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Physiological and Immune Functions of Punicalagin [PDF]

Nutrients, 2021
The aim of this publication is to compile a summary of the findings regarding punicalagin in various tissues described thus far in the literature, with an emphasis on the effect of this substance on immune reactions. Punicalagin (PUN) is an ellagitannin found in the peel of pomegranate (Punica granatum).
Pavel Horky, Adriana Kolesárová, Petr Slama   +2 more
exaly   +4 more sources

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Multifaceted Neuroprotective Role of Punicalagin: A Review

Neurochemical Research, 2023
Millions of people worldwide are currently afflicted with neurologic conditions like a seizure, depression, stress, Alzheimer's disease, Parkinson's disease, and Huntington's disease. However, the precise etiopathology of these diseases is still unknown. Substantial studies are being conducted to discover more treatments against these disorders because
Nazia, Siddiqui, Alimuddin, Saifi, Anurag, Chaudhary, Prabhash Nath, Tripathi, Ankit, Chaudhary, Alok, Sharma   +5 more
openaire   +2 more sources

One-Step Purification of Punicalagin by Preparative HPLC and Stability Study on Punicalagin

Separation Science and Technology, 2010
A novel, rapid, and high efficiency method to purify natural punicalagin by preparative HPLC is described. The optimum purification condition for punicalagin purification was 14% methanol in 0.1% trifluoroacetic acid solution as the mobile phase. The flow rate was 12 ml/min.
Ke Ding
exaly   +2 more sources

Punicalagin alleviates hepatotoxicity in rats challenged with cyclophosphamide

Environmental Toxicology and Pharmacology, 2016
This study investigated the possible hepatoprotection of punicalagin in rats received cyclophosphamide (20mg/kg/day, i.p., for 7 days). Punicalagin given at two doses, 15 and 30mg/kg/day, p.o., for 7 days, starting the same day of cyclophosphamide administration.
Hatem O Qutub, Amr Fouad
exaly   +3 more sources

Punicalagin is a neuraminidase inhibitor of influenza viruses

Journal of Medical Virology, 2020
AbstractInfluenza A virus (IAV) causes great morbidity and mortality worldwide every year. However, there are only a limited number of drugs clinically available against IAV infection. Further, emergence of drug‐resistant strains can render those drugs ineffective. Thus there is an unmet medical need to develop new anti‐influenza agents. In this study,
Ping, Li, Ruikun, Du, Zinuo, Chen, Yanyan, Wang, Peng, Zhan, Xinyong, Liu, Dongwei, Kang, Zhaoyu, Chen, Xiujuan, Zhao, Lin, Wang, Lijun, Rong, Qinghua, Cui   +11 more
openaire   +2 more sources

Punicalagin promotes human villous trophoblast differentiation

Placenta, 2016
Poor differentiation of trophoblasts is associated with placental dysfunction, predisposing women to multiple pregnancy disorders. Punicalagin, a prominent ellagitannin in pomegranate juice has been shown to exert anti-apoptosis and anti-oxidative effects in human trophoblasts. We hypothesized that punicalagin modulates trophoblast differentiation.
Baosheng, Chen, Mark S, Longtine, Maria Laura, Costa, D Michael, Nelson   +3 more
openaire   +2 more sources

In Vitro Studies on the Binding, Antioxidant, and Cytotoxic Actions of Punicalagin

Journal of Agricultural and Food Chemistry, 2007
The protective bioactivity of punicalagin, a high molecular weight polyphenol isolated from pomegranate fruit pith and carpellary membrane, against oxidative damages to lipids, amino acids constituting the proteins, and guanosine as a model for DNA has been investigated.
Anand P, Kulkarni, H S, Mahal, S, Kapoor, S M, Aradhya   +3 more
openaire   +2 more sources

Effects of Punicalagin and Punicalin on Carrageenan-Induced Inflammation in Rats

The American Journal of Chinese Medicine, 1999
Punicalagin and punicalin were isolated from the leaves of Terminalia catappa L. In this study, we evaluated the anti-inflammatory activity of punicalagin and punicalin carrageenan-induced hind paw edema in rats. After evaluation of the anti-inflammatory effects, the edema rates were increased by carrageenan administration and reduced by drug ...
C C, Lin, Y F, Hsu, T C, Lin
openaire   +2 more sources

Punicalagin inhibits neuroinflammation in LPS‐activated rat primary microglia

Molecular Nutrition and Food Research, 2014
ScopeIn this study, the effects of punicalagin on neuroinflammation in LPS‐activated microglia were investigated.Methods and resultsThe ability of punicalagin to reduce the production of TNF‐α, IL‐6 and prostaglandin E2 was measured in culture medium using enzyme immunoassay.
Ravikanth Velagapudi, Olumayokun A Olajide, Bernd L Fiebich   +2 more
exaly   +4 more sources

ChemInform Abstract: On the Structure of Punicalagin and Punicalin.

Chemischer Informationsdienst, 1986
AbstractThe tanning agents punicalagin (I) and punicalin (II) both form an equilibrium mixture of α,β‐anomers.
G. SCHILLING, H. SCHICK
openaire   +1 more source