Results 31 to 40 of about 1,854,852 (401)

Efficacy of antifibrotic drugs, nintedanib and pirfenidone, in treatment of progressive pulmonary fibrosis in both idiopathic pulmonary fibrosis (IPF) and non-IPF: a systematic review and meta-analysis

BMC Pulmonary Medicine, 2021
Background Research questions To compare the efficacy of nintedanib and pirfenidone in the treatment of progressive pulmonary fibrosis; and to compare the efficacy of anti-fibrotic therapy (grouping nintedanib and pirfenidone together) in patients with ...
J. Finnerty, A. Ponnuswamy, Prosjenjit Dutta, Ammar Abdelaziz, H. Kamil   +4 more
semanticscholar   +1 more source

Tracking dyspnea up to supplemental oxygen prescription among patients with pulmonary fibrosis

BMC Pulmonary Medicine, 2017
Background Dyspnea is the hallmark symptom of pulmonary fibrosis. Supplemental oxygen (O2) is prescribed to many patients with pulmonary fibrosis in hopes of alleviating dyspnea and improving physical functioning.
Amy L. Olson, Bridget Graney, Susan Baird, Tara Churney, Kaitlin Fier, Marjorie Korn, Mark McCormick, David Sprunger, Thomas Vierzba, Frederick S. Wamboldt, Jeffrey J. Swigris   +10 more
doaj   +1 more source

Tuftelin1 drives experimental pulmonary fibrosis progression by facilitating stress fiber assembly

Respiratory Research, 2023
Background Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease (ILD) with unknown etiology, characterized by sustained damage repair of epithelial cells and abnormal activation of fibroblasts, the underlying mechanism of the ...
Caoyuan Niu, Kai Xu, Yanan Hu, Yanling Jia, Yuexia Yang, Xiaoyue Pan, Ruyan Wan, Hui Lian, Qiwen Wang, Juntang Yang, Yajun Li, Ivan Rosas, Lan Wang, Guoying Yu   +13 more
doaj   +1 more source

Lung Cancer in Pulmonary Fibrosis: Tales of Epithelial Cell Plasticity [PDF]

, 2011
Lung epithelial cells exhibit a high degree of plasticity. Alterations to lung epithelial cell function are critically involved in several chronic lung diseases such as pulmonary fibrosis.
Adamson IY, Artinian V, Aubry MC, Bai JW, Baumgartner KB, Berschneider B, Brody AR, Chen PP, Chilosi M, Chilosi M, Coalson JJ, Corrin B, Dasari V, Dissanayake SK, Dobbs LG, Flozak AS, Fukuda Y, Ha HY, Haddad R, Herzog EL, Hironaka M, Hu J, Huang CL, Hubbard R, Huber MA, Jayachandran A, Kasai H, Kasper M, Kato N, Kawasaki H, Kawasaki H, Kim J, Kim K, Kim KK, Kuwano K, Königshoff M, Königshoff M, Königshoff M, Lee JM, Liu L, Maher TM, Margalit O, Mason RJ, Matthay MA, Mazieres J, Melanie Königshoff, Moon RT, Nagai A, Pan LH, Park J, Pennison M, Plataki M, Qunn L, Radisky DC, Rosas IO, Sato M, Selman M, Selman M, Soon LL, Sternlicht MD, Thannickal VJ, Thiery JP, Uematsu K, Willis BC, Willis BC, Willis BC, Zavadil J   +66 more
core   +1 more source

Single-cell RNA-seq reveals ectopic and aberrant lung-resident cell populations in idiopathic pulmonary fibrosis

Science Advances, 2020
Human lung single-cell atlas reveals the complexity and diversity of aberrant cellular populations in pulmonary fibrosis. We provide a single-cell atlas of idiopathic pulmonary fibrosis (IPF), a fatal interstitial lung disease, by profiling 312,928 cells
T. Adams, J. Schupp, S. Poli, Ehab A. Ayaub, N. Neumark, F. Ahangari, S. Chu, B. Raby, G. DeIuliis, Michael Januszyk, Qiaonan Duan, H. Arnett, Asim Siddiqui, G. Washko, R. Homer, Xiting Yan, I. Rosas, N. Kaminski   +17 more
semanticscholar   +1 more source

Coagulation and anticoagulation in idiopathic pulmonary fibrosis [PDF]

, 2015
Idiopathic pulmonary fibrosis (IPF) is an incurable, progressive interstitial lung disease with a prognosis that is worse than that of many cancers. Epidemiological studies have demonstrated a link between IPF and thrombotic vascular events.
Crooks, Michael G., Hart, Simon P.
core   +3 more sources

Single-cell RNA sequencing reveals profibrotic roles of distinct epithelial and mesenchymal lineages in pulmonary fibrosis

Science Advances, 2020
Single-cell RNA sequencing provides new insights into pathologic epithelial and mesenchymal remodeling in the human lung. Pulmonary fibrosis (PF) is a form of chronic lung disease characterized by pathologic epithelial remodeling and accumulation of ...
A. Habermann, A. Gutierrez, L. T. Bui, Stephanie L. Yahn, N. Winters, C. Calvi, L. Peter, M. Chung, Chase J. Taylor, C. Jetter, Latha Raju, J. Roberson, G. Ding, L. Wood, J. Sucre, B. Richmond, A. Serezani, Wyatt J. McDonnell, Simon Mallal, M. Bacchetta, J. Loyd, C. Shaver, L. Ware, R. Bremner, R. Walia, T. Blackwell, N. Banovich, JA Kropski   +27 more
semanticscholar   +1 more source

Role of interleukins in the pathogenesis of pulmonary fibrosis

Cell Death Discovery, 2021
Interleukins, a group of cytokines participating in inflammation and immune response, are proved to be involved in the formation and development of pulmonary fibrosis.
Y. She, Q. Yu, X. Tang
semanticscholar   +1 more source

Alveolar cells under mechanical stressed niche: critical contributors to pulmonary fibrosis

Molecular Medicine, 2020
Pulmonary fibrosis arises from the repeated epithelial mild injuries and insufficient repair lead to over activation of fibroblasts and excessive deposition of extracellular matrix, which result in a mechanical stretched niche.
Juntang Yang, Xin Pan, Lan Wang, Guoying Yu   +3 more
doaj   +1 more source

Amelioration of bleomycin-induced lung fibrosis in hamsters by dietary supplementation with taurine and niacin: biochemical mechanisms. [PDF]

, 1994
Interstitial pulmonary fibrosis induced by intratracheal instillation of bleomycin (BL) involves an excess production of reactive oxygen species, unavailability of adequate levels of NAD and ATP to repair the injured pulmonary epithelium, and an ...
Chandler DB, Chien KR, Christner P, Clark JG, Counts DF, Crouch E, D M Hyde, Fukae M, Garnick MB, Giri SN, Giri SN, Karlinski JB, Kelley J, Koob TJ, Lowry OH, Marom Z, McQuaid A, Misra HP, Moss DW, Nakashima JM, Nakashima T, Phan SH, Q Wang, R B Rucker, R Blaisdell, Reiser KM, Riley DJ, S N Giri, Scherle WF, Snider GL, Thrall RS, Trush MA, Wang Q, Witschi HP, Zuckerman JE   +34 more
core   +2 more sources