Results 41 to 50 of about 4,197,466 (259)

Glucagon‐Like Peptide‐1 Receptor Agonists in Multiple Sclerosis: A Topical Narrative Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The glucagon‐like peptide‐1 (GLP‐1) receptor agonists (RAs) are a relatively new class of drugs that were initially approved by the US Food and Drug Administration to improve glycemic control in patients with type 2 diabetes mellitus and, subsequently, weight reduction in patients with obesity.
Audrey Y. Chang, Farrah J. Mateen
wiley   +1 more source

Shunt resistance is associated with clinically important outcomes after the Norwood operationCentral MessagePerspective

JTCVS Open, 2022
Background: In single-ventricle physiology, focus on pulmonary vascular resistance neglects the resistance in the conduit supplying the pulmonary inflow. Methods: Conduit length and diameter, which can approximate conduit resistance, are available in the
Zachary A. Spigel, MD, MPH, Athar M. Qureshi, MD, Alyssa Kalustian, MD, Ziyad M. Binsalamah, MD, Michiaki Imamura, MD, PhD, Christopher A. Caldarone, MD   +5 more
doaj   +1 more source

The Development of Rheumatoid Arthritis–Specific Ambulatory Care–Sensitive Conditions: Results of a Consensus Process

Arthritis Care &Research, EarlyView.
Objective Ambulatory care–sensitive conditions (ACSCs) serve as indicators of access, quality, and performance of the health system. This study aimed to determine rheumatoid arthritis (RA)‐specific ACSCs for use in the evaluation of care system access and quality.
Kara Irwin, Candace H. Feldman, Claire E. H. Barber, Gabriel Fabreau, Jake Jennings, Scott Patten, Cheryl Barnabe, Inflammatory Arthritis‐Specific ACSC Consensus Process Working Group   +7 more
wiley   +1 more source

Beyond Visual Scoring: Computational Computed Tomography Analysis for High‐Resolution Computed Tomography–Based Quantification of Interstitial Lung Disease in Inflammatory Rheumatic Disease

Arthritis Care &Research, EarlyView.
Interstitial lung disease (ILD) is a significant cause of morbidity and mortality in patients with inflammatory rheumatic disorders (IRDs). High‐resolution computed tomography (HRCT) is widely considered the gold standard for the noninvasive assessment of ILD; however, its interpretation is constrained by substantial interobserver variability and the ...
Alexander Pfeil, Tobias Hoffmann, Ulf Teichgräber, Diane Renz, Denise Beckmann, Gunter Wolf, Nicole Schadewaldt, Bianca Lassen‐Schmidt   +7 more
wiley   +1 more source

Modelling the pulmonary vasculature

, 2009
Mathematical models in physiology aim to describe an observable structure or function (or how they relate) using mathematical equations. A computational model solves a system of equations to predict an output, usually as some controlling parameters are ...
Tawhai, Merryn, Burrowes, Kelly
core   +1 more source

Poisson's Ratio‐Driven Control of Myogenic Differentiation and Maturation in Auxetic Metamaterials under Dynamic Mechanical Stimulation

Advanced Functional Materials, EarlyView.
This study explored how innovative “auxetic” scaffolds, which expand when stretched, influence skeletal muscle development. Researchers cultured muscle cells on different scaffold designs and applied repeated stretching over 10 days. They found that scaffold geometry affected muscle cell differentiation and fiber formation.
Maria Kalogeropoulou, Prabhdeep Kaur, Monica Boffito, Pierpaolo Fucile, Gianluca Ciardelli, Lorenzo Moroni   +5 more
wiley   +1 more source

Versican accumulates in vascular lesions in pulmonary arterial hypertension

, 2016
Pulmonary arterial hypertension (PAH) is a lethal condition for which there is no effective curative pharmacotherapy. PAH is characterized by vasoconstriction, wall thickening of pulmonary arteries, and increased vascular resistance.
Chan, Christina K., Inger Eriksson, Cao, Xiaofang, Ya‐Ting Chang, Tran-Lundmark, Karin,, Xiaofang Cao, Andersson-Sjöland, Annika, Kjellen, Lena,, Kjellén, Lena, Andersson-Sjoland, Annika,, Pamela Y. Johnson, Johansson, Staffan,, Gunilla Westergren‐Thorsson, Johnson, Pamela Y., Ulf Hedin, Karin Tran‐Lundmark, Cao, Xiaofang,, Wight, Thomas N., Westergren-Thorsson, Gunilla, Westöö, Christian, Tran-Lundmark, Karin, Johansson, Staffan, Lena Kjellén, Christian Westöö, Eriksson, Inger,, Annika Andersson‐Sjöland, Christina K. Chan, Thomas N. Wight, Hedin, Ulf,, Wight, Thomas N.,, Christian Norvik, Chang, Ya-Ting,, Chan, Christina K.,, Johnson, Pamela Y.,, Norvik, Christian, Hedin, Ulf, Chang, Ya Ting, Westoo, Christian,, Norvik, Christian,, Westergren-Thorsson, Gunilla,, Staffan Johansson, Eriksson, Inger, Eriksson, I, Andersson-Sjoland, A, Johansson, S, Lund University., Westergren-Thorsson, G, Westoo, C, Cao, X, Chan, CK, Chang, Y-T, Chang, Ya Ting,, Johnson, PY, Norvik, C   +53 more
core   +1 more source

Hemocompatible Glycogen‐Tissue Plasminogen Activator Complexes for Enhanced Blood Clot Dissolution

Advanced Healthcare Materials, EarlyView.
Glycogen–heparin‐cRGD nanoparticles enable targeted delivery of tissue plasminogen activator (tPA) to thrombi through activated platelet recognition. The hemocompatible hybrids minimize interactions with blood and immune cells while retaining enzymatic biodegradability.
Nadiia Davydiuk, Vaidehi Londhe, Susanne Boye, Martin Müller, Carsten Werner, Manfred F. Maitz, Quinn A. Besford   +6 more
wiley   +1 more source

Effects of increased intracranial pressure on pulmonary vascular resistance of fetal and neonatal goats

, 1977
The effects of increased intracranial pressure on the pulmonary circulation were investigated in fetal and neonatal goats. Pulmonary vascular resistance and systemic arterial pressure increased with elevation of intracranial pressure in neonatal animals.
S. Cassin, J. R. Hessler
core   +1 more source

Mechanoactive Biomaterials for Cell–Matrix Mechanotransduction

Advanced Materials, EarlyView.
The graphical abstract shows how individual triggers (force, light, or temperature) and combined optothermal or receptor‐targeted actuation induce material responses at the tissue, cellular, and receptor scales. Their spatial (global or focused) and temporal (continuous or cyclic) modulation determines the resulting mechanical output.
Yi‐Tung Lu, Alison E. John, Marc A. Fernández‐Yagüe   +2 more
wiley   +1 more source