Results 21 to 30 of about 1,805 (151)

iNOS/NO is required for IRF1 activation in response to liver ischemia-reperfusion in mice

Molecular Medicine, 2020
Background Ischemia and reperfusion (I/R) induces cytokines, and up-regulates inducible nitric oxide synthase (iNOS), interferon regulatory factor-1(IRF1) and p53 up-regulated modulator of apoptosis (PUMA), which contribute to cell death and tissue ...
Qiang Du, Jing Luo, Mu-Qing Yang, Quan Liu, Caroline Heres, Yi-He Yan, Donna Stolz, David A. Geller   +7 more
doaj   +1 more source

Preclinical and clinical evaluation through serial colonoscopic evaluation of neratinib‐induced diarrhea in HER2‐positive breast cancer—A pilot study

Physiological Reports
The irreversible pan‐HER tyrosine kinase inhibitor neratinib is approved for patients with HER2‐positive, early‐stage and metastatic breast cancer (BC). Neratinib‐associated diarrhea is the most common reason for early discontinuation.
Joanne Bowen, Sofia Braga, Valeria Dal Zotto, John Finnie, Daniel DiPrimeo, Blaire Cooke, Georg F. Bischof, Alvin Wong, Jack A. Di Palma   +8 more
doaj   +1 more source

Dietary patterns of a versatile large carnivore, the puma (Puma concolor)

Ecology and Evolution, 2022
Large carnivores play critical roles in terrestrial ecosystems but have suffered dramatic range contractions over the past two centuries. Developing an accurate understanding of large carnivore diets is an important first step towards an improved ...
Harshad Karandikar, Mitchell W. Serota, Wilson C. Sherman, Jennifer R. Green, Guadalupe Verta, Claire Kremen, Arthur D. Middleton   +6 more
doaj   +1 more source

Review of puma density estimates reveals sources of bias and variation, and the need for standardization

Global Ecology and Conservation, 2022
Range-wide status assessments of wildlife are critical to effective species conservation and management. Reliability of these assessments is contingent on having accurate and precise demographic estimates for local populations, but for large carnivores ...
Sean M. Murphy, Richard A. Beausoleil, Haley Stewart, John J. Cox   +3 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Proliferative and Survival Effects of PUMA Promote Angiogenesis

Cell Reports, 2012
The p53 upregulated modulator of apoptosis (PUMA) is known as an essential apoptosis inducer. Here, we report the seemingly paradoxical finding that PUMA is a proangiogenic factor critically required for the proliferation and survival of vascular and ...
Fan Zhang, Yang Li, Zhongshu Tang, Anil Kumar, Chunsik Lee, Liping Zhang, Chaoyong Zhu, Anne Klotzsche-von Ameln, Bin Wang, Zhiqin Gao, Shizhuang Zhang, Harald F. Langer, Xu Hou, Lasse Jensen, Wenxin Ma, Wai Wong, Triantafyllos Chavakis, Yizhi Liu, Yihai Cao, Xuri Li   +19 more
doaj   +1 more source

Autoimmune Comorbidities as Modifiers of Phenotypic Heterogeneity in Facioscapulohumeral Dystrophy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral dystrophy type 1 (FSHD1) shows clinical heterogeneity that is only partly explained by D4Z4 repeat unit (RU) size. Although immune and inflammatory mechanisms may contribute to disease variability, the prevalence and clinical impact of autoimmune diseases in FSHD remain unclear.
Jonathan Pini, Giulia Tammam, Andra Ezaru, Manuela Gambella, Benoît Sanson, Luisa Villa, Michele Cavalli, Mihai‐Bogdan Ioncea, Angela Puma, Sabrina Sacconi   +9 more
wiley   +1 more source

RSF1‐Dependent PAR Turnover Promotes 53BP1 Liquid Condensate Formation at DNA Damage Sites

Advanced Science, EarlyView.
At sites of DNA damage, RSF1 recruits PARG to accelerate PAR turnover, triggering a switch from PAR‐driven condensates to 53BP1 condensates. This condensate transition enables p53‐dependent gene transcription and coordinates the DNA damage response.
Yungyeong Heo, Yonghyeon Kim, Nangyeong Hwang, Gwanho Sung, Sujin Jo, Yeonhu Lee, Ho‐Chul Kang, Jae‐Ho Lee, Yong Won Choi, Hyeseong Cho, Sunwoo Min   +10 more
wiley   +1 more source

Regulation of PUMA induced by mechanical stress in rat cardiomyocytes

Journal of Biomedical Science, 2012
Background PUMA (p53-up-regulated modulator of apoptosis), an apoptosis regulated gene, increased during endoplasmic reticulum stress. However, the expression of PUMA in cardiomyocytes under mechanical stress is little known.
Cheng Wen-Pin, Wu Gong-Jhe, Wang Bao-Wei, Shyu Kou-Gi   +3 more
doaj   +1 more source

Glucocorticoid Receptor Signaling in Myeloid Cells Orchestrates Inflammation Resolution and Muscle Repair

Advanced Science, EarlyView.
Glucocorticoids (GC) are widely used to reduce inflammation. We show that the glucocorticoid receptor in myeloid cells regulates macrophage cell cycle and genome integrity during muscle regeneration. We demonstrate that dexamethasone administration during the early inflammatory phase delays muscle repair by increasing macrophage proliferation ...
Sirine Souali‐Crespo, Joe G. Rizk, Emilia Calvano, Rajesh Sahu, Emina Colovic, Imane Chabba, Valentine Gilbart, Erwan Grandgirard, Bastien Morlet, Qingshuang Cai, Daniel Metzger, Delphine Duteil   +11 more
wiley   +1 more source