Results 31 to 40 of about 4,197,466 (259)

Pulmonary hypertension and lung transplantation waitlist outcomes for hypersensitivity pneumonitis

JHLT Open
Background: Hypersensitivity pneumonitis is an interstitial lung disease that can progress to pulmonary hypertension which increases mortality. The European Society of Cardiology recently reduced the diagnostic criteria for precapillary pulmonary ...
Michael J. Nicholson, DO, Zehra Dhanani, MBBS, Shameek Gayen, MD   +2 more
doaj   +1 more source

Extracellular matrix degradation pathways and fatty acid metabolism regulate distinct pulmonary vascular cell types in pulmonary arterial hypertension

Pulmonary Circulation, 2021
Pulmonary arterial hypertension describes a group of diseases characterised by raised pulmonary vascular resistance, resulting from vascular remodelling in the pre-capillary resistance arterioles.
Sharon Mumby, F. Perros, C. Hui, B.L. Xu, W. Xu, V Elyasigomari, A. Hautefort, G. Manaud, M. Humbert, K.F. Chung, S.J. Wort, I.M. Adcock   +11 more
doaj   +1 more source

Sixth Annual Scientific Workshops and Debates of the Pulmonary Vascular Research Institute (PVRI)

, 2013
from Sixth Annual Scientific Workshops and Debates of the Pulmonary Vascular Research Institute (PVRI), Istanbul, January 21–25 ...
Abdul Salam, V, Wojciak-Stothard, B, Wilkins, MR, Sixth Annual Scientific Workshops and Debates of the Pulmonary Vascular Research Institute (PVRI), Gierula, M, Edwards, RJ, Zhao, L   +6 more
core   +1 more source

Therapeutic efficacy of TBC3711 in monocrotaline-induced pulmonary hypertension [PDF]

, 2011
Background: Endothelin-1 signalling plays an important role in pathogenesis of pulmonary hypertension. Although different endothelin-A receptor antagonists are developed, a novel therapeutic option to cure the disease is still needed.
Norbert Weissmann, Sydykov, Akylbek, Brandes, Ralf, Schermuly, Ralph T., Hossein A Ghofrani, Janssen, Wiebke, Seeger Werner, Ralf P Brandes, Neil Davie, Dahal, Bhola K., Davie, Neil, Janssen Wiebke, Davie Neil, Ghofrani Hossein A, Seeger, Werner, Cornitescu, Teodora, Brandes Ralf P, Cornitescu Teodora, Kosanovic, Djuro, Kojonazarov, Baktybek, Werner Seeger, Friedrich Grimminger, Ghofrani, Hossein Ardeschir, Grimminger, Friedrich, Dahal Bhola K, Djuro Kosanovic, Baktybek Kojonazarov, Teodora Cornitescu, Schermuly Ralph T, Sydykov Akylbek, Wiebke Janssen, Grimminger Friedrich, Akylbek Sydykov, Kojonazarov Baktybek, Weissmann Norbert, Himal Luitel, Luitel Himal, Ralph T Schermuly, Luitel, Himal, Weißmann, Norbert, Bhola K Dahal, Kosanovic Djuro   +41 more
core   +2 more sources

Pulmonary vascular resistance in the fluorocarbon-filled lung

, 1986
Pulmonary vascular resistance was investigated in the fluorocarbon-filled lung in an in situ isolated lung preparation. Lungs were perfused at constant flow (100 ml X min-1 X kg-1) with whole blood from a donor cat.
T. H. Shaffer, C. A. Lowe
core   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Pulmonary Vascular Hemodynamic data.

, 2015
Abbreviations: LAp = Left atrial pressure, L/min/m2 = Liters per minute per meter squared, PAp = Pulmonary arterial pressure, PAWp = pulmonary artery wedge pressure, PVRI = pulmonary vascular resistance index, QPI = Pulmonary blood flow index, WUm2 ...
Roger Zemp (832820), James Y. Coe (832819), Ian Adatia (832821), Mohamed Elgendi (459412), Jennifer Rutledge (832818), Dale Schuurmans (475410), Long Guo (548453), Shine Kumar (832817)   +7 more
core   +2 more sources

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Patient characteristics (mPAP – mean pulmonary arterial pressure, PVR – pulmonary vascular resistance, CO – cardiac output, CI – cardiac index).

, 2012
Patient characteristics (mPAP – mean pulmonary arterial pressure, PVR – pulmonary vascular resistance, CO – cardiac output, CI – cardiac index).
Diana Zabini (142555), Elvira Stacher (142562), Walter Klepetko (110147), Irene M. Lang (142567), Patrick Nierlich (142573), Chandran Nagaraj (142558), Zoltán Bálint (142590), Horst Olschewski (142585), Akos Heinemann (142582), Andrea Olschewski (142595)   +9 more
core   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source