Results 51 to 60 of about 43,136 (308)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Puma strikes Bax [PDF]

Journal of Cell Biology, 2009
The commitment to programmed cell death via apoptosis is largely made upon activation of the proapoptotic mitochondrial proteins Bax or Bak. In this issue, Gallenne et al. (Gallenne, C., F. Gautier, L. Oliver, E. Hervouet, B. Noël, J.A. Hickman, O. Geneste, P.-F. Cartron, F.M. Vallette, S. Manon, and P. Juin. 2009. J. Cell Biol.
openaire   +2 more sources

PUMA HL7 Engine

, 2013
The PUMA Repository is a collection of Pascal units supporting medical informatics. It contains reusable source code for a wide field of health-care application development. The code includes converting functions for units of measurement (Unit Converter)
Dietrich, Johannes W., Dietrich, Johannes W. (5476061)   +1 more
core   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Preclinical and clinical evaluation through serial colonoscopic evaluation of neratinib‐induced diarrhea in HER2‐positive breast cancer—A pilot study

Physiological Reports
The irreversible pan‐HER tyrosine kinase inhibitor neratinib is approved for patients with HER2‐positive, early‐stage and metastatic breast cancer (BC). Neratinib‐associated diarrhea is the most common reason for early discontinuation.
Joanne Bowen, Sofia Braga, Valeria Dal Zotto, John Finnie, Daniel DiPrimeo, Blaire Cooke, Georg F. Bischof, Alvin Wong, Jack A. Di Palma   +8 more
doaj   +1 more source

Uncoupling of PUMA Expression and Apoptosis Contributes to Functional Heterogeneity in Renal Cell Carcinoma — Prognostic and Translational Implications

Translational Oncology, 2015
Renal cell carcinoma (RCC) is characterized by a profound disruption of proapoptotic signaling networks leading to chemo- and radioresistance. A key mediator of DNA damage-induced apoptosis is the BH3-only protein PUMA.
Xiaoguang Zhou, Jielin Li, Christina Marx, Yanis Tolstov, Geraldine Rauch, Esther Herpel, Stephan Macher-Goeppinger, Wilfried Roth, Carsten Grüllich, Sascha Pahernik, Markus Hohenfellner, Stefan Duensing   +11 more
doaj   +1 more source

PUMA Survey 5.2. Insights in societal changes in Austria

, 2019
Full edition for scientific use. PUMA Surveys consist of separate modules designed and prepared by different principle investigators. This PUMA Survey consists of three modules: MODULE 1 "Non-Health Influences on Generic Health Ratings: Comparing the ...
PUMA
core   +1 more source

Chromosomal Instability Drives Glioblastoma Heterogeneity and Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Glioblastoma, the most aggressive and lethal form of brain cancer, is defined by profound genomic instability, with Chromosomal Instability (CIN) playing a central role in driving tumor progression, therapy resistance, and poor prognosis. CIN is characterized by numerical and structural alterations, is driven by mechanisms such as mitotic ...
Amarnath Pal, Milan Patra, Rianita Mondal, Shubhasis Haldar   +3 more
wiley   +1 more source

The multi-targeted kinase inhibitor sunitinib induces apoptosis in colon cancer cells via PUMA.

PLoS ONE, 2012
Constitutive activation of pro-survival kinases has become a promising target of small molecules with an increasing interest in developing multi-targeted agents.
Jing Sun, Quanhong Sun, Matthew F Brown, Crissy Dudgeon, Julie Chandler, Xiang Xu, Yongqian Shu, Lin Zhang, Jian Yu   +8 more
doaj   +1 more source

PUMA Survey 6.2. Insights in societal changes in Austria

, 2019
Full edition for scientific use. PUMA Surveys consist of separate modules designed and prepared by different principle investigators. This PUMA Survey consists of three modules: MODULE 1 "High performing doctors or cold-hearted bureaucrats?
PUMA
core   +1 more source