Results 171 to 180 of about 2,650,471 (308)

A Case of Pulmonary Infection Caused by Rhodococcus equi in an AIDS Patient and Literature Review [PDF]

open access: yes
Hong Zhu,1,* Yongzheng Guo,2,* Hongchao Chen,3 Lingmei Ni,1 Biao Zhu,2 Tingting Qu4 1Infection Control Department, the First Affiliated Hospital, Zhejiang University School of Medicine, Hang Zhou, Zhe Jiang, People’s Republic of China; 2The ...
Ni L, Guo Y, Zhu H, Chen H, Zhu B, Qu T
core  

Chimeric IL‐6/4R‐LL37 Engineered Macrophages Achieve Synchronized Inflammation Control and Antimicrobial Defence in Sepsis

open access: yesAdvanced Science, EarlyView.
Engineered macrophages programmed in situ by LNP‐delivered IL‐6/4 fusion and LL37 mRNAs simultaneously dampen cytokine storm, promote M2‐like repair, and enhance direct bacterial killing in sepsis. This combinatorial strategy restores T cell and macrophage function, lowers organ bacterial burden, and improves survival, highlighting a precision, host ...
Tianyang Jie   +10 more
wiley   +1 more source

Effects of tuberculosis and HIV infection on whole-body protein metabolism during feeding, measured by the [15N]glycine method

open access: yes, 2003
Background: Tuberculosis (TB) and HIV infection are wasting diseases that frequently occur together and have severe consequences on nutritional status.Objective: The objective was to determine the effects of TB and HIV, separately and together, on ...
Jackson, Alan A.   +4 more
core  

Pulmonary infection due to emerging <i>Lophomonas</i> pathogen in immunocompetent patients: Two case reports. [PDF]

open access: yesSAGE Open Med Case Rep
Zakariaei Z   +6 more
europepmc   +1 more source

circZNF148 Drives Glucose Metabolism Reprogramming to Enhance Metastasis and Immune Evasion via HK1 Stabilization in Triple‐Negative Breast Cancer

open access: yesAdvanced Science, EarlyView.
CircZNF148 stabilizes HK1 through deubiquitinase recruitment, thereby enhancing glycolysis and lactate production. Elevated lactate promotes PD‑L1 lactylation and membrane accumulation while suppressing CD8+ T‐cell cytotoxicity, collectively facilitating immune evasion and malignant progression in TNBC.
Yuhan Jin   +17 more
wiley   +1 more source

Senkyunolide I Inhibits mtDNA‐cGAS‐STING Signaling in Macrophages via Targeting VDAC1 Oligomerization to Attenuate Ulcerative Colitis

open access: yesAdvanced Science, EarlyView.
In macrophages, senkyunolide I (SEI) directly targets the K12 residue of VDAC1 to inhibit its stress‐induced oligomerization, a critical upstream event that effectively prevents mitochondrial DNA release and subsequent cGAS‐STING pathway activation.
Zhiming Ye   +9 more
wiley   +1 more source

Return to an extreme environment exposure after pulmonary infection: SCUBA diving as a model? [PDF]

open access: yesPhysiol Rep
Cialoni D   +10 more
europepmc   +1 more source

Generation of Nasal Cell‐Derived Human Alveolar Organoids and Organoid‐Macrophage Assembloids for in Vitro Lung Modeling

open access: yesAdvanced Science, EarlyView.
This study demonstrates the generation of human alveolar organoids from nasal cells, which, when co‐cultured with monocyte‐derived macrophages, promotes maturation of both components and forms alveolar assembloids resembling native alveoli. These alveolar organoids and assembloids offer accessible, physiologically relevant in vitro systems for ...
Man Chun Chiu   +19 more
wiley   +1 more source

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