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Cardioprotective potential of punicalagin: an evidence-based review
Journal of Asian Natural Products ResearchThis evidence-based review highlights the cardioprotective potential of punicalagin, a major polyphenolic ellagitannin from Punica granatum L., focusing on its pharmacological mechanisms in cardiovascular disease (CVD) pathogenesis. Preclinical studies demonstrate that punicalagin reduces oxidative stress via Nrf2/HO-1 and AMPK pathways, suppresses ...
Gurjeet, Kaur +6 more
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Gastroprotective activity of punicalagin and Lafoensia pacari in mice
Revista Brasileira de Farmacognosia, 2020Lafoensia pacari A. St.-Hil., Lythraceae, is used in Brazilian folk medicine to treat ulcer and gastritis; thus, it is important to conduct research so as to better understand its medicinal properties. The aim of this study was to assess the antisecretory and antiulcerogenic activities of lyophilized aqueous fraction and punicalagin isolated from ...
Beatriz A. Chaibub +5 more
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Development of in situ forming implants for controlled delivery of punicalagin
International Journal of PharmaceuticsDue to efficient drainage of the joint, the development of intra-articular depots for long-lasting drug release is a difficult challenge. Moreover, a disease-modifying osteoarthritis drug (DMOAD) that can effectively manage osteoarthritis has yet to be identified.
Steven H. Elder +5 more
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Characterisation of Pomegranate‐Husk Polyphenols and Semi‐Preparative Fractionation of Punicalagin
Phytochemical Analysis, 2017AbstractIntroductionPomegranate‐husk is the main by‐product generated from the pomegranate industry. It is a potential source of compounds highly appreciated by different costumers. Punicalagin is the main compound present in pomegranate‐husk.ObjectiveTo characterise the pomegranate‐husk total polyphenols by HPLC‐ESI‐MS and to establish a method for ...
Pedro Aguilar‐Zárate +8 more
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Zur Struktur des Punicalagins und Punicalins
Liebigs Annalen der Chemie, 1985AbstractDie Gerbstoffe Punicalagin (1) und Punicalin (2) bilden in Lösung ein α,β‐Anomerengemisch. Die spektroskopischen Daten zeigen, daß diese Moleküle als natürliche Ansa‐Verbindungen angesehen werden können. Unter den Bedingungen der Glycosylierung weicht das System bei 2 in Richtung größerer Beweglichkeit des Makrocyclus aus: Entweder durch ...
Gerhard Schilling, Hartmut Schick
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Immune-suppressive activity of punicalagin via inhibition of NFAT activation
Biochemical and Biophysical Research Communications, 2008Since T cell activation is central to the development of autoimmune diseases, we screened a natural product library comprising 1400 samples of medicinal herbal extracts, to identify compounds that suppress T cell activity. Punicalagin (PCG) isolated from the fruit of Punica granatum was identified as a potent immune suppressant, based on its inhibitory
Sang-Ik, Lee +5 more
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Nephroprotection of punicalagin in rat model of endotoxemic acute kidney injury
Toxicology Mechanisms and Methods, 2016The potential nephroprotection of punicalagin (PNG) against lipopolysaccharide (LPS)-induced acute kidney injury in rats was investigated. Rats received a single i.v. dose of LPS (5 mg/kg), and treated with PNG (50 mg/kg, i.p.), 1 h before, and 1 h following LPS administration.
Amr A, Fouad +2 more
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Punicalagin as a novel tyrosinase and melanin inhibitor: Inhibitory activity and mechanism
LWT - Food Science and Technology, 2022Wei Ming Chai, Xiao-Xin Chen
exaly
Punicalagin Regulates Signaling Pathways in Inflammation-Associated Chronic Diseases
Antioxidants, 2022Feng Z, Lin Zhao
exaly