Results 21 to 30 of about 123,460 (289)
The role of apoptosis of enterocytes in inflammatory bowel diseases
Бюллетень сибирской медицины, 2018 Purpose. Study the topography of cells, expressing villin, p53, Bcl-2, and PUMA in the intestinal mucosa in the non-infectious colitis.Materials and methods.
N. Yu. Matveeva +4 more
doaj +1 more source
Global Ecology and Conservation, 2022 Range-wide status assessments of wildlife are critical to effective species conservation and management. Reliability of these assessments is contingent on having accurate and precise demographic estimates for local populations, but for large carnivores ...
Sean M. Murphy +3 more
doaj +1 more source
The Oncologist, EarlyView., 2021 Abstract Background Medullary thyroid cancer (MTC) standard of care includes multikinase inhibitors (MKIs), which can exacerbate disease‐related diarrhea, primarily because of non‐RET kinase inhibition. We report diarrhea and other patient‐reported outcomes (PROs) with selpercatinib, a highly selective RET inhibitor, among patients with RET‐mutant MTC ...
Lori J. Wirth +10 more
wiley +1 more source
The p53-target gene puma drives neutrophil-mediated protection against lethal bacterial sepsis. [PDF]
PLoS Pathogens, 2010 Disruption of p53/Puma-mediated apoptosis protects against lethality due to DNA damage. Here we demonstrate the unexpected requirement of the pro-apoptotic p53-target gene Puma to mount a successful innate immune response to bacterial sepsis.
Sean P Garrison +7 more
doaj +1 more source
Chronic inflammation evoked by pathogenic stimulus during carcinogenesis
4 open, 2019 A pathogenic (biological or chemical) stimulus is the earliest information received by a cell that can result in the disruption of homeostasis with consequent development of disease.
Brücher Björn L.D.M., Jamall Ijaz S.
doaj +1 more source
Mammalogy Notes, 2017 El 19 de marzo de 2016 a las 14h50 observamos un Puma en un parche de bosque pequeño (5,2 ha) en el distrito de Santiago, San Ramón, Provincia de Alajuela, Costa Rica (10,057109° N, -84,492416° W; Figura 2).
Brayan Heiner Morera-Chacón +1 more
doaj +1 more source
Journal of Cell Biology, 2009 The commitment to programmed cell death via apoptosis is largely made upon activation of the proapoptotic mitochondrial proteins Bax or Bak. In this issue, Gallenne et al. (Gallenne, C., F. Gautier, L. Oliver, E. Hervouet, B. Noël, J.A. Hickman, O. Geneste, P.-F. Cartron, F.M. Vallette, S. Manon, and P. Juin. 2009. J. Cell Biol.
openaire +2 more sources
Frontiers in MicrobiologyEssential oils (EOs) have long been studied for their antimicrobial properties, yet most investigations rely on simplistic models, limited strain panels, and anecdotal interpretations—failing to meet the standards expected of modern anti-infective agents.
Malwina Brożyna +6 more
doaj +1 more source
E2F-1 induces melanoma cell apoptosis via PUMA up-regulation and Bax translocation
BMC Cancer, 2007 Background PUMA is a pro-apoptotic Bcl-2 family member that has been shown to be involved in apoptosis in many cell types. We sought to ascertain whether induction of PUMA plays a crucial role in E2F-1-induced apoptosis in melanoma cells.
Zhou H Sam +5 more
doaj +1 more source
iNOS/NO is required for IRF1 activation in response to liver ischemia-reperfusion in mice
Molecular Medicine, 2020 Background Ischemia and reperfusion (I/R) induces cytokines, and up-regulates inducible nitric oxide synthase (iNOS), interferon regulatory factor-1(IRF1) and p53 up-regulated modulator of apoptosis (PUMA), which contribute to cell death and tissue ...
Qiang Du +7 more
doaj +1 more source