Potentiated virucidal activity of pomegranate rind extract (PRE) and punicalagin against Herpes simplex virus (HSV) when co-administered with zinc (II) ions, and antiviral activity of PRE against HSV and aciclovir-resistant HSV [PDF]
, 2017 Background There is a clinical need for new therapeutic products against Herpes simplex virus (HSV). The pomegranate, fruit of the tree Punica granatum L, has since ancient times been linked to activity against infection. This work probed the activity of
Bugert, Joachim J. +3 more
core +3 more sources
Anthelmintic Activity of Punicalagin from nogeissus Leiocarpus [PDF]
Universal Journal of Plant Science, 2015 Leaves of Anogeissus leiocarpus Guill. & Perr. have been traditionally used as an African botanical treatment for parasitic worm infections in both humans and livestock. This current study documents the presence of punicalagin isomers (α & β) and its galloyl ester, 1-O-galloyl-punicalagin as major components in the leaf extract of A.
Carrie Waterman +6 more
openaire +1 more source
Biomolecules, 2020 Pomegranate (Punica granatum) is a well-established folklore medicine, demonstrating benefits in treating numerous conditions partly due to its antimicrobial and anti-inflammatory properties. Such desirable medicinal capabilities are attributed to a high
Vildan Celiksoy +4 more
doaj +1 more source
Punicalagin Induces Serum Low‐Density Lipoprotein Influx to Macrophages [PDF]
Oxidative Medicine and Cellular Longevity, 2016 High levels of circulating low‐density lipoprotein (LDL) are a primary initiating event in the development of atherosclerosis. Recently, the antiatherogenic effect of polyphenols has been shown to be exerted via a mechanism unrelated to their antioxidant capacity and to stem from their interaction with specific intracellular or plasma proteins. In this
Dana Atrahimovich +4 more
openaire +2 more sources
Identification of Hydrolyzable Tannins (Punicalagin, Punicalin and Geraniin) as Novel inhibitors of Hepatitis B Virus Covalently Closed Circular DNA [PDF]
, 2016 The development of new agents to target HBV cccDNA is urgently needed because of the limitations of current available drugs for treatment of hepatitis B.
Cai, Dawei +6 more
core +1 more source
Pomegranate ellagitannins inhibit α-glucosidase activity in vitro and reduce starch digestibility under simulated gastro-intestinal conditions [PDF]
, 2014 Pomegranate extract was tested for its ability to inhibit α-amylase and α-glucosidase activity. Pomegranate extract strongly inhibited rat intestinal α-glucosidase in vitro whereas it was a weak inhibitor of porcine α-amylase. The inhibitory activity was
BELLESIA, ANDREA +2 more
core +1 more source
Punicalagin Regulates Key Processes Associated with Atherosclerosis in THP-1 Cellular Model
Pharmaceuticals, 2020 Atherosclerosis may lead to cardiovascular diseases (CVD), which are the primary cause of death globally. In addition to conventional therapeutics for CVD, use of nutraceuticals that prevents cholesterol deposition, reduce existing plaques and hence anti-
Sanaa Almowallad +5 more
doaj +1 more source
In vitro permeation and biological activity of punicalagin and zinc (II) across skin and mucous membranes prone to Herpes simplex virus infection [PDF]
, 2017 Coadministration of pomegranate rind extract (PRE) and zinc (II) ions has recently been reported as a potential new topical treatment for Herpes simplex virus (HSV) infections. In the current work we examined the in vitro topical delivery of punicalagin (
Bugert, Joachim J. +4 more
core +1 more source
Plants, 2021 This investigation focused on the qualitative and quantitative composition of polyphenolic compounds of Mediterranean northern shore Cistus creticus and six further, partly sympatric Cistus species (C. albidus, C. crispus, C. ladanifer, C. monspeliensis,
Brigitte Lukas +5 more
doaj +1 more source
Myricetin, the main flavonoid in Syzygium cumini leaf, is a novel inhibitor of platelet thiol isomerases PDI and ERp5 [PDF]
, 2020 Background: Flavonoids have been characterized as a prominent class of compounds to treat thrombotic diseases through the inhibition of thiol isomerases. Syzygium cumini is a flavonoid-rich medicinal plant that contains myricetin and gallic acid.
Ayyanar +45 more
core +1 more source