Results 201 to 210 of about 124,281 (312)

Five‐year outcomes of pembrolizumab versus chemotherapy in Chinese patients with non‐small‐cell lung cancer and programmed cell death ligand 1 tumor proportion score ≥1%: KEYNOTE‐042 China study

International Journal of Cancer, Volume 158, Issue 9, Page 2429-2439, 1 May 2026.
What's new? Global research has found that for people newly diagnosed with advanced non‐small cell lung cancer (NSCLC), the anti‐PD‐1 monoclonal antibody pembrolizumab on its own often leads to better results than traditional chemotherapy. The present report details long‐term findings of pembrolizumab therapy specifically among Chinese patients.
Yi‐Long Wu, Li Zhang, Yun Fan, JianYing Zhou, Li Zhang, Qing Zhou, Wei Li, ChengPing Hu, GongYan Chen, Xin Zhang, CaiCun Zhou, Carmen González Arenas, Zhenghong Chen, Wen Cheng Yu, Tony S. K. Mok   +14 more
wiley   +1 more source

Neuroprotection of IGF-1 in neonatal hypoxic-ischemic brain injury through downregulation of FoXO3a-PUMA pathway. [PDF]

Front Cell Neurosci
Tang Y, Zhong R, Liang J, Liu S, Liu W, Liu T, Yuan B, Jiao M, Yin H.   +8 more
europepmc   +1 more source

Taming Puma [PDF]

Nature Reviews Cancer, 2005
openaire   +1 more source

Moose indifferent to canopy loss from forest disturbance by bark beetles

The Journal of Wildlife Management, Volume 90, Issue 4, May 2026.
Moose showed strikingly similar patterns of habitat selection before and after widespread forest disturbance following an infestation of bark beetles. Our findings indicate that beetle‐kill does not appreciably alter habitat quality for moose and highlight the importance of riparian areas in sustaining moose as they contend with changing forests ...
Alexander B. May, Rebecca L. Levine, Lee Knox, Corey Class, Matthew J. Kauffman, Kevin L. Monteith   +5 more
wiley   +1 more source

ATGL sensitizes hepatocellular carcinoma cells to genotoxic drugs by modulating p53 acetylation/phosphorylation status. [PDF]

Cell Death Discov
Castelli S, De Cristofaro A, Desideri E, Salvi E, Ciccarone F, Ciriolo MR.   +5 more
europepmc   +1 more source

Dog attacks on wild desert tortoises: A risk model

The Journal of Wildlife Management, Volume 90, Issue 4, May 2026.
Domestic dogs attack and severely injure wild desert tortoises at the urban and ex‐urban interface with deserts. Severe trauma to tortoises increased 4 times to shell and limbs and 16.5 times to the gular horn over the decades between the 1970s and 2000s. Tortoises were at exponential risk of severe trauma when living within 12 km of settlements, towns,
Andrea S. Carlson, Kristin H. Berry, Jeremy S. Mack   +2 more
wiley   +1 more source

Novel antagonist APG-115 targets MDM2-p53 to induce p53-mediated apoptosis and radiosensitization in colorectal cancer. [PDF]

Clin Exp Med
Yi H, Han Y, Wang X, Li Q, Xiong L, Li S.   +5 more
europepmc   +1 more source

PUMA

, 2005
Fraedrich, K., Kirk, E., Lunkeit, F.
openaire   +1 more source

mRNA Lipid Nanoparticles for Cell Engineering in Vivo and in Vitro: Current Applications and Future Directions

MedComm, Volume 7, Issue 5, May 2026.
Schematic diagram of mRNA‐lipid nanoparticles (mRNA‐LNP) and its functional mechanisms, applications, and challenges in cell engineering. This figure details the structural composition of mRNA‐LNPs and the delivery strategy, highlighting three core challenges.
Lina Li, Menglan Wang, Xiuhan Ye, Zhiyan Liu, Yijing Duan, Xiaoming Chen, Yue Ouyang, Qibiao Wu, Mengjuan Sun, Tian Xie   +9 more
wiley   +1 more source

Exploring the impact of hAMSCs secretome on Panc1 cells via TNF-α/NF-κB (p50/p65)/Caspase 3 signaling pathways: An <i>in vitro</i> study. [PDF]

Biochem Biophys Rep
Khalafi A, Safari F.
europepmc   +1 more source