Results 11 to 20 of about 1,724 (70)

Puma, noxa, p53, and p63 differentially mediate stress pathway induced apoptosis

Cell Death and Disease, 2021
Cellular stress can lead to several human disease pathologies due to aberrant cell death. The p53 family (tp53, tp63, and tp73) and downstream transcriptional apoptotic target genes (PUMA/BBC3 and NOXA/PMAIP1) have been implicated as mediators of stress ...
Jun Wang, Holly R. Thomas, Zhang Li, Nan Cher (Florence) Yeo, Hannah E. Scott, Nghi Dang, Mohammed Iqbal Hossain, Shaida A. Andrabi, John M. Parant   +8 more
doaj   +1 more source

The p53-target gene puma drives neutrophil-mediated protection against lethal bacterial sepsis. [PDF]

PLoS Pathogens, 2010
Disruption of p53/Puma-mediated apoptosis protects against lethality due to DNA damage. Here we demonstrate the unexpected requirement of the pro-apoptotic p53-target gene Puma to mount a successful innate immune response to bacterial sepsis.
Sean P Garrison, Justin A Thornton, Hans Häcker, Richard Webby, Jerold E Rehg, Evan Parganas, Gerard P Zambetti, Elaine I Tuomanen   +7 more
doaj   +1 more source

Chronic inflammation evoked by pathogenic stimulus during carcinogenesis

4 open, 2019
A pathogenic (biological or chemical) stimulus is the earliest information received by a cell that can result in the disruption of homeostasis with consequent development of disease.
Brücher Björn L.D.M., Jamall Ijaz S.
doaj   +1 more source

Presencia suburbana de Puma concolor (Carnivora: Felidae) en el cantón de San Ramón, Alajuela, Costa Rica

Mammalogy Notes, 2017
El 19 de marzo de 2016 a las 14h50 observamos un Puma en un parche de bosque pequeño (5,2 ha) en el distrito de Santiago, San Ramón, Provincia de Alajuela, Costa Rica (10,057109° N, -84,492416° W; Figura 2).
Brayan Heiner Morera-Chacón, Yaina Ruiz-Chaves   +1 more
doaj   +1 more source

HER2 phosphorylates and destabilizes pro-apoptotic PUMA, leading to antagonized apoptosis in cancer cells.

PLoS ONE, 2013
HER2 is overexpressed in 15-20% of breast cancers. HER2 overexpression is known to reduce apoptosis but the underlying mechanisms for this association remain unclear.
Richard L Carpenter, Woody Han, Ivy Paw, Hui-Wen Lo   +3 more
doaj   +1 more source

Establishing essential oil stewardship through the case of rosemary and thyme oils against Staphylococcus aureus

Frontiers in Microbiology
Essential oils (EOs) have long been studied for their antimicrobial properties, yet most investigations rely on simplistic models, limited strain panels, and anecdotal interpretations—failing to meet the standards expected of modern anti-infective agents.
Malwina Brożyna, Zuzanna Stępnicka, Zuzanna Stępnicka, Katarzyna Kapczyńska, Bartłomiej Dudek, Adam Matkowski, Adam Junka   +6 more
doaj   +1 more source

Two Ways of Suspending Object Agreement in Puma: Between Incorporation, Antipassivization, and Optional Agreement

Himalayan Linguistics, 2007
Although Kiranti languages generally show verb agreement with both arguments of a transitive verb, object agreement can also be suspended, resulting in the intransitive inflection of lexically transitive verbs.
Balthasar Bickel, Martin Gaenszle, Arjun Rai, Prem Dhoj Rai, Shree Kumar Rai, Vishnu S. Rai, Narayan P. Sharma (Gautam)   +6 more
doaj   +1 more source

E2F-1 induces melanoma cell apoptosis via PUMA up-regulation and Bax translocation

BMC Cancer, 2007
Background PUMA is a pro-apoptotic Bcl-2 family member that has been shown to be involved in apoptosis in many cell types. We sought to ascertain whether induction of PUMA plays a crucial role in E2F-1-induced apoptosis in melanoma cells.
Zhou H Sam, Gomez-Gutierrez Jorge G, Bowling Maria T, Dong Yanbin, Hao Hongying, McMasters Kelly M   +5 more
doaj   +1 more source

iNOS/NO is required for IRF1 activation in response to liver ischemia-reperfusion in mice

Molecular Medicine, 2020
Background Ischemia and reperfusion (I/R) induces cytokines, and up-regulates inducible nitric oxide synthase (iNOS), interferon regulatory factor-1(IRF1) and p53 up-regulated modulator of apoptosis (PUMA), which contribute to cell death and tissue ...
Qiang Du, Jing Luo, Mu-Qing Yang, Quan Liu, Caroline Heres, Yi-He Yan, Donna Stolz, David A. Geller   +7 more
doaj   +1 more source

Preclinical and clinical evaluation through serial colonoscopic evaluation of neratinib‐induced diarrhea in HER2‐positive breast cancer—A pilot study

Physiological Reports
The irreversible pan‐HER tyrosine kinase inhibitor neratinib is approved for patients with HER2‐positive, early‐stage and metastatic breast cancer (BC). Neratinib‐associated diarrhea is the most common reason for early discontinuation.
Joanne Bowen, Sofia Braga, Valeria Dal Zotto, John Finnie, Daniel DiPrimeo, Blaire Cooke, Georg F. Bischof, Alvin Wong, Jack A. Di Palma   +8 more
doaj   +1 more source