Results 31 to 40 of about 1,677,383 (218)

Molecular Pathogenesis of Pulmonary Fibrosis, with Focus on Pathways Related to TGF-β and the Ubiquitin-Proteasome Pathway

International Journal of Molecular Sciences, 2021
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal interstitial lung disease. During the past decade, novel pathogenic mechanisms of IPF have been elucidated that have shifted the concept of IPF from an inflammatory-driven to an epithelial ...
N. Inui, Satoshi Sakai, M. Kitagawa
semanticscholar   +1 more source

Informal caregivers experience of supplemental oxygen in pulmonary fibrosis

Health and Quality of Life Outcomes, 2017
Background Patients prescribed supplemental oxygen (O2) therapy face challenges as they adjust to being constantly “tethered” to an oxygen delivery device.
Bridget A. Graney, Frederick S. Wamboldt, Susan Baird, Tara Churney, Kaitlin Fier, Marjorie Korn, Mark McCormick, Thomas Vierzba, Jeffrey J. Swigris   +8 more
doaj   +1 more source

Efficacy of antifibrotic drugs, nintedanib and pirfenidone, in treatment of progressive pulmonary fibrosis in both idiopathic pulmonary fibrosis (IPF) and non-IPF: a systematic review and meta-analysis

BMC Pulmonary Medicine, 2021
Background Research questions To compare the efficacy of nintedanib and pirfenidone in the treatment of progressive pulmonary fibrosis; and to compare the efficacy of anti-fibrotic therapy (grouping nintedanib and pirfenidone together) in patients with ...
J. Finnerty, A. Ponnuswamy, Prosjenjit Dutta, Ammar Abdelaziz, H. Kamil   +4 more
semanticscholar   +1 more source

Pulmonary Fibrosis in COVID-19 Survivors: Predictive Factors and Risk Reduction Strategies

Pulmonary Medicine, 2020
Although pulmonary fibrosis can occur in the absence of a clear-cut inciting agent, and without a clinically clear initial acute inflammatory phase, it is more commonly associated with severe lung injury.
Ademola S. Ojo, S. Balogun, Oyeronke T Williams, O. Ojo   +3 more
semanticscholar   +1 more source

Alveolar Epithelial Type II Cells as Drivers of Lung Fibrosis in Idiopathic Pulmonary Fibrosis

International Journal of Molecular Sciences, 2020
Alveolar epithelial type II cells (AT2) are a heterogeneous population that have critical secretory and regenerative roles in the alveolus to maintain lung homeostasis.
T. Parimon, C. Yao, B. Stripp, P. Noble, Peter Chen   +4 more
semanticscholar   +1 more source

Idiopathic pulmonary fibrosis beyond the lung: understanding disease mechanisms to improve diagnosis and management

Respiratory Research, 2021
Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive disorder with an estimated median survival time of 3–5 years after diagnosis. This condition occurs primarily in elderly subjects, and epidemiological studies suggest that the main risk ...
F. Luppi, M. Kalluri, P. Faverio, M. Kreuter, G. Ferrara   +4 more
semanticscholar   +1 more source

Scutellarin ameliorates pulmonary fibrosis through inhibiting NF-κB/NLRP3-mediated epithelial–mesenchymal transition and inflammation

Cell Death and Disease, 2020
Idiopathic pulmonary fibrosis (IPF) is featured with inflammation and extensive lung remodeling caused by overloaded deposition of extracellular matrix. Scutellarin is the major effective ingredient of breviscapine and its anti-inflammation efficacy has ...
Ling Peng, L. Wen, Qingfeng Shi, Feng Gao, Bin Huang, J. Meng, Cheng-ping Hu, Changming Wang   +7 more
semanticscholar   +1 more source

Use of ivacaftor in late diagnosed cystic fibrosis monozygotic twins heterozygous for F508del and R117H-7T – a case report

BMC Pulmonary Medicine, 2019
Background CFTR modulator therapy with ivacaftor is a treatment option for Cystic Fibrosis (CF) patients with at least one copy of a R117H-7T mutation in the CFTR gene.
Matthias Welsner, Svenja Straßburg, Christian Taube, Sivagurunathan Sutharsan   +3 more
doaj   +1 more source

Cough suppression and HRQoL in adult people with cystic fibrosis: an unexplored correlation

Health and Quality of Life Outcomes, 2022
Background Cough suppression assessed by embarrassment about coughing has been shown in adolescents with cystic fibrosis (CF) and negatively affects health-related quality of life (HRQoL) and clinical indicators of disease severity in adolescent females.
Ute Niehammer, Mathis Steindor, Svenja Straßburg, Sivagurunathan Sutharsan, Christian Taube, Matthias Welsner, Raphael Hirtz, Florian Stehling   +7 more
doaj   +1 more source

Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary Fibrosis

American Journal of Respiratory and Critical Care Medicine, 2019
Rationale: The contributions of diverse cell populations in the human lung to pulmonary fibrosis pathogenesis are poorly understood. Single-cell RNA sequencing can reveal changes within individual cell populations during pulmonary fibrosis that are ...
P. Reyfman, J. Walter, N. Joshi, K. R. Anekalla, Alexandra McQuattie-Pimentel, Stephen Chiu, Ramiro Fernandez, Mahzad Akbarpour, Ching‐I Chen, Z. Ren, R. Verma, H. Abdala-Valencia, Kiwon Nam, Monica Chi, SeungHye Han, Francisco J. Gonzalez-Gonzalez, S. Soberanes, Satoshi Watanabe, Kinola J. N. Williams, A. S. Flozak, T. Nicholson, Vince K. Morgan, D. Winter, M. Hinchcliff, C. Hrusch, R. Guzy, C. Bonham, A. Sperling, R. Bag, R. Hamanaka, G. Mutlu, A. Yeldandi, Stacy A. Marshall, A. Shilatifard, L. Amaral, H. Perlman, J. Sznajder, A. Argento, C. Gillespie, J. Dematte, M. Jain, Benjamin D. Singer, K. Ridge, A. Lam, A. Bharat, S. Bhorade, C. Gottardi, G. S. Budinger, A. Misharin   +48 more
semanticscholar   +1 more source