Results 61 to 70 of about 1,677,383 (218)

Overexpression miR-125a-5p inhibits HSCs activation and alleviates liver fibrosis through TGF-β/Smad2/3 signaling pathway and autophagy

Cell Death Discovery
Liver fibrosis represents an important pathological stage during chronic hepatopathy development, posing a significant threat to human health. Hepatic stellate cells (HSCs), an essential hepatic non-parenchymal cells, have a key effect on fibrogenesis ...
Chunyan Zhang, Yabin Zhao, Haoyu Yan, Jianlin Guo, GuoYing Yu   +4 more
doaj   +1 more source

Infant Pulmonary Function Testing in Pediatric Diffuse Parenchymal Lung Disease

CHEST Pulmonary
Topic Importance: Diffuse parenchymal lung disease (DPLD) in pediatrics, also known as children’s interstitial lung disease, comprises a diverse group of rare and chronic respiratory disorders affecting the pediatric population. Diagnosing and monitoring
Avigdor Hevroni, MD, Alex Gileles-Hillel, MD, Malena Cohen-Cymberknoh, MD, Joel Reiter, MD, David Shoseyov, MD, Reuven Tsabari, MD, Chaim Springer, MD, Laurice S. Boursheh, MD, Oded Breuer, MD   +8 more
doaj   +1 more source

The importance of interventional timing in the bleomycin model of pulmonary fibrosis

European Respiratory Journal, 2020
Idiopathic pulmonary fibrosis (IPF) is a complex disease of unknown aetiology, which makes drug development challenging. Single administration of bleomycin directly to the lungs of mice is a widely used experimental model for studying pulmonary ...
Philipp Kolb, C. Upagupta, M. Vierhout, Ehab A. Ayaub, P. Bellaye, J. Gauldie, C. Shimbori, M. Inman, K. Ask, M. Kolb   +9 more
semanticscholar   +1 more source

Pirfenidone alleviates pulmonary fibrosis in vitro and in vivo through regulating Wnt/GSK-3β/β-catenin and TGF-β1/Smad2/3 signaling pathways

Molecular Medicine, 2020
Background Pirfenidone (PFD) is effective for pulmonary fibrosis (PF), but its action mechanism has not been fully explained. This study explored the signaling pathways involved in anti-fibrosis role of PFD, thus laying a foundation for clinical ...
Qun Lv, Jianjun Wang, Changqing Xu, Xuqing Huang, Zhaoyang Ruan, Yifan Dai   +5 more
semanticscholar   +1 more source

Identification of diagnostic hub genes related to neutrophils and infiltrating immune cell alterations in idiopathic pulmonary fibrosis [PDF]

, 2023
Yingying Lin, Xiaofan Lai, Shaojie Huang, Lvya Pu, Qihao Zeng, Zhongxing Wang, Wenqi Huang   +6 more
openalex   +1 more source

Transition Planning for Chronic Illnesses in the Time of COVID-19

Journal of Patient Experience, 2020
Transition from pediatric to adult care for those with chronic illnesses must have special considerations during the COVID-19 pandemic. The SARS-CoV-2 coronavirus has significantly disrupted social, economic, and health care practices globally.
William R Hunt MD, Rachel W Linnemann MD, Brandi Middour-Oxler DNP   +2 more
doaj   +1 more source

Itaconate controls the severity of pulmonary fibrosis

Science immunology, 2020
The ACOD1/itaconate axis is a pulmonary regulatory pathway that controls the severity of fibrosis and is a potential therapeutic target in IPF.
P. Ogger, G. Albers, R. Hewitt, B. O’Sullivan, J. Powell, E. Calamita, P. Ghai, S. Walker, P. McErlean, P. Saunders, S. Kingston, P. Molyneaux, J. Halket, R. Gray, D. Chambers, T. Maher, C. Lloyd, A. Byrne   +17 more
semanticscholar   +1 more source

Integrative analysis of gene expression and chromatin dynamics multi-omics data in mouse models of bleomycin-induced lung fibrosis

Epigenetics & Chromatin
Background Pulmonary fibrosis is a relentless and ultimately fatal lung disorder. Despite a wealth of research, the intricate molecular pathways that contribute to the onset of PF, especially the aspects related to epigenetic modifications and chromatin ...
Zhongzheng Li, Mengke Zhang, Yujie Zhang, Yulong Gan, Zhao Zhu, Jiawei Wang, Yanlin Zhou, Guoying Yu, Lan Wang   +8 more
doaj   +1 more source

Loss of PTPN21 disrupted mitochondrial metabolic homeostasis and aggravated experimental pulmonary fibrosis

Respiratory Research
Idiopathic pulmonary fibrosis (IPF) is a high-mortality lung disease with unclear pathogenesis. Convincing evidence suggests that an imbalance in mitochondrial homeostasis resulting from repeated injury to alveolar epithelial type 2 cells (AEC2 ...
Hui Lian, Kai Xu, Airu Chang, Yaxuan Wang, Shuaichen Ma, Lianhui Cheng, Wenyu Zhao, Cong Xia, Lan Wang, Guoying Yu   +9 more
doaj   +1 more source

TRβ activation confers AT2-to-AT1 cell differentiation and anti-fibrosis during lung repair via KLF2 and CEBPA

Nature Communications
Aberrant repair underlies the pathogenesis of pulmonary fibrosis while effective strategies to convert fibrosis to normal regeneration are scarce. Here, we found that thyroid hormone is decreased in multiple models of lung injury but is essential for ...
Xin Pan, Lan Wang, Juntang Yang, Yingge Li, Min Xu, Chenxi Liang, Lulu Liu, Zhongzheng Li, Cong Xia, Jiaojiao Pang, Mengyuan Wang, Meng Li, Saiya Guo, Peishuo Yan, Chen Ding, Ivan O. Rosas, Guoying Yu   +16 more
doaj   +1 more source