Results 61 to 70 of about 1,607,143 (268)

Prospective multicenter randomized patient recruitment and sample collection to enable future measurements of sputum biomarkers of inflammation in an observational study of cystic fibrosis

open access: yesBMC Medical Research Methodology, 2019
Background Biomarkers of inflammation predictive of cystic fibrosis (CF) disease outcomes would increase the power of clinical trials and contribute to better personalization of clinical assessments.
Theodore G. Liou   +33 more
doaj   +1 more source

Downregulation of HMGCS2 mediated AECIIs lipid metabolic alteration promotes pulmonary fibrosis by activating fibroblasts

open access: yesRespiratory Research
Background Abnormal lipid metabolism has recently been reported as a crucial signature of idiopathic pulmonary fibrosis (IPF). However, the origin and biological function of the lipid and possible mechanisms of increased lipid content in the pathogenesis
Juntang Yang   +8 more
doaj   +1 more source

miR-34a in serum is involved in mild-to-moderate COPD in women exposed to biomass smoke

open access: yesBMC Pulmonary Medicine, 2019
Background Chronic obstructive pulmonary disease (COPD) is characterized by persistent respiratory symptoms and airflow limitation that is due to airway and/or alveolar abnormalities.
Yadira Velasco-Torres   +8 more
doaj   +1 more source

Real-life impact of highly effective CFTR modulator therapy in children with cystic fibrosis

open access: yesFrontiers in Pharmacology, 2023
Introduction: Recently, cystic fibrosis transmembrane regulator modulator therapy with elexacaftor/tezacaftor/ivacaftor has become available for children with cystic fibrosis (CF) carrying at least one F508del mutation.Objective: To assess the ...
Margarete Olivier   +7 more
doaj   +1 more source

The importance of interventional timing in the bleomycin model of pulmonary fibrosis

open access: yesEuropean Respiratory Journal, 2020
Idiopathic pulmonary fibrosis (IPF) is a complex disease of unknown aetiology, which makes drug development challenging. Single administration of bleomycin directly to the lungs of mice is a widely used experimental model for studying pulmonary ...
Philipp Kolb   +9 more
semanticscholar   +1 more source

Homozygous mutation in DNAAF4 causes primary ciliary dyskinesia in a Chinese family

open access: yesFrontiers in Genetics, 2022
Primary ciliary dyskinesia (PCD) is a rare autosomal recessive disorder that affects the structure and function of motile cilia, leading to classic clinical phenotypes, such as situs inversus, chronic sinusitis, bronchiectasis, repeated pneumonia and ...
Guoliang Jiang   +25 more
doaj   +1 more source

A network model of correlated growth of tissue stiffening in pulmonary fibrosis [PDF]

open access: yes, 2013
During the progression of pulmonary fibrosis, initially isolated regions of high stiffness form and grow in the lung tissue due to collagen deposition by fibroblast cells. We have previously shown that ongoing collagen deposition may not lead to significant increases in the bulk modulus of the lung until these local remodeled regions have become ...
arxiv   +1 more source

Interstitial pulmonary fibrosis

open access: yesChest, 1986
The study of animal models of IPF has demonstrated that there is a stereotyped response of the respiratory airspace walls to a wide variety of injuries. Inflammatory and immune effector cells play a major and complex role in the fibrosing process. They may contribute to the injury of the lung beyond the original insult.
openaire   +3 more sources

NR2F2 alleviates pulmonary fibrosis by inhibition of epithelial cell senescence

open access: yesRespiratory Research
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fatal, and aging-associated interstitial lung disease with a poor prognosis and limited treatment options, while the pathogenesis remains elusive.
Ruyan Wan   +11 more
doaj   +1 more source

Modelling Airway Geometry as Stock Market Data using Bayesian Changepoint Detection [PDF]

open access: yesIn Lecture Notes in Computer Science, vol 11861. (2019) Springer, Cham, 2019
Numerous lung diseases, such as idiopathic pulmonary fibrosis (IPF), exhibit dilation of the airways. Accurate measurement of dilatation enables assessment of the progression of disease. Unfortunately the combination of image noise and airway bifurcations causes high variability in the profiles of cross-sectional areas, rendering the identification of ...
arxiv   +1 more source

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