Results 61 to 70 of about 354,605 (357)

Accelerating Primary Screening of USP8 Inhibitors from Drug Repurposing Databases with Tree‐Based Machine Learning

Advanced Intelligent Discovery, EarlyView.
This study introduces a tree‐based machine learning approach to accelerate USP8 inhibitor discovery. The best‐performing model identified 100 high‐confidence repurposable compounds, half already approved or in clinical trials, and uncovered novel scaffolds not previously studied. These findings offer a solid foundation for rapid experimental follow‐up,
Yik Kwong Ng, Sharon Ai Er Lam, Wei Chun Lim, Hannah Hui Min Toh, Shi Jun Ang   +4 more
wiley   +1 more source

Bedaquiline combined with clofazimine as salvage therapy for 11 patients with nontuberculous mycobacterial lung disease

BMC Infectious Diseases
Objective We aimed to investigate the efficacy and safety of a regimen combining bedaquiline and clofazimine in the treatment of refractory nontuberculous mycobacterial lung disease caused by Mycobacterium avium complex(MAC) or Mycobacterium abscessus ...
Lan Yao, Yifan He, Jinghui Yang, Xubin Zheng, Xiang Shi, Wei Wei, Guoling Yang, Ruoyan Ying, Wei Sha   +8 more
doaj   +1 more source

Hubungan Kepatuhan Pengobatan Dengan Hilangnya Gejala Klinis Tuberkulosis Paru Di Poli Paru Rsup Prof. Dr. R. D. Kandou Manado [PDF]

, 2014
: Pulmonary tuberculosis ( tb ) , is an infective disease caused by bacteria mikrobakterium tuberculosis. Pulmonary tuberculosis is a disease killer second largest after the human immunodeficiency virus hiv ) / ( acquired immune deficiency syndrom ( aids
Beelt, M. C. (Melinda), Ismanto, Y. (Yudi), Kallo, V. (Vandri)   +2 more
core  

Estimation of Reserves for Improving the Results of Patients with Multipresistant Pulmonary Tuberculosis in the Application of Surgical Methods Based on Analysis of the Efficiency of Conservative Treatment of a Specified Cohort [PDF]

, 2018
In order to improve the results of treatment of patients with multi-resistant pulmonary tuberculosis with the use of surgical methods, the effectiveness estimation of conservative treatment of 176 patients with this form of tuberculosis according to ...
Ivashchenko, V. (Vladimir), Kalabukha, I. (Igor), Khmel, O. (Oleg)   +2 more
core   +2 more sources

Proteomic Analysis of Golden Sputum Reveals Pulmonary Complement Activation During Acute Chest Syndrome in Children With Sickle Cell Disease

American Journal of Hematology, EarlyView.
ABSTRACT Acute chest syndrome (ACS) is one of the most common severe complications of sickle cell disease (SCD). In recent years, a major role of inflammation and innate immunity has been evidenced, but ACS pathophysiology remains incompletely understood, and therapeutic options are limited.
Slimane Allali, Nabiha Sbeih, Rachel Rignault‐Bricard, Johanna Bruce, Morgane Le Gall, Claire Heilbronner, Noemie de Cacqueray, Sofia Angyalosy, Melissa Taylor, Joséphine Brice, Mariane de Montalembert, Martina Bevacqua, Emilie‐Fleur Gautier, Olivier Hermine, Thiago Trovati Maciel   +14 more
wiley   +1 more source

Using simultaneous amplification and testing method for evaluating the treatment outcome of pulmonary tuberculosis

BMC Infectious Diseases, 2018
Background To evaluate the utility of Simultaneous Amplification and Testing (SAT-TB) Method for monitoring anti-TB treatment response. Methods Serial morning sputum specimens were obtained from 377 active pulmonary tuberculosis (PTB) cases at baseline ...
Liping Yan, Heping Xiao, Qing Zhang
doaj   +1 more source

New approaches to treating chronic obstructive pulmonary disease with Colla corii asini

Animal Models and Experimental Medicine, EarlyView.
Colla corii asini improves chronic obstructive pulmonary disease (COPD) treatment through anti‐inflammatory, antioxidant, immune‐modulatory, and lung‐nourishing effects, addressing current therapeutic challenges via multitarget mechanisms. Abstract Chronic obstructive pulmonary disease (COPD) is one of the leading causes of death and disability ...
Wenchao Zhang, Siman Sun, Xiaoyu Fan, Jiuming He, Qing Li, Hongtao Jin   +5 more
wiley   +1 more source

Performance of the MeltPro TB assay as initial test for diagnosis of pulmonary tuberculosis with drug-resistance detection

Molecular Medicine, 2023
Background The MeltPro TB assay (MeltPro) is a molecular rapid diagnostic test designed for detecting resistance to antituberculosis drugs. However, the performance of MeltPro as an initial diagnostic test for simultaneously detecting the presence of ...
Zhi-bin Liu, Li-ping Cheng, Hong-qiu Pan, Xiao-cui Wu, Fu-hui Lu, Jie Cao, Lei Wang, Wei Wei, Hong-yu Chen, Wei Sha, Qin Sun   +10 more
doaj   +1 more source

Establishment of a biosafe murine model of skeletal tuberculosis using Mycobacterium smegmatis

Animal Models and Experimental Medicine, EarlyView.
This study developed a biosafe, accessible, and versatile murine model of bone TB using Mycobacterium smegmatis, a fast‐growing, nonpathogenic mycobacterial species with high genomic homology to Mycobacterium tuberculosis. Three infection routes—subperiosteal calvarial injection, intratibial injection, and intracardiac (left ventricular) inoculation ...
Yewei Jia, Yuhuai Guo, Yusheng Yang, Jie Zhang, Ziyang Zhang, Ying Qu, Jiulin Tan, Jie Shen, Nathachit Limjunyawong, Jianzhong Xu, Zehua Zhang, Fei Luo, Ce Dou   +12 more
wiley   +1 more source

Determinants Analysis of Pulmonary Tuberculosis Incidence in Tugo Mulyo Primary Care in 2011/2012 [PDF]

, 2013
Background: Pulmonary Tuberculosis is an infectious disease that\u27s caused by Tuberculosis Mycobacteria that primarily attacks the lungs, lymph nodes, and intestines.
Mukholipah, S. (Siti), Mutahar, R. (Rini), Najmah, N. (Najmah)   +2 more
core