Results 51 to 60 of about 1,607,143 (268)
ROCKing pulmonary fibrosis [PDF]
Journal of Clinical Investigation, 2013 Clinical vignette: A 76-year-old man consults you for increasing shortness of breath over the past two years and an increasing requirement for home oxygen. A video-assisted thoracoscopic lung biopsy shows findings of usual interstitial pneumonitis, and he has no identifiable cause for pulmonary fibrosis, so he is considered to have idiopathic pulmonary
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The interplay of DAMPs, TLR4, and proinflammatory cytokines in pulmonary fibrosis
Journal of molecular medicine, 2021 Pulmonary fibrosis is a chronic debilitating condition characterized by progressive deposition of connective tissue, leading to a steady restriction of lung elasticity, a decline in lung function, and a median survival of 4.5 years. The leading causes of
Siavash Bolourani, M. Brenner, Ping Wang
semanticscholar +1 more source
Airway measurement by refinement of synthetic images improves mortality prediction in idiopathic pulmonary fibrosis [PDF]
arXiv, 2022 Several chronic lung diseases, like idiopathic pulmonary fibrosis (IPF) are characterised by abnormal dilatation of the airways. Quantification of airway features on computed tomography (CT) can help characterise disease progression. Physics based airway measurement algorithms have been developed, but have met with limited success in part due to the ...
arxiv
BMC Pulmonary Medicine, 2023 Background The present study evaluates personality traits in adult patients with cystic fibrosis (CF) and correlates these results with health-related quality of life (HRQoL) and other clinical parameters indicative of disease severity.
Ute Niehammer +6 more
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ZNF143 in Chromatin Looping and Gene Regulation
Frontiers in Genetics, 2020 ZNF143, a human homolog of the transcriptional activator Staf, is a C2H2-type protein consisting of seven zinc finger domains. As a transcription factor (TF), ZNF143 is sequence specifically binding to chromatin and activates the expression of protein ...
Bingyu Ye +30 more
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Frontiers in Immunology, 2023 IntroductionCystic fibrosis (CF), especially CF lung disease, is characterized by chronic infection, immune dysfunction including impairment of regulatory T cells (Tregs) and an exaggerated inflammatory response.
Dirk Westhölter +9 more
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Evaluation of an Open-Source Pipeline to Create Patient-Specific Left Atrial Models: A Reproducibility Study [PDF]
arXiv, 2023 We present an open-source software pipeline to create patient-specific left atrial (LA) models with fibre orientations and a fibrosis map, suitable for electrophysiology simulations. The semi-automatic pipeline takes as input a contrast enhanced magnetic resonance angiogram, and a late gadolinium enhanced (LGE) contrast magnetic resonance (CMR).
arxiv
Sphingolipids in pulmonary fibrosis [PDF]
Advances in Biological Regulation, 2015 Idiopathic pulmonary fibrosis (IPF) is a devastating disease characterized by alveolar epithelial cell injury, accumulation of fibroblasts/myofibroblasts and deposition of extracellular matrix proteins. Levels of sphingosine-1-phosphate (S1P), a naturally occurring bioactive lipid, are elevated in bronchoalveolar fluids and lung tissues from IPF ...
Long Shuang Huang, Viswanathan Natarajan
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Proliferating SPP1/MERTK-expressing macrophages in idiopathic pulmonary fibrosis
European Respiratory Journal, 2019 A comprehensive understanding of the changes in gene expression in cell types involved in idiopathic pulmonary fibrosis (IPF) will shed light on the mechanisms underlying the loss of alveolar epithelial cells and development of honeycomb cysts and ...
C. Morse +13 more
semanticscholar +1 more source
Biomolecules, 2021 . In passages above ten and growing very actively, we observed that some human lung fibroblasts cultured under standard conditions were transformed into a lineage of epithelial-like cells (ELC).
Carina Becerril +7 more
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