<i>In vitro</i> screening of compounds for targeting gastric cancer with Y220C p53 mutation: a molecule combining zinc chelation and a Michael acceptor drives <i>CDKN1</i> and <i>BBC3</i> expression to restore a p53-dependent cytotoxicity. [PDF]
Nannini S +20 more
europepmc +1 more source
ABSTRACT Aim Immunocompromised children (IC) were presumed to be at higher risk of SARS‐COV‐2 infection and severe COVID‐19, but population‐based evidence is limited. We assessed infection risk, COVID‐19 hospitalisation, and severe outcomes in IC compared with children with and without other high‐risk conditions.
Costanza Di Chiara +13 more
wiley +1 more source
Integrated transcriptomic analysis and experimental validation identify ACADL as a mitochondrial tumor suppressor via the FOXO3a/PUMA axis in lung adenocarcinoma. [PDF]
Wang Y, Ding Y.
europepmc +1 more source
Abstract Background Older breast cancer survivors are susceptible to cancer‐ and treatment‐related losses in physical function that can negatively affect daily living activities, mobility, and independence. Although physical activity can improve physical function, few studies have focused on older survivors or explored interrelationships between ...
Ashley L. Artese +24 more
wiley +1 more source
Unraveling the miR-144-3p/PUMA pathway: a novel regulator of FDX1-mediated cuproptosis in colorectal cancer. [PDF]
Jia G +11 more
europepmc +1 more source
This work presents a fully synthetic, 3D‐printed dynamic heart model with left‐side anatomy featuring sutured mitral valve chordae tendineae analogs, embedded actuators for physiologic wall contraction, and customized flexible pressure sensors for the left ventricle.
Alejandro Guillen Obando +7 more
wiley +1 more source
ABSTRACT Gut microbiota dysbiosis promotes colorectal cancer (CRC) tumorigenesis. A global fecal metagenomic analysis identified Gemella morbillorum as a key contributor to the CRC‐associated microbiota. Fluorescence in situ hybridization revealed that Gemella morbillorum is enriched in CRC tumor tissues compared to adjacent normal tissues.
Zhen Wang +8 more
wiley +1 more source
Digital Pathology-Based Comparison of PyRadiomics and HistomicsTK for Nuclei Classification in Melanoma Whole Slide Images. [PDF]
Finti A +5 more
europepmc +1 more source
La Espiritualidad: Transmitting Peruvian Culturo‐Spiritual Elements into Occidental Systemic Spaces
ABSTRACT This paper is a decolonising, Indigenous qualitative inquiry that integrates elements of critical autoethnography, narrative methods and conceptual analysis to explore how Peruvian Andean cosmology can inform contemporary systems thinking and family therapy practice.
Deisy Amorin‐Woods
wiley +1 more source

