Results 31 to 40 of about 1,805 (151)

Exploiting Ferroelectric and Spintronic Dynamics for Neural Network Computation

Advanced Intelligent Systems, EarlyView.
Ferroelectric and spintronic devices, relying on the control of polarization and magnetization, offer intrinsically fast, durable, energy‐efficient, and low‐latency building blocks for analog in‐memory computing. The hysteretic dynamics of an order parameter are leveraged to provide nonvolatile, multistate memory and nonlinear switching. Brain‐inspired
Dashiell Harrison, Kevin Nadaud, Josquin Harrison, Guillaume F. Nataf, Laura Bégon‐Lours   +4 more
wiley   +1 more source

Uncoupling of PUMA Expression and Apoptosis Contributes to Functional Heterogeneity in Renal Cell Carcinoma — Prognostic and Translational Implications

Translational Oncology, 2015
Renal cell carcinoma (RCC) is characterized by a profound disruption of proapoptotic signaling networks leading to chemo- and radioresistance. A key mediator of DNA damage-induced apoptosis is the BH3-only protein PUMA.
Xiaoguang Zhou, Jielin Li, Christina Marx, Yanis Tolstov, Geraldine Rauch, Esther Herpel, Stephan Macher-Goeppinger, Wilfried Roth, Carsten Grüllich, Sascha Pahernik, Markus Hohenfellner, Stefan Duensing   +11 more
doaj   +1 more source

Energy‐Aware Perturbation Optimization for Memristor‐Array Convolutional Neural Networks

Advanced Intelligent Systems, EarlyView.
Memristor‐array inference becomes more energy efficient when layer inputs are reshaped before computation. Sinusoidal perturbation encoding with dual‐threshold screening reduces active voltage pulses and contracts ADC input‐current ranges, jointly lowering crossbar and peripheral energy while preserving accuracy across hardware MNIST validation, deep ...
Ao Xu, Lun Lu, Youpeng Wu, Yao Guo, Yi Li, Yinan Wang, Qingjiang Li   +6 more
wiley   +1 more source

The multi-targeted kinase inhibitor sunitinib induces apoptosis in colon cancer cells via PUMA.

PLoS ONE, 2012
Constitutive activation of pro-survival kinases has become a promising target of small molecules with an increasing interest in developing multi-targeted agents.
Jing Sun, Quanhong Sun, Matthew F Brown, Crissy Dudgeon, Julie Chandler, Xiang Xu, Yongqian Shu, Lin Zhang, Jian Yu   +8 more
doaj   +1 more source

Segmental composition and nerve distribution of the brachial plexus in Galictis cuja

The Anatomical Record, EarlyView.
Abstract Galictis cuja is a neotropical mustelid with terrestrial locomotor habits, yet the anatomy of its brachial plexus has remained undescribed. This study characterizes the origin, organization, and distribution of the brachial plexus nerves in 15 adult specimens (30 antimeres).
Natan da Cruz de Carvalho, Thais Mattos Estruc, Ingrid Bete Palmeira, Julia Fagundes Franco, Emillin Reis Bermudez, Paulo de Souza‐Junior, Marcelo Abidu‐Figueiredo   +6 more
wiley   +1 more source

Investigation of Stray‐Light Patterns in the eROSITA X‐Ray Cameras

Astronomische Nachrichten, EarlyView.
ABSTRACT eROSITA (extended ROentgen Survey with an Imaging Telescope Array) is the soft X‐ray instrument aboard the Spectrum‐Roentgen‐Gamma (SRG) mission, developed under the responsibility of the Max Planck Institute for Extraterrestrial Physics (MPE).
Veronika Stieglitz, Peter Friedrich, Susanne Friedrich, Konrad Dennerl, Michael Freyberg   +4 more
wiley   +1 more source

Platycodin D induces apoptosis through JNK1/AP-1/PUMA pathway in non-small cell lung cancer cells: A new mechanism for an old compound

Frontiers in Pharmacology, 2022
Platycodin D, a triterpenoid monomer, has been shown to possess an anti-tumor effect on various types of cancer. Although Platycodin D has been reported to suppress tumorigenesis, the detailed underlying mechanism remains elusive.
Shuntai Chen, Shuntai Chen, Shuntai Chen, Qing Wang, Qing Wang, Sarah Ming, Honggang Zheng, Baojin Hua, Hsin-Sheng Yang, Hsin-Sheng Yang   +9 more
doaj   +1 more source

Beyond the label: Rethinking off‐label drug use in paediatrics. Towards a scientifically grounded and safer future for paediatric pharmacotherapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Despite regulatory progress being made in the past two decades, off‐label drug use in paediatrics remains pervasive, with prevalence estimated between 3% and 97% of prescriptions across different clinical settings. Off‐label use—defined as prescribing outside the conditions described in the Summary of Product Characteristics (SmPC)—is often ...
Tjitske M. van der Zanden, Miriam G. Mooij, Matthijs de Hoog, Saskia N. de Wildt   +3 more
wiley   +1 more source

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

BMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu, Xuejian Wang, Wenyan Jiang, Wan Hairul Anuar Kamaruddin, Chunyan Fang, Pengfei Zhang   +5 more
wiley   +1 more source

Fas/FasL mediates NF-κBp65/PUMA-modulated hepatocytes apoptosis via autophagy to drive liver fibrosis

Cell Death and Disease, 2021
Fas/Fas ligand (FasL)-mediated cell apoptosis involves a variety of physiological and pathological processes including chronic hepatic diseases, and hepatocytes apoptosis contributes to the development of liver fibrosis following various causes. However,
Siwei Tan, Xianzhi Liu, Lingjun Chen, Xiaoqin Wu, Li Tao, Xuemei Pan, Shuyan Tan, Huiling Liu, Jie Jiang, Bin Wu   +9 more
doaj   +1 more source