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Characterisation of Pomegranate‐Husk Polyphenols and Semi‐Preparative Fractionation of Punicalagin
Phytochemical Analysis, 2017AbstractIntroductionPomegranate‐husk is the main by‐product generated from the pomegranate industry. It is a potential source of compounds highly appreciated by different costumers. Punicalagin is the main compound present in pomegranate‐husk.ObjectiveTo characterise the pomegranate‐husk total polyphenols by HPLC‐ESI‐MS and to establish a method for ...
Pedro Aguilar‐Zárate +8 more
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Development of in situ forming implants for controlled delivery of punicalagin
International Journal of PharmaceuticsDue to efficient drainage of the joint, the development of intra-articular depots for long-lasting drug release is a difficult challenge. Moreover, a disease-modifying osteoarthritis drug (DMOAD) that can effectively manage osteoarthritis has yet to be identified.
Steven H. Elder +5 more
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Immune-suppressive activity of punicalagin via inhibition of NFAT activation
Biochemical and Biophysical Research Communications, 2008Since T cell activation is central to the development of autoimmune diseases, we screened a natural product library comprising 1400 samples of medicinal herbal extracts, to identify compounds that suppress T cell activity. Punicalagin (PCG) isolated from the fruit of Punica granatum was identified as a potent immune suppressant, based on its inhibitory
Sang-Ik, Lee +5 more
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Nephroprotection of punicalagin in rat model of endotoxemic acute kidney injury
Toxicology Mechanisms and Methods, 2016The potential nephroprotection of punicalagin (PNG) against lipopolysaccharide (LPS)-induced acute kidney injury in rats was investigated. Rats received a single i.v. dose of LPS (5 mg/kg), and treated with PNG (50 mg/kg, i.p.), 1 h before, and 1 h following LPS administration.
Amr A, Fouad +2 more
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Punicalagin as an Artemis inhibitor synergizes with photodynamic therapy in tumor suppression
Bioorganic ChemistryPhotodynamic therapy (PDT) is a minimally invasive treatment that utilizes a photosensitizer, specific light wavelengths, and oxygen to generate reactive oxygen species (ROS), causing oxidative damage and tumor cell death. However, the effectiveness of PDT can be reduced by the intrinsic antioxidant and DNA repair mechanisms of tumor cells.
Xuening, Chen +4 more
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Punicalagin as a novel tyrosinase and melanin inhibitor: Inhibitory activity and mechanism
LWT - Food Science and Technology, 2022Xiao-Xin Chen, Wei-Ming Chai
exaly
Punicalagin Regulates Signaling Pathways in Inflammation-Associated Chronic Diseases
Antioxidants, 2022Jie Xu, Ke Cao, Xuyun Liu
exaly