The role of the cytoskeleton in fibrotic diseases
Frontiers in Cell and Developmental BiologyFibrosis is the process whereby cells at a damaged site are transformed into fibrotic tissue, comprising fibroblasts and an extracellular matrix rich in collagen and fibronectin, following damage to organs or tissues that exceeds their repair capacity ...
Caoyuan Niu +5 more
doaj +1 more source
The effect of elexacaftor/tezacaftor/ivacaftor on non-pulmonary symptoms in adults with cystic fibrosis [PDF]
, 2023 Sarah Allgood +5 more
openalex +1 more source
Advanced Science, EarlyView.Lipid droplets (LDs) protect the heart against lipotoxicity in cardiac ischemia/reperfusion (I/R) injury; however, they are insufficient to prevent cardiomyocyte death. Seipin plays a central role in the insufficient formation of LDs, subsequent lipotoxicity, and myocardial injury during cardiac I/R injury.
Changyun Liu +13 more
wiley +1 more source
Diagnostic test interpretation and referral delay in patients with interstitial lung disease. [PDF]
, 2019 BACKGROUND:Diagnostic delays are common in patients with interstitial lung disease (ILD). A substantial percentage of patients experience a diagnostic delay in the primary care setting, but the factors underpinning this observation remain unclear.
Adegunsoye, Ayodeji +11 more
core +1 more source
LONG TERM EXPERIENCE WITH BOSENTAN IN PATIENTS WITH PULMONARY ARTERIAL HYPERTENSION (PAH) ASSOCIATED WITH ADVANCED IDIOPATHIC PULMONARY FIBROSIS (IPF) AND INTERSTITIAL LUNG DISEASE (ILD): A RETROSPECTIVE CASE SERIES [PDF]
, 2005 Ganesh Raghu +4 more
openalex +1 more source
Advanced Science, EarlyView.Scars exhibit vascular abnormal alterations, including upregulated NRP1 expression in endothelial cells, increased vascular density and branching, compromised vessel wall integrity, and incomplete pericyte coverage. Therapeutic targeting of NRP1 through hydrogel spray delivery offers a promising approach to normalize aberrant vasculature and prevent ...
Yu Wang +11 more
wiley +1 more source
The EDD (exercise, DLco, dyspnea) index in diffuse systemic sclerosis with pulmonary fibrosis [PDF]
Introduction: Pulmonary fibrosis secondary to systemic sclerosis (SSc) is the major cause of morbidity and mortality in these patients. The aim of this study was to determine the correlation of important lung function parameters with chest high ...
اخلاقی, سعید +5 more
core
P9 Cough Is Prevalent In Higher Proportion Of Older Patients With Both Idiopathic Pulmonary Fibrosis And Non-specific Interstitial Lung Disease [PDF]
, 2014 G. Saini +7 more
openalex +1 more source
Mesenchymal Stem Cell-Derived Extracellular Vesicles as Idiopathic Pulmonary Fibrosis Microenvironment Targeted Delivery [PDF]
, 2022 Lu Sang +5 more
openalex +1 more source
Advanced Science, EarlyView.Normal bladders exhibit quiescent fibroblasts/macrophages, whereas neurogenic bladders show acute‐phase Itga8⁺ fibroblast expansion driven by Trem2⁺ macrophage‐secreted Fn1, which activates FAK/RhoA/ROCK signaling, promotes cytoskeletal remodeling, and upregulates pro‐fibrotic genes.
Jiaxin Wang +9 more
wiley +1 more source