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Punicalagin promotes human villous trophoblast differentiation
Placenta, 2016Poor differentiation of trophoblasts is associated with placental dysfunction, predisposing women to multiple pregnancy disorders. Punicalagin, a prominent ellagitannin in pomegranate juice has been shown to exert anti-apoptosis and anti-oxidative effects in human trophoblasts. We hypothesized that punicalagin modulates trophoblast differentiation.
Baosheng, Chen +3 more
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One-Step Purification of Punicalagin by Preparative HPLC and Stability Study on Punicalagin
Separation Science and Technology, 2010A novel, rapid, and high efficiency method to purify natural punicalagin by preparative HPLC is described. The optimum purification condition for punicalagin purification was 14% methanol in 0.1% trifluoroacetic acid solution as the mobile phase. The flow rate was 12 ml/min.
Jingjing Lu, Ke Ding, Qipeng Yuan
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Zur Struktur des Punicalagins und Punicalins
Liebigs Annalen der Chemie, 1985AbstractDie Gerbstoffe Punicalagin (1) und Punicalin (2) bilden in Lösung ein α,β‐Anomerengemisch. Die spektroskopischen Daten zeigen, daß diese Moleküle als natürliche Ansa‐Verbindungen angesehen werden können. Unter den Bedingungen der Glycosylierung weicht das System bei 2 in Richtung größerer Beweglichkeit des Makrocyclus aus: Entweder durch ...
Gerhard Schilling, Hartmut Schick
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Punicalagin attenuates osteoarthritis progression via regulating Foxo1/Prg4/HIF3α axis
Bone, 2021Punicalagin (PUN) is a common anti-inflammatory polyphenol. However, the function and mechanism of PUN in osteoarthritis remains unknown.Chondrocytes were isolated from rats, and confirmed by toluidine blue staining and immunofluorescence. Chondrocytes were challenged by lipopolysaccharide (LPS), and rat osteoarthritis model was established by Hulth ...
FeiFei, Liu +4 more
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Punicalagin alleviates hepatotoxicity in rats challenged with cyclophosphamide
Environmental Toxicology and Pharmacology, 2016This study investigated the possible hepatoprotection of punicalagin in rats received cyclophosphamide (20mg/kg/day, i.p., for 7 days). Punicalagin given at two doses, 15 and 30mg/kg/day, p.o., for 7 days, starting the same day of cyclophosphamide administration.
Amr A, Fouad +2 more
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Antifungal activity of Punicalagin–nystatin combinations against Candida albicans
Oral Diseases, 2020AbstractObjectivesOral candidiasis is the most common opportunistic fungal infection of oral mucosa and results from an overgrowth of Candida, especially Candida albicans. The potential anti‐C. albicans and cytotoxicity of punicalagin (PCG), isolated from Punica granatum, alone or with nystatin (NYS) were evaluated.MethodsActivity of compounds alone or
Rafaela Alves da Silva +8 more
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Punicalagin inhibits neuroinflammation in LPS‐activated rat primary microglia
Molecular Nutrition & Food Research, 2014ScopeIn this study, the effects of punicalagin on neuroinflammation in LPS‐activated microglia were investigated.Methods and resultsThe ability of punicalagin to reduce the production of TNF‐α, IL‐6 and prostaglandin E2 was measured in culture medium using enzyme immunoassay.
Olajide, Olumayokun A. +4 more
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Punicalagin inhibits pro-inflammatory cytokines induced by influenza A virus
European Journal of Integrative Medicine, 2021Abstract Introduction Influenza A virus causes severe pneumonia in humans, leading to high morbidity and mortality. Studies have shown that an excessive immune response in overproduction of pro-inflammatory cytokines can exacerbate complications of influenza virus infection.
Farzad Aghaei +2 more
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Immune-suppressive activity of punicalagin via inhibition of NFAT activation
Biochemical and Biophysical Research Communications, 2008Since T cell activation is central to the development of autoimmune diseases, we screened a natural product library comprising 1400 samples of medicinal herbal extracts, to identify compounds that suppress T cell activity. Punicalagin (PCG) isolated from the fruit of Punica granatum was identified as a potent immune suppressant, based on its inhibitory
Sang-Ik, Lee +5 more
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Gastroprotective activity of punicalagin and Lafoensia pacari in mice
Revista Brasileira de Farmacognosia, 2020Lafoensia pacari A. St.-Hil., Lythraceae, is used in Brazilian folk medicine to treat ulcer and gastritis; thus, it is important to conduct research so as to better understand its medicinal properties. The aim of this study was to assess the antisecretory and antiulcerogenic activities of lyophilized aqueous fraction and punicalagin isolated from ...
Beatriz A. Chaibub +5 more
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