Results 41 to 50 of about 440,279 (349)

Fatty acid nitroalkenes ameliorate glucose intolerance and pulmonary hypertension in high-fat diet-induced obesity [PDF]

, 2014
Aims Obesity is a risk factor for diabetes and cardiovascular diseases, with the incidence of these disorders becoming epidemic. Pathogenic responses to obesity have been ascribed to adipose tissue (AT) dysfunction that promotes bioactive mediator ...
Baust, Jeff, Bonacci, Gustavo Roberto, Cantu Medellin, Nadiezhda, Champion, Hunter C., Croix, Claudette M. St., Devlin, Jason E., Freeman, Bruce A., Frisbee,Jefferson C., Gladwin, Mark T., Golin Bisello, Franca, Gor, Sonia, Kelley, Eric E., Khoo, Nicholas K.H., Watkins, Simon C., Weidert, Eric R.   +14 more
core   +1 more source

Comparison Between the Acute Pulmonary Vascular Effects of Oxygen with Nitric Oxide and Sildenafil

Frontiers in Pediatrics, 2015
Objective. Right heart catheterization is performed in patients with pulmonary arterial hypertension to determine the severity of disease and their pulmonary vascular reactivity.
Ronald W. Day
doaj   +1 more source

The molecular genetics and cellular mechanisms underlying pulmonary arterial hypertension [PDF]

, 2012
Pulmonary arterial hypertension (PAH) is an incurable disorder clinically characterised by a sustained elevation of mean arterial pressure in the absence of systemic involvement.
Machado, Rajiv
core   +2 more sources

Cellular Pathways Promoting Pulmonary Vascular Remodeling by Hypoxia.

Physiology, 2020
Exposure to hypoxia increases pulmonary vascular resistance, leading to elevated pulmonary arterial pressure and, potentially, right heart failure.
L. Shimoda
semanticscholar   +1 more source

Extracellular matrix degradation pathways and fatty acid metabolism regulate distinct pulmonary vascular cell types in pulmonary arterial hypertension

Pulmonary Circulation, 2021
Pulmonary arterial hypertension describes a group of diseases characterised by raised pulmonary vascular resistance, resulting from vascular remodelling in the pre-capillary resistance arterioles.
Sharon Mumby, F. Perros, C. Hui, B.L. Xu, W. Xu, V Elyasigomari, A. Hautefort, G. Manaud, M. Humbert, K.F. Chung, S.J. Wort, I.M. Adcock   +11 more
doaj   +1 more source

Calcium-Sensing Receptor Regulates Cytosolic [Ca 2+ ] and Plays a Major Role in the Development of Pulmonary Hypertension. [PDF]

, 2016
Pulmonary arterial hypertension (PAH) is a progressive disease characterized by elevated pulmonary vascular resistance (PVR) leading to right heart failure and premature death.
Ayako Makino, Haiyang Tang, Jason X.-J. Yuan, Jason X.-J. Yuan, Kimberly A. Smith, Ramon J. Ayon   +5 more
core   +3 more sources

Pulmonary hypertension and lung transplantation waitlist outcomes for hypersensitivity pneumonitis

JHLT Open
Background: Hypersensitivity pneumonitis is an interstitial lung disease that can progress to pulmonary hypertension which increases mortality. The European Society of Cardiology recently reduced the diagnostic criteria for precapillary pulmonary ...
Michael J. Nicholson, DO, Zehra Dhanani, MBBS, Shameek Gayen, MD   +2 more
doaj   +1 more source

Shunt resistance is associated with clinically important outcomes after the Norwood operationCentral MessagePerspective

JTCVS Open, 2022
Background: In single-ventricle physiology, focus on pulmonary vascular resistance neglects the resistance in the conduit supplying the pulmonary inflow. Methods: Conduit length and diameter, which can approximate conduit resistance, are available in the
Zachary A. Spigel, MD, MPH, Athar M. Qureshi, MD, Alyssa Kalustian, MD, Ziyad M. Binsalamah, MD, Michiaki Imamura, MD, PhD, Christopher A. Caldarone, MD   +5 more
doaj   +1 more source

Human immunodeficiency virus-1 transgene expression increases pulmonary vascular resistance and exacerbates hypoxia-induced pulmonary hypertension development

Pulmonary Circulation, 2013
Pulmonary arterial hypertension (PAH) is a progressive disease characterized by increased pulmonary arterial resistance and vessel remodeling. Patients living with human immunodeficiency virus-1 (HIV-1) have an increased susceptibility to develop severe ...
K. M. Porter, E. Walp, S. Elms, R. Raynor, P. Mitchell, D. Guidot, R. Sutliff   +6 more
semanticscholar   +1 more source

Insights into the pulmonary vascular complications of heart failure with preserved ejection fraction [PDF]

, 2019
Pulmonary hypertension in the setting of heart failure with preserved ejection fraction (PH-HFpEF) is a growing public health problem that is increasing in prevalence.
Gladwin, Mark T., Lai, Yen‐Chun, Wang, Longfei   +2 more
core   +1 more source