Results 61 to 70 of about 397,364 (338)

Machine Learning‐Enabled Polymer Discovery for Enhanced Pulmonary siRNA Delivery

Advanced Functional Materials, EarlyView.
This study provides an efficient approach to train a machine learning model by merging heterogeneous literature data to predict suitable polymers for siRNA delivery. Without the need for extensive laboratory synthesis, the machine learning enabled a virtual screening and successfully predicted a polymer that is validated for effective gene silencing in
Felix Sieber‐Schäfer, Min Jiang, Adrian Kromer, Anny Nguyen, Müge Molbay, Simone Pinto Carneiro, David Jürgens, Gerald Burgstaller, Bastian Popper, Benjamin Winkeljann, Olivia Monika Merkel   +10 more
wiley   +1 more source

miR-34a in serum is involved in mild-to-moderate COPD in women exposed to biomass smoke

BMC Pulmonary Medicine, 2019
Background Chronic obstructive pulmonary disease (COPD) is characterized by persistent respiratory symptoms and airflow limitation that is due to airway and/or alveolar abnormalities.
Yadira Velasco-Torres, Victor Ruiz López, Oliver Pérez-Bautista, Ivette Buendía-Roldan, Alejandra Ramírez-Venegas, Julia Pérez-Ramos, Ramcés Falfán-Valencia, Carlos Ramos, Martha Montaño   +8 more
doaj   +1 more source

Real-life impact of highly effective CFTR modulator therapy in children with cystic fibrosis

Frontiers in Pharmacology, 2023
Introduction: Recently, cystic fibrosis transmembrane regulator modulator therapy with elexacaftor/tezacaftor/ivacaftor has become available for children with cystic fibrosis (CF) carrying at least one F508del mutation.Objective: To assess the ...
Margarete Olivier, Alexandra Kavvalou, Matthias Welsner, Raphael Hirtz, Svenja Straßburg, Sivagurunathan Sutharsan, Florian Stehling, Mathis Steindor   +7 more
doaj   +1 more source

Interstitial pulmonary fibrosis

Chest, 1986
The study of animal models of IPF has demonstrated that there is a stereotyped response of the respiratory airspace walls to a wide variety of injuries. Inflammatory and immune effector cells play a major and complex role in the fibrosing process. They may contribute to the injury of the lung beyond the original insult.
openaire   +3 more sources

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

NR2F2 alleviates pulmonary fibrosis by inhibition of epithelial cell senescence

Respiratory Research
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fatal, and aging-associated interstitial lung disease with a poor prognosis and limited treatment options, while the pathogenesis remains elusive.
Ruyan Wan, Siqi Long, Shuaichen Ma, Peishuo Yan, Zhongzheng Li, Kai Xu, Hui Lian, Wenwen Li, Yudi Duan, Miaomiao Zhu, Lan Wang, Guoying Yu   +11 more
doaj   +1 more source

Early respiratory viral infections in infants with cystic fibrosis [PDF]

, 2015
This article is made available for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source.
A Peshkin, C Castoriadis, C Hauke, C Lasch, C Mayes, C Mayes, CG Jung, CG Jung, DC Dennett, I Semetsky, I Semetsky, J Blackmore, J Campbell, J Campbell, J Cole, J Conroy, J Conroy, J Day, J Lecoq, J Parini, JC Conroy, JR Searle, JV Wertsch, K Johnstone, K Kristjansson, LA Russell-Chapin, M Currie, M Harding, M Lynch, M Merleau-Ponty, R Leitch, R Leitch, R Leitch, R Segal, RH Hopcke, S Rowland, S Walsh, T Barone, V John-Steiner, V Villate, W James, W Sorrell   +41 more
core   +1 more source

Soft Nanocarriers as Antimicrobial Co‐Delivery Systems to Combat Resistant Infections

Advanced Healthcare Materials, EarlyView.
Soft nanocarrier‐based co‐delivery systems present a versatile and promising platform for combating antimicrobial resistance (AMR) by enabling spatiotemporally controlled, pathogen‐specific drug release. Their tunable physicochemical properties allow for the co‐encapsulation of synergistic antimicrobial agents, optimization of drug ratios, and surface ...
Anamarija Nikoletic, Evangelos Natsaridis, Timon Flathmann, Daiane P. C. Quadros, Nubia Gogniat, Oya Tagit   +5 more
wiley   +1 more source

Homozygous mutation in DNAAF4 causes primary ciliary dyskinesia in a Chinese family

Frontiers in Genetics, 2022
Primary ciliary dyskinesia (PCD) is a rare autosomal recessive disorder that affects the structure and function of motile cilia, leading to classic clinical phenotypes, such as situs inversus, chronic sinusitis, bronchiectasis, repeated pneumonia and ...
Guoliang Jiang, Guoliang Jiang, Lijun Zou, Lijun Zou, Lingzhi Long, Lingzhi Long, Yijun He, Yijun He, Xin Lv, Xin Lv, Yuanyuan Han, Yuanyuan Han, Tingting Yao, Tingting Yao, Yan Zhang, Yan Zhang, Mao Jiang, Mao Jiang, Zhangzhe Peng, Zhangzhe Peng, Lijian Tao, Lijian Tao, Wei Xie, Wei Xie, Jie Meng, Jie Meng   +25 more
doaj   +1 more source

Pirfenidone in idiopathic pulmonary fibrosis:expert panel discussion on the management of drug-related adverse events [PDF]

, 2014
Pirfenidone is currently the only approved therapy for idiopathic pulmonary fibrosis, following studies demonstrating that treatment reduces the decline in lung function and improves progression-free survival.
A Azuma, A Karakatsani, Alexandre Sarafidis, B Ley, C Jiang, C Plessen von, Carlo Vancheri, CJ Schaefer, CM Rubino, DS Kim, EB Meltzer, Elisabeth Bendstrup, G Raghu, H Liu, H Oku, H Oku, H Taniguchi, HR Collard, J Gribbin, James Ferguson, Jim J. J. Egan, JS Lee, KJ Grattendick, Klas Nordlind, KM Antoniou, L Nalysnyk, M Ito, Maria Molina-Molina, ME Cho, Michael Kreuter, MJ Thomeer, N Chaudhuri, Per M. Hellström, Pieter Dewint, PW Noble, Richard Groves, RM Bois du, S Nakayama, T Itoh, Toby M. Maher, U Hodgson, Ulrich Costabel, V Cottin, V Navaratnam, Vincent Cottin, Y Seto   +45 more
core   +7 more sources