Results 31 to 40 of about 43,136 (308)
Global Ecology and Conservation, 2022 Range-wide status assessments of wildlife are critical to effective species conservation and management. Reliability of these assessments is contingent on having accurate and precise demographic estimates for local populations, but for large carnivores ...
Sean M. Murphy +3 more
doaj +1 more source
The Oncologist, EarlyView., 2021 Abstract Background LIBRETTO‐001 is an ongoing, global, open‐label, phase I/II study of selpercatinib in patients with advanced or metastatic solid tumors. We report interim patient‐reported outcomes in patients with RET fusion–positive non‐small cell lung cancer (NSCLC).
Anna Minchom +11 more
wiley +1 more source
The ecological role of native and introduced species in the diet of the puma Puma concolor in southern Patagonia [PDF]
, 2012 There is evidence for the ecological extinction of the native prey of the puma Puma concolor in north-western Argentine Patagonia. In this study we examine whether this is also the case in southern Patagonia. From 2004 to 2007 we examined the puma's diet
Travaini, Alejandro +9 more
core +1 more source
The Oncologist, EarlyView., 2021 Abstract Background Medullary thyroid cancer (MTC) standard of care includes multikinase inhibitors (MKIs), which can exacerbate disease‐related diarrhea, primarily because of non‐RET kinase inhibition. We report diarrhea and other patient‐reported outcomes (PROs) with selpercatinib, a highly selective RET inhibitor, among patients with RET‐mutant MTC ...
Lori J. Wirth +10 more
wiley +1 more source
The p53-target gene puma drives neutrophil-mediated protection against lethal bacterial sepsis. [PDF]
PLoS Pathogens, 2010 Disruption of p53/Puma-mediated apoptosis protects against lethality due to DNA damage. Here we demonstrate the unexpected requirement of the pro-apoptotic p53-target gene Puma to mount a successful innate immune response to bacterial sepsis.
Sean P Garrison +7 more
doaj +1 more source
Survival and Mortality of Pumas (Puma concolor) in a Fragmented, Urbanizing Landscape [PDF]
Proceedings of the Vertebrate Pest Conference, 2015 Wide-ranging large carnivores pose myriad challenges for conservation, especially in highly fragmented landscapes. Over a 13-year period, we combined monitoring of radio collared pumas (Puma concolor) with complementary multi-generational genetic analyses to inform puma conservation in southern California, USA.
Vickers, T. Winston +9 more
openaire +8 more sources
Chronic inflammation evoked by pathogenic stimulus during carcinogenesis
4 open, 2019 A pathogenic (biological or chemical) stimulus is the earliest information received by a cell that can result in the disruption of homeostasis with consequent development of disease.
Brücher Björn L.D.M., Jamall Ijaz S.
doaj +1 more source
Frontiers in MicrobiologyEssential oils (EOs) have long been studied for their antimicrobial properties, yet most investigations rely on simplistic models, limited strain panels, and anecdotal interpretations—failing to meet the standards expected of modern anti-infective agents.
Malwina Brożyna +6 more
doaj +1 more source
Mammalogy Notes, 2017 El 19 de marzo de 2016 a las 14h50 observamos un Puma en un parche de bosque pequeño (5,2 ha) en el distrito de Santiago, San Ramón, Provincia de Alajuela, Costa Rica (10,057109° N, -84,492416° W; Figura 2).
Brayan Heiner Morera-Chacón +1 more
doaj +1 more source
PLoS ONE, 2013 HER2 is overexpressed in 15-20% of breast cancers. HER2 overexpression is known to reduce apoptosis but the underlying mechanisms for this association remain unclear.
Richard L Carpenter +3 more
doaj +1 more source