Results 41 to 50 of about 28,540 (263)
The multi-targeted kinase inhibitor sunitinib induces apoptosis in colon cancer cells via PUMA.
PLoS ONE, 2012 Constitutive activation of pro-survival kinases has become a promising target of small molecules with an increasing interest in developing multi-targeted agents.
Jing Sun +8 more
doaj +1 more source
FOS3D: A Fluorescence‐Enabled Toolkit for Characterizing a Three‐dimensional Osteosarcoma Model
Advanced Science, EarlyView.FOS3D describes fluorescent (F) osteosarcoma (OS) cells in a tri‐dimensional (3D) model. The study comprises three phases: development, where biofabrication parameters are tuned to achieve cytocompatibility and tumor‐specific mechanical properties in cell‐laden gelatin methacryloyl constructs; validation, where whole‐well fluorescence reading is ...
William Humble +9 more
wiley +1 more source
Exploiting Ferroelectric and Spintronic Dynamics for Neural Network Computation
Advanced Intelligent Systems, EarlyView.Ferroelectric and spintronic devices, relying on the control of polarization and magnetization, offer intrinsically fast, durable, energy‐efficient, and low‐latency building blocks for analog in‐memory computing. The hysteretic dynamics of an order parameter are leveraged to provide nonvolatile, multistate memory and nonlinear switching. Brain‐inspired
Dashiell Harrison +4 more
wiley +1 more source
Response of pumas (Puma concolor) to migration of their primary prey in Patagonia
PLOS ONE, 2017 Large-scale ungulate migrations result in changes in prey availability for top predators and, as a consequence, can alter predator behavior. Migration may include entire populations of prey species, but often prey populations exhibit partial migration with some individuals remaining resident and others migrating.
Maria L. Gelin +5 more
openaire +5 more sources
Energy‐Aware Perturbation Optimization for Memristor‐Array Convolutional Neural Networks
Advanced Intelligent Systems, EarlyView.Memristor‐array inference becomes more energy efficient when layer inputs are reshaped before computation. Sinusoidal perturbation encoding with dual‐threshold screening reduces active voltage pulses and contracts ADC input‐current ranges, jointly lowering crossbar and peripheral energy while preserving accuracy across hardware MNIST validation, deep ...
Ao Xu +6 more
wiley +1 more source
Pathogens, 2021 Neotropical wild felids (NWF) are obligate carnivore species present in Central and South America, and some are considered endangered due to constantly decreasing populations.
Manuel Uribe +6 more
doaj +1 more source
Segmental composition and nerve distribution of the brachial plexus in Galictis cuja
The Anatomical Record, EarlyView.Abstract Galictis cuja is a neotropical mustelid with terrestrial locomotor habits, yet the anatomy of its brachial plexus has remained undescribed. This study characterizes the origin, organization, and distribution of the brachial plexus nerves in 15 adult specimens (30 antimeres).
Natan da Cruz de Carvalho +6 more
wiley +1 more source
Cell Death and Disease, 2021 Fas/Fas ligand (FasL)-mediated cell apoptosis involves a variety of physiological and pathological processes including chronic hepatic diseases, and hepatocytes apoptosis contributes to the development of liver fibrosis following various causes. However,
Siwei Tan +9 more
doaj +1 more source
British Journal of Clinical Pharmacology, EarlyView.Abstract Despite regulatory progress being made in the past two decades, off‐label drug use in paediatrics remains pervasive, with prevalence estimated between 3% and 97% of prescriptions across different clinical settings. Off‐label use—defined as prescribing outside the conditions described in the Summary of Product Characteristics (SmPC)—is often ...
Tjitske M. van der Zanden +3 more
wiley +1 more source