Results 1 to 10 of about 123,379 (209)

PUMA amplifies necroptosis signaling by activating cytosolic DNA sensors [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2018
Necroptosis, a form of regulated necrotic cell death, is governed by RIP1/RIP3-mediated activation of MLKL. However, the signaling process leading to necroptotic death remains to be elucidated.
Dongshi Chen, Jingshan Tong, Jian Yu
exaly   +3 more sources

The multi-targeted kinase inhibitor sunitinib induces apoptosis in colon cancer cells via PUMA. [PDF]

PLoS ONE, 2012
Constitutive activation of pro-survival kinases has become a promising target of small molecules with an increasing interest in developing multi-targeted agents.
Jing Sun, Quanhong Sun, Matthew F Brown, Crissy Dudgeon, Julie Chandler, Xiang Xu, Yongqian Shu, Lin Zhang, Jian Yu   +8 more
doaj   +6 more sources

Puma, noxa, p53, and p63 differentially mediate stress pathway induced apoptosis

Cell Death and Disease, 2021
Cellular stress can lead to several human disease pathologies due to aberrant cell death. The p53 family (tp53, tp63, and tp73) and downstream transcriptional apoptotic target genes (PUMA/BBC3 and NOXA/PMAIP1) have been implicated as mediators of stress ...
Zhang Li, Shaida A Andrabi, John M Parant   +2 more
exaly   +2 more sources

PUMA reduces FASN ubiquitination to promote lipid accumulation and tumor progression in human clear cell renal cell carcinoma [PDF]

Cell Death and Disease
While the p53 upregulated modulator of apoptosis (PUMA) is traditionally recognized for promoting cell apoptosis and enhancing chemotherapy efficacy in various cancers, its role in clear cell renal cell carcinoma (ccRCC) remains unclear due to ccRCC’s ...
Qianqian Luo, Qi Wang, Jian Shi, Qingyang LV, Zirui Dong, Wen Li, Yaru Xia, Jingchong Liu, Hongmei Yang   +8 more
doaj   +2 more sources

Cardioprotective effect of Ginger in a rat model of myocardial damage and its possible intervention in PERK-ATF4-CHOP-PUMA apoptotic pathway [PDF]

The Ukrainian Biochemical Journal, 2023
For today the exact mechanisms of myocardial infarction and ischemia/reperfusion injury are still not fully understood. ER stress and integrated stress response pathways are thought to play an essential role in myocardial damage. This includes activation
M. M. Mohammed, N. A. A. Osman, F. M. Mourad , M. F. Abedelbaky   +3 more
doaj   +1 more source

PUMA, antiProton unstable matter annihilation

The European Physical Journal A, 2022
AbstractPUMA, antiProton Unstable Matter Annihilation, is a nuclear-physics experiment at CERN aiming at probing the surface properties of stable and rare isotopes by use of low-energy antiprotons. Low-energy antiprotons offer a very unique sensitivity to the neutron and proton densities at the annihilation site, i.e. in the tail of the nuclear density.
Aumann, T., Bartmann, W., Boine-Frankenheim, O., Bouvard, A., Broche, A., Butin, F., Calvet, D., Carbonell, J., Chiggiato, P., De Gersem, H., De Oliveira, R., Dobers, T., Ehm, F., Somoza, J. Ferreira, Fischer, J., Fraser, M., Friedrich, E., Frotscher, A., Gomez-Ramos, M., Grenard, J-L., Hobl, A., Hupin, G., Husson, A., Indelicato, P., Johnston, K., Klink, C., Kubota, Y., Lazauskas, R., Malbrunot-Ettenauer, S., Marsic, N., Mueller, W.FO., Naimi, S., Nakatsuka, N., Necca, R., Neidherr, D., Neyens, G., Obertelli, A., Ono, Y., Pasinelli, S., Paul, N., Pollacco, E.C., Rossi, D., Scheit, H., Schlaich, M., Schmidt, A., Schweikhard, L., Seki, R., Sels, S., Siesling, E., Uesaka, T., Vilen, M., Wada, M., Wienholtz, F., Wycech, S., Zacarias, S.   +54 more
openaire   +2 more sources

PUMA mediated afatinib-induced apoptosis in glioma cells

Archives of Medical Science, 2021
Introduction Afatinib exhibits a tumor-inhibiting effect in different cancers by inducing apoptosis; however, its pro-apoptosis role in glioma cells is still not fully understood. Material and methods In the current study, two glioma cell lines (U373-MG
Rongzhong Lu, Xinyue Sun, Yaping Ma, Rong Wang   +3 more
doaj   +1 more source

Hematology of mountain lions (Puma concolor) in the Sierra Nevada, California, USA: effect of sex, season, or location?

California Fish and Wildlife Journal, 2020
There is a paucity of published hematological data for wild, free-ranging mountain lions (Puma concolor). We collected such information from mountain lions occurring at mid-elevations to increase available baseline information. We captured and sampled
Vernon C. Bleich, Becky M. Pierce, Holly B. Ernest, Jeffrey T. Villepique   +3 more
doaj   +1 more source

Genomic ancestry of the American puma (Puma concolor) [PDF]

Journal of Heredity, 2000
Puma concolor, a large American cat species, occupies the most extensive range of any New World terrestrial mammal, spanning 110 degrees of latitude from the Canadian Yukon to the Straits of Magellan. Until the recent Holocene, pumas coexisted with a diverse array of carnivores including the American lion (Panthera atrox), the North American cheetah ...
Culver, Melanie, Johnson, Warren E., Pecon-Slattery, Jill, O'Brien, Stephen J.   +3 more
openaire   +2 more sources

Puma (Puma concolor) epididymal sperm morphometry

Asian Journal of Andrology, 2016
The Andean puma (Puma concolor) has not been widely studied, particularly in reference to its semen characteristics. The aim of the present study was to define the morphometry of puma sperm heads and classify their subpopulations by cluster analysis. Samples were recovered postmortem from two epididymides from one animal and prepared for morphological ...
Hernán Cucho, Virgilio Alarcón, César Ordóñez, Enrique Ampuero, Aydee Meza, Carles Soler   +5 more
openaire   +3 more sources