Results 11 to 20 of about 124,281 (312)
The multi-targeted kinase inhibitor sunitinib induces apoptosis in colon cancer cells via PUMA. [PDF]
PLoS ONE, 2012 Constitutive activation of pro-survival kinases has become a promising target of small molecules with an increasing interest in developing multi-targeted agents.
Jing Sun +8 more
doaj +6 more sources
Pharmacologically blocking p53-dependent apoptosis protects intestinal stem cells and mice from radiation. [PDF]
, 2015 Exposure to high levels of ionizing radiation (IR) leads to debilitating and dose-limiting gastrointestinal (GI) toxicity. Using three-dimensional mouse crypt culture, we demonstrated that p53 target PUMA mediates radiation-induced apoptosis via a cell ...
Cramer, Julie M +14 more
core +2 more sources
PUMA Cooperates with p21 to Regulate Mammary Epithelial Morphogenesis and Epithelial-To-Mesenchymal Transition. [PDF]
PLoS ONE, 2013 Lumen formation is essential for mammary morphogenesis and requires proliferative suppression and apoptotic clearance of the inner cells within developing acini.
Yanhong Zhang +3 more
doaj +1 more source
Jaguarundi (Puma yagouaroundi) predation by puma (Puma concolor) in the Brazilian Atlantic Forest [PDF]
Biota Neotropica, 2018 Abstract The jaguarundi (Puma yagouaroundi) is the second most widespread carnivore of the Americas, and considered a threatened species in Brazil. However, most of its ecology is unknown, and few information is available about species that may act as its predator.
Magioli, Marcelo +1 more
openaire +2 more sources
Factors Governing Risk of Cougar Attacks on Humans
Human-Wildlife Interactions, 2017 Since the 1980s wildlife managers in the United States and Canada have expressed increasing concern about the physical threat posed by cougars (Puma concolor) to humans.
David Mattson +2 more
doaj +1 more source
Carnivore-Livestock Conflicts in Chile: Evidence and Methods for Mitigation
Human-Wildlife Interactions, 2019 Human population growth and habitat loss have exacerbated human–wildlife conflicts worldwide. We explored trends in human–wildlife conflicts (HWCs) in Chile using scientific and official reports to identify areas and species with higher risk of conflicts
Valeska Rodriguez +4 more
doaj +1 more source
The role of apoptosis of enterocytes in inflammatory bowel diseases
Бюллетень сибирской медицины, 2018 Purpose. Study the topography of cells, expressing villin, p53, Bcl-2, and PUMA in the intestinal mucosa in the non-infectious colitis.Materials and methods.
N. Yu. Matveeva +4 more
doaj +1 more source
Puma, noxa, p53, and p63 differentially mediate stress pathway induced apoptosis
Cell Death and Disease, 2021 Cellular stress can lead to several human disease pathologies due to aberrant cell death. The p53 family (tp53, tp63, and tp73) and downstream transcriptional apoptotic target genes (PUMA/BBC3 and NOXA/PMAIP1) have been implicated as mediators of stress ...
Jun Wang +8 more
doaj +1 more source
Global Ecology and Conservation, 2022 Range-wide status assessments of wildlife are critical to effective species conservation and management. Reliability of these assessments is contingent on having accurate and precise demographic estimates for local populations, but for large carnivores ...
Sean M. Murphy +3 more
doaj +1 more source
The Oncologist, EarlyView., 2021 Abstract Background LIBRETTO‐001 is an ongoing, global, open‐label, phase I/II study of selpercatinib in patients with advanced or metastatic solid tumors. We report interim patient‐reported outcomes in patients with RET fusion–positive non‐small cell lung cancer (NSCLC).
Anna Minchom +11 more
wiley +1 more source