐Dependent VSMCs Calcification in Carotid Atherosclerosis

Advanced Science, EarlyView.
The study demonstrates that endothelial cell (EC)‐derived BMP6 promotes the osteogenic differentiation of vascular smooth muscle cells (VSMCs) through cell‐cell interactions. Additionally, the researchers preliminarily explore the driving effect of hemodynamic factors on BMP6‐induced calcification and reveal the regulatory role of KLF4 on BMP6.
Shen Li, Shuang Cao, Peipei Li, Feng Zhang, Gangfeng Ren, Xin Wang, Jiawei Zhao, Chen Liu, Yuan Gao, Jie Xu, Yongjun Wang, Zongping Xia, Yuming Xu   +12 more
wiley   +1 more source

Dysphagia Due to Unilateral Pulmonary Fibrosis [PDF]

, 1936
Alex. T. Doig
openalex   +1 more source

Idiopathic pulmonary fibrosis: evaluation of progression and prognosis after the ATS/ERS/JRS/ALAT statement 2011 [PDF]

, 2012
Objectives The prediction of usual interstitial pneumonia (UIP) progression and prognosis by the a application of HRCT criteria pattern recommended by ATS/ERS/JALAT guidelines 2011 Materials and methods Two radiologists after assessing the baseline HRCT ...
ROMEI, CHIARA
core  

Mesencephalic Astrocyte‐Derived Neurotrophic Factor Binds BAX to Preserve Mitochondrial Homeostasis and Energy Metabolism for Relieving Myocardial Hypertrophy

Advanced Science, EarlyView.
MANF in cardiomyocytes interacts with BAX to impede BAX mitochondrial translocation and cytochrome c release, further stabilizing mitochondrial structure and energy supply to relieve myocardial apoptosis and hypertrophy, which indicates MANF as a novel cardioprotective factor to have a promising clinical application for myocardial hypertrophy ...
Dong Wang, Xinru Zhang, Baolong Wang, Haipeng Li, Dongshuo Xu, Yun Yang, Jialu Zhang, Wenbing Wang, Ren Zhang, Xinyu Wang, Yunfeng Cai, Shiyu Cao, Chao Hou, Changhui Wang   +13 more
wiley   +1 more source

CAMKK2 restored mitochondrial dynamics homeostasis to alleviate pulmonary fibrosis via AMPK/PGC-1α signaling pathway in lung fibroblasts

Molecular Medicine
Background Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease characterized by aberrant fibroblast activation and extracellular matrix deposition. Emerging evidence implicates mitochondrial dysfunction in IPF pathogenesis.
Yanlin Zhou, Yuqi Wang, Mengyuan Wang, Bin Li, Kai Xu, Xiaoyue Pan, Zhongzheng Li, Qiwen Wang, Wanyu He, Jiaojiao Pang, Yingchun Guo, Yuqing Zhang, Koji Sakamoto, Juntang Yang, Lan Wang, Guoying Yu   +15 more
doaj   +1 more source

Triiodothyronine acts on DAO to regulate pulmonary fibrosis progression by facilitating cell senescence through the p53/p21 signaling pathway

Frontiers in Pharmacology
BackgroundIdiopathic pulmonary fibrosis (IPF) is the result of multiple cycles of epithelial cell injury and fibroblast activation; currently, there is no clear etiology. Increasing evidence suggests that protein metabolism and amino acids play a crucial
Xiaoshu Guo, Xiaoshu Guo, Kai Xu, Lan Wang, Linke Ding, Wenwen Li, Xinsheng Zhang, Weiming Zhao, Ningdan Wang, Gaiping Wang, Wenyu Zhao, Ivan Rosas, Guoying Yu   +12 more
doaj   +1 more source

PULMONARY FIBROSIS: AN INVESTIGATION INTO THE ORIGIN AND COURSE [PDF]

, 1928
C. de W. Kitcat, T. Holmes Sellors
openalex   +1 more source

Histone Lactylation‐Driven Upregulation of VRK1 Expression Promotes Stemness and Proliferation of Glioma Stem Cells

Advanced Science, EarlyView.
Glioblastoma (GBM) is the most aggressive primary brain tumor, with glioma stem cells (GSCs) driving treatment resistance. This study reveals that lactate promotes histone lactylation (H3K18la) at the VRK1 promoter, regulating GSC stemness and proliferation via the H3K18la/VRK1/YBX1/SOX2 pathway. The VRK1‐targeted nanoliposome A/TMZ‐siVRK1 demonstrates
Jinna Li, Chenyue Tang, Xuefeng Zhang, Rui Xing, Qing Guo   +4 more
wiley   +1 more source

Hibiscus manihot L. flower extract induces anticancer activity through modulation of apoptosis and autophagy in A549 cells

Scientific Reports
Lung cancer is a major public health issue and heavy burden in China and worldwide due to its high incidence and mortality without effective treatment. It’s imperative to develop new treatments to overcome drug resistance.
Minglu Xu, Mengxia Zhao, Miaomiao Zhu, Hongmei Yuan, Zhongzheng Li, Peishuo Yan, Chi Ma, Huabin Zhao, Shenghui Wang, Ruyan Wan, Lan Wang, Guoying Yu   +11 more
doaj   +1 more source