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Comparative biophysical study of clinical surfactants using constrained drop surfactometry.
Am J Physiol Lung Cell Mol PhysiolZuo YY.
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Canadian Journal of Biochemistry and Cell Biology, 1984
The mammalian lung is stabilized by a specialized material, the pulmonary surfactant, which acts by reversibly reducing the surface tension at the air–liquid interface of the lung during breathing. Pulmonary surfactant contains approximately 90% lipid and 10% proteins. Dipalmitoyl phosphatidylcholine, the major lipid component, appears to be primarily
F, Possmayer +3 more
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The mammalian lung is stabilized by a specialized material, the pulmonary surfactant, which acts by reversibly reducing the surface tension at the air–liquid interface of the lung during breathing. Pulmonary surfactant contains approximately 90% lipid and 10% proteins. Dipalmitoyl phosphatidylcholine, the major lipid component, appears to be primarily
F, Possmayer +3 more
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New England Journal of Medicine, 1993
In 1959, not long after surfactant had been identified as critical to maintaining lung inflation at low transpulmonary pressures,1,2 Avery and Mead3 reported that saline extracts from the lungs of preterm infants with respiratory distress syndrome lacked the low surface tension characteristic of pulmonary surfactant. After several unsuccessful attempts
Alastair J.J. Wood, Alan H. Jobe
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In 1959, not long after surfactant had been identified as critical to maintaining lung inflation at low transpulmonary pressures,1,2 Avery and Mead3 reported that saline extracts from the lungs of preterm infants with respiratory distress syndrome lacked the low surface tension characteristic of pulmonary surfactant. After several unsuccessful attempts
Alastair J.J. Wood, Alan H. Jobe
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Biomimetic pulmonary surfactants
Life Sciences, 1994Considerable progress has been made in the development of defined mixtures of proteins or peptides with phospholipids which mimic the activity of natural pulmonary surfactants. Several of these biomimetic surfactants are active in animal models and clinical syndromes of surfactant deficiency.
L R, McLean, J E, Lewis
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Pulmonary Surfactant Metabolism
Clinics in Chest Medicine, 1989Recent work suggests that surfactant undergoes a complex sequence of metabolic events during its life cycle in the alveolar airspace. The composition, turnover, and metabolism of surfactant, and the possible "control points" in its metabolic pathway that might be compromised in disease states are discussed.
J R, Wright, S, Hawgood
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BioDrugs, 1999
Surfactant preparations, which are effective in the treatment of respiratory distress syndrome (RDS), contain phospholipids and small amounts of the 2 hydrophobic surfactant proteins SP-B and SP-C. At present, surfactant preparations are obtained from animal lungs.
J, Johansson +5 more
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Surfactant preparations, which are effective in the treatment of respiratory distress syndrome (RDS), contain phospholipids and small amounts of the 2 hydrophobic surfactant proteins SP-B and SP-C. At present, surfactant preparations are obtained from animal lungs.
J, Johansson +5 more
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Annual Review of Medicine, 1989
Pulmonary surfactant is a chemically heterogeneous material that provides a stable, low surface tension within the lung, thereby preventing alveolar collapse at low transpulmonary pressures. Both the lipid and the protein components of surfactant are important for establishing and maintaining a low surface tension.
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Pulmonary surfactant is a chemically heterogeneous material that provides a stable, low surface tension within the lung, thereby preventing alveolar collapse at low transpulmonary pressures. Both the lipid and the protein components of surfactant are important for establishing and maintaining a low surface tension.
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Pulmonary surfactant and tuberculosis
Tuberculosis, 2009Mycobacterium tuberculosis comes in contact with pulmonary surfactant, alveolar macrophages and type II epithelial cells. Alveolar type II epithelial cells secrete pulmonary surfactant, a complex mixture of phospholipids and proteins lining the alveolar surface, while alveolar macrophages are involved in surfactant catabolism.
Zissis C, Chroneos +3 more
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Pulmonary Surfactant and Atelectasis
Anesthesiology, 1964Surface activity of atelectatic lung extracts was studied with a surface film balance. All 16 atelectatic specimens demonstrated decreased surface activity regardless of etiology. Of those 12 not associated with pneumonia, contiguous lung tissue was normally surface active. Only atelectatic portions, no matter how tiny, were inactive.
A I, SUTNICK, L A, SOLOFF
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