Results 51 to 60 of about 174,250 (219)

A network model of correlated growth of tissue stiffening in pulmonary fibrosis [PDF]

, 2013
During the progression of pulmonary fibrosis, initially isolated regions of high stiffness form and grow in the lung tissue due to collagen deposition by fibroblast cells. We have previously shown that ongoing collagen deposition may not lead to significant increases in the bulk modulus of the lung until these local remodeled regions have become ...
arxiv   +1 more source

Bleomycin increases neutrophil adhesion to human vascular endothelial cells independently of upregulation of ICAM-1 and E-selectin [PDF]

, 2016
© 2016 Taylor & Francis. Aim of the Study: Bleomycin-induced lung disease is a serious complication of therapy characterized by alveolar injury, cytokine release, inflammatory cell recruitment, and eventually pulmonary fibrosis.
Crooks, Michael G., Greenman, John, Hart, Simon P., Sadofsky, Laura R., Williamson, James D.   +4 more
core   +1 more source

Materials Advances in Devices for Heart Disease Interventions

Advanced Materials, EarlyView.
This review examines the crucial role of materials in heart disease interventions, focusing on strategies for monitoring, managing, and repairing heart conditions. It discusses the material requirements for medical devices, highlighting recent innovations and their impact on cardiovascular health.
Gagan K. Jalandhra, Lauryn Srethbhakdi, James Davies, Chi Cong Nguyen, Phuoc Thien Phan, Zachary Och, Aditya Ashok, Khoon S. Lim, Hoang‐Phuong Phan, Thanh Nho Do, Nigel H. Lovell, Jelena Rnjak‐Kovacina   +11 more
wiley   +1 more source

Development of a Consensus Statement for the Definition, Diagnosis, and Treatment of Acute Exacerbations of Idiopathic Pulmonary Fibrosis Using the Delphi Technique. [PDF]

, 2015
© 2015, The Author(s).Introduction: There is a lack of agreed and established guidelines for the treatment of acute exacerbations of idiopathic pulmonary fibrosis (AE-IPF).
Bennett, BM, Hoyles, RK, Maher, TM, Mathieson, N, Ochiai, Y, Parfrey, H, Turnbull, A, Whyte, MK, Williamson, N   +8 more
core   +2 more sources

Inhalable Hsa‐miR‐30a‐3p Liposomes Attenuate Pulmonary Fibrosis

Advanced Science, EarlyView.
The study explores inhalable hsa‐miR‐30a‐3p‐loaded liposomes as a treatment for bleomycin‐induced pulmonary fibrosis in mice. Hsa‐miR‐30a‐3p is electroporated into liposomes and formulated into a dry powder for inhalation. Delivered via dry powder inhalation, it improves pulmonary function, promotes myofibroblast de‐differentiation by targeting CNPY2 ...
Shuo Liu, Kristen D. Popowski, Christina M. Eckhardt, Weihang Zhang, Junlang Li, Yujia Jing, Dylan Silkstone, Elizabeth Belcher, Megan Cislo, Shiqi Hu, Halle Lutz, Asma Ghodsi, Mengrui Liu, Phuong‐Uyen C. Dinh, Ke Cheng   +14 more
wiley   +1 more source

Proceedings: Regenerative Medicine for Lung Diseases: A CIRM Workshop Report. [PDF]

, 2017
The mission of the California Institute of Regenerative Medicine (CIRM) is to accelerate treatments to patients with unmet medical needs. In September 2016, CIRM sponsored a workshop held at the University of California, Los Angeles, to discuss ...
DeWitt, Natalie D, Gomperts, Brigitte, Kadyk, Lisa C   +2 more
core   +1 more source

ROS‐Driven Nanoventilator for MRSA‐Induced Acute Lung Injury Treatment via In Situ Oxygen Supply, Anti‐Inflammation and Immunomodulation

Advanced Science, EarlyView.
A ROS‐driven in situ oxygen supply nanoventilator based on enzyme nanocapsule can convert ROS into O2 through enzyme cascade reaction between SOD and CAT to relieve lung hypoxia, and kill MRSA by releasing vancomycin, which effectively reduces HIF‐1α expression and balances pro‐inflammatory/anti‐inflammatory macrophages ratio, thereby reducing the ...
Zheng Luo, Qi Wang, Xiaotong Fan, Xue Qi Koh, Xian Jun Loh, Caisheng Wu, Zibiao Li, Yun‐Long Wu   +7 more
wiley   +1 more source

Strategies for anti-fibrotic therapies. [PDF]

, 2013
The fibrotic diseases encompass a wide spectrum of entities including such multisystemic diseases as systemic sclerosis, nephrogenic systemic fibrosis and sclerodermatous graft versus host disease, as well as organ-specific disorders such as pulmonary ...
Jimenez, Sergio A., Mendoza, MD, Fabian A., Rosenbloom, Joel   +2 more
core   +2 more sources

PRMT1 Ablation in Endothelial Cells Causes Endothelial Dysfunction and Aggravates COPD Attributable to Dysregulated NF‐κB Signaling

Advanced Science, EarlyView.
This study investigates the role of protein arginine methyltransferase 1 (PRMT1) in endothelial cells (ECs) in chronic obstructive pulmonary disease (COPD). Mice with endothelial‐specific PRMT1 deletion develop pulmonary hemorrhage, inflammation, and apoptosis, driven by excessive nuclear factor kappa B activation.
Thi Thuy Vy Tran, Yideul Jeong, Suwoo Kim, Ji Eun Yeom, Jinwoo Lee, Wonhwa Lee, Gyu‐Un Bae, Jong‐Sun Kang   +7 more
wiley   +1 more source

Heterologous matrix metalloproteinase gene promoter activity allows In Vivo real-time imaging of Bleomycin-induced Lung fibrosis in transiently transgenized mice [PDF]

, 2017
Idiopathic pulmonary fibrosis is a very common interstitial lung disease derived from chronic inflammatory insults, characterized by massive scar tissue deposition that causes the progressive loss of lung function and subsequent death for respiratory ...
Donofrio, Gaetano, Macchi, Francesca, Pompilio, Daniela, Ravanetti, Francesca, Ruscitti, Francesca, Stellari, Fabio Franco, Tebaldi, Giulia, Verna, Andrea Elizabeth, Villetti, Gino   +8 more
core   +1 more source