Results 21 to 30 of about 124,281 (312)
The Oncologist, EarlyView., 2021 Abstract Background Medullary thyroid cancer (MTC) standard of care includes multikinase inhibitors (MKIs), which can exacerbate disease‐related diarrhea, primarily because of non‐RET kinase inhibition. We report diarrhea and other patient‐reported outcomes (PROs) with selpercatinib, a highly selective RET inhibitor, among patients with RET‐mutant MTC ...
Lori J. Wirth +10 more
wiley +1 more source
The p53-target gene puma drives neutrophil-mediated protection against lethal bacterial sepsis. [PDF]
PLoS Pathogens, 2010 Disruption of p53/Puma-mediated apoptosis protects against lethality due to DNA damage. Here we demonstrate the unexpected requirement of the pro-apoptotic p53-target gene Puma to mount a successful innate immune response to bacterial sepsis.
Sean P Garrison +7 more
doaj +1 more source
Chronic inflammation evoked by pathogenic stimulus during carcinogenesis
4 open, 2019 A pathogenic (biological or chemical) stimulus is the earliest information received by a cell that can result in the disruption of homeostasis with consequent development of disease.
Brücher Björn L.D.M., Jamall Ijaz S.
doaj +1 more source
Pathogens, 2021 Neotropical wild felids (NWF) are obligate carnivore species present in Central and South America, and some are considered endangered due to constantly decreasing populations.
Manuel Uribe +6 more
doaj +1 more source
Mammalogy Notes, 2017 El 19 de marzo de 2016 a las 14h50 observamos un Puma en un parche de bosque pequeño (5,2 ha) en el distrito de Santiago, San Ramón, Provincia de Alajuela, Costa Rica (10,057109° N, -84,492416° W; Figura 2).
Brayan Heiner Morera-Chacón +1 more
doaj +1 more source
Journal of Cell Biology, 2009 The commitment to programmed cell death via apoptosis is largely made upon activation of the proapoptotic mitochondrial proteins Bax or Bak. In this issue, Gallenne et al. (Gallenne, C., F. Gautier, L. Oliver, E. Hervouet, B. Noël, J.A. Hickman, O. Geneste, P.-F. Cartron, F.M. Vallette, S. Manon, and P. Juin. 2009. J. Cell Biol.
openaire +2 more sources
Frontiers in MicrobiologyEssential oils (EOs) have long been studied for their antimicrobial properties, yet most investigations rely on simplistic models, limited strain panels, and anecdotal interpretations—failing to meet the standards expected of modern anti-infective agents.
Malwina Brożyna +6 more
doaj +1 more source
PLoS ONE, 2013 HER2 is overexpressed in 15-20% of breast cancers. HER2 overexpression is known to reduce apoptosis but the underlying mechanisms for this association remain unclear.
Richard L Carpenter +3 more
doaj +1 more source
E2F-1 induces melanoma cell apoptosis via PUMA up-regulation and Bax translocation
BMC Cancer, 2007 Background PUMA is a pro-apoptotic Bcl-2 family member that has been shown to be involved in apoptosis in many cell types. We sought to ascertain whether induction of PUMA plays a crucial role in E2F-1-induced apoptosis in melanoma cells.
Zhou H Sam +5 more
doaj +1 more source
Proliferative and Survival Effects of PUMA Promote Angiogenesis
Cell Reports, 2012 The p53 upregulated modulator of apoptosis (PUMA) is known as an essential apoptosis inducer. Here, we report the seemingly paradoxical finding that PUMA is a proangiogenic factor critically required for the proliferation and survival of vascular and ...
Fan Zhang +19 more
doaj +1 more source