Disruption of the nucleocapsid-RNA condensation by punicalagin is a broad-spectrum antiviral approach [PDF]
Fundamental ResearchThe formation of liquid condensates by nucleocapsid (N) protein and viral RNA is a critical and highly conserved event in the life cycle of numerous viruses. Targeting this process emerges as a possible strategy to combat viral infections.
Shao-Zhen Jiang +26 more
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Antimicrobial Activity and Mechanisms of Punicalagin against Vibrio parahaemolyticus
FoodsThis study sought to explore the antimicrobial activity of punicalagin against V. parahaemolyticus and its potential modes of action. V. parahaemolyticus ATCC 17802 and RIMD 2210633Sm were exposed to punicalagin, and the energy production, membrane ...
Hongli Liu +3 more
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Antimicrobial and Immunomodulatory Effects of Punicalagin and Meropenem in a Murine Model of Sublethal Sepsis [PDF]
AntibioticsBackground: Punicalagin (Pg), a major ellagitannin derived from pomegranates, possesses antimicrobial, antioxidant, and immunomodulatory properties, suggesting its potential as an adjunctive therapy for sepsis.
Liliane dos Santos Rodrigues +7 more
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Punicalagin Regulates Signaling Pathways in Inflammation-Associated Chronic Diseases [PDF]
Antioxidants, 2021 Inflammation is a complex biological defense system associated with a series of chronic diseases such as cancer, arthritis, diabetes, cardiovascular and neurodegenerative diseases.
Jie Xu +5 more
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Effects of Adding Punicalagin or Oleuropein to TRIS Diluent on Quality of Frozen–Thawed Semen from Rams [PDF]
AnimalsThis study aimed to investigate the effects of adding different levels of punicalagin or oleuropein to TRIS diluent on the quality of frozen–thawed semen from Najdi rams.
Mohamed Shehab-El-Deen +6 more
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Preliminary screening of pomegranate-derived compounds for antimicrobial and anti-virulence effects against cariogenic streptococci [PDF]
Saudi Dental JournalAs a biofilm-mediated disease, dental caries is primarily attributed to the activity of Streptococcus mutans and Streptococcus sobrinus, key contributors to enamel mineral loss under acidic conditions.
Nurhayati Mohamad Zain +3 more
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Punicalagin Inhibits the Growth and Proliferation of Ovarian Epithelial Adenocarcinoma Cells Via Apoptosis and Autophagic Cell Death. [PDF]
J Biochem Mol ToxicolPunicalagin targets ovarian cancer via multiple anti‐cancer mechanisms. This graphical abstract summarizes the key findings of the study on the effects of Punicalagin (PCG), a pomegranate‐derived polyphenol, on ovarian cancer cells (OVCAR‐3 and SKOV‐3).
Bhutta ZA +4 more
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Punicalagin in Cancer Prevention—Via Signaling Pathways Targeting [PDF]
Nutrients, 2021 The extract of pomegranate (Punica granatum) has been applied in medicine since ancient times due to its broad-spectrum health-beneficial properties. It is a rich source of hydrolyzable tannins and anthocyanins, exhibiting strong antioxidative, anti-inflammatory, and antineoplastic properties.
Izabela Berdowska +2 more
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Translational Oncology, 2022 Punicalagin, which is derived from pomegranate peel, is reported to exert growth-inhibitory effects against various cancers. However, the underlying mechanisms have not been elucidated.
Xialin Xie +9 more
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Effect of punicalagin on proliferation of porcine ovarian granulosa cells in vitro [PDF]
Journal of Central European Agriculture, 2016 Punicalagin is a major component responsible for pomegranate's (Punica granatum) antioxidant properties. Punicalagin is the predominant ellagitannin of Punica granatum and present in two isomeric forms: punicalagin α and β.
Dagmara Packová, Adriana Kolesárová
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