Alveolar cells under mechanical stressed niche: critical contributors to pulmonary fibrosis
Molecular Medicine, 2020 Pulmonary fibrosis arises from the repeated epithelial mild injuries and insufficient repair lead to over activation of fibroblasts and excessive deposition of extracellular matrix, which result in a mechanical stretched niche.
Juntang Yang +3 more
doaj +1 more source
Senescence of Alveolar Type 2 Cells Drives Progressive Pulmonary Fibrosis.
American Journal of Respiratory and Critical Care Medicine, 2020 RATIONALE Idiopathic pulmonary fibrosis (IPF) is an insidious and fatal interstitial lung disease associated with declining pulmonary function. Accelerated aging, loss of epithelial progenitor cell function and/or numbers and cellular senescence are ...
C. Yao +14 more
semanticscholar +1 more source
IL-33 promotes ST2-dependent lung fibrosis by the induction of alternatively activated macrophages and innate lymphoid cells in mice [PDF]
, 2014 Background<p></p> The initiation and regulation of pulmonary fibrosis are not well understood. IL-33, an important cytokine for respiratory diseases, is overexpressed in the lungs of patients with idiopathic pulmonary fibrosis.<p>< ...
Besnard, Anne-Gaëlle +10 more
core +3 more sources
Inhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosis
Nature Communications, 2020 Idiopathic pulmonary fibrosis (IPF) is a fatal and incurable form of interstitial lung disease in which persistent injury results in scar tissue formation.
P. Dinh +24 more
semanticscholar +1 more source
Amelioration of bleomycin-induced lung fibrosis in hamsters by dietary supplementation with taurine and niacin: biochemical mechanisms. [PDF]
, 1994 Interstitial pulmonary fibrosis induced by intratracheal instillation of bleomycin (BL) involves an excess production of reactive oxygen species, unavailability of adequate levels of NAD and ATP to repair the injured pulmonary epithelium, and an ...
Chandler DB +34 more
core +2 more sources
Virus infection induced pulmonary fibrosis
Journal of Translational Medicine, 2021 Pulmonary fibrosis is the end stage of a broad range of heterogeneous interstitial lung diseases and more than 200 factors contribute to it. In recent years, the relationship between virus infection and pulmonary fibrosis is getting more and more ...
Wei Huang, X. Tang
semanticscholar +1 more source
Using bacterial biomarkers to identify early indicators of cystic fibrosis pulmonary exacerbation onset [PDF]
, 2011 Acute periods of pulmonary exacerbation are the single most important cause of morbidity in cystic fibrosis patients, and may be associated with a loss of lung function.
Bruce, Kenneth D +6 more
core +1 more source
Tackling MARCKS-PIP3 circuit attenuates fibroblast activation and fibrosis progression. [PDF]
, 2019 Targeting activated fibroblasts, including myofibroblast differentiation, has emerged as a key therapeutic strategy in patients with idiopathic pulmonary fibrosis (IPF).
Chen, Ching-Hsien +7 more
core +2 more sources
Protective role of cortistatin in pulmonary inflammation and fibrosis [PDF]
, 2021 Fundacao de Amparo a Pesquisa do Estado de Sao Paulo, Grant/Award Number: 12/21767-5; Ministerio de Ciencia e Innovacion, Grant/Award Number: SAF2015-67787-RBackground and Purpose: Acute lung injury (ALI), acute respiratory distress syndrome (ARDS) and ...
Barriga, Margarita +8 more
core +1 more source
International Journal of Molecular Sciences, 2021 Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal interstitial lung disease. During the past decade, novel pathogenic mechanisms of IPF have been elucidated that have shifted the concept of IPF from an inflammatory-driven to an epithelial ...
N. Inui, Satoshi Sakai, M. Kitagawa
semanticscholar +1 more source