Results 71 to 80 of about 3,654 (184)

Harnessing Natural Compounds in Psoriasis: Targeting Cellular Pathways for Effective Therapy

Phytotherapy Research, Volume 40, Issue 8, Page 4759-4791, August 2026.
Natural compounds act on key cellular pathways in psoriasis by suppressing keratinocyte hyperproliferation, modulating Th17/IL‐17‐mediated immune responses, and reducing oxidative stress. These multi‐target effects highlight their potential as safer adjunctive therapies alongside conventional treatments.
Hye Jin Lee, Yu Jin So, Il‐Joo Jo, Ji Yong Jang, Tae Han Yook, Jun Ho Lee, Sung Wook Kim, Kangwook Lee, Soo Jung Park, Gabsik Yang   +9 more
wiley   +1 more source

Table1_Inhibitory Effect of Punicalagin on Inflammatory and Angiogenic Activation of Human Umbilical Vein Endothelial Cells.pdf

, 2021
Punicalagin, a major ellagitannin isolated from pomegranate, is proved to have various pharmacological activities with an undefined therapy mechanism. The objective of this research was to demonstrate the effect of punicalagin on anti-inflammatory and ...
Mingcheng Huang (11711672), Xuemei Zhang (89768), Xiaohua Wang (255149), Yanghui Ou (11711666), Yumeng Yang (8155002), Buling Wu (561254), Liqi Huang (11711669), Wei Liu (20030)   +7 more
core   +1 more source

Punicalagin and Ketogenic Amino Acids Loaded Organic Lipid Carriers Enhance the Bioavailability, Mitochondrial β-Oxidation, and Ketogenesis in Maturing Adipocytes

Nanomaterials, 2022
The identification of lipolytic bioactive compounds via the functional stimulation of carbohydrate response element-binding protein-1 (CREBp-1) and AMP-activated protein kinase (AMPK) is most warranted.
Pandurangan Subash-Babu, Nouf Al-Numair, Tahani Almuzaini, Jegan Athinarayanan, Ali Abdullah Alshatwi   +4 more
doaj   +1 more source

Pomegranate Peel Polyphenol Extract Ameliorates Hyperuricemia by Inhibiting Uric Acid Synthesis and Reabsorption

Chemical Biology &Drug Design, Volume 108, Issue 2, August 2026.
The graphical abstract illustrates the action mechanisms through which PPE alleviates HUA by inhibiting XOD activity, and by suppressing the PI3K‐AKT signaling pathway to downregulate the expression of the urate reabsorption transporters URAT1 and GLUT9, thereby promoting renal UA excretion and attenuating renal injury.
Zeyu Yin, Shufei Liang, Gangao Yang, Pingping Guo, Chao Wang, Qingqing Han, Xinhua Song   +6 more
wiley   +1 more source

Cardioameliorative effect of punicalagin against streptozotocin-induced apoptosis, redox imbalance, metabolic changes and inflammation [PDF]

, 2015
The effect of punicalagin on metabolic risks, oxidative stress, inflammation, cardiac apoptosis and histopathological alterations in experimentally induced diabetes was addressed. Diabetes was induced in male rats by a single injection of streptozotocin (
Hemieda, Faried A.E., Othman, Azza I., Abdulhadi, Haitham L., El-Missiry, Mohamed A., Sakr, Doaa A., Amer, Maher A.   +5 more
core   +1 more source

Nuclear factor of activated T cells as a driver of tumor progression and a target for precision therapy

Animal Models and Experimental Medicine, Volume 9, Issue 7, Page 1338-1352, July 2026.
Overview illustration of dysregulated NFAT activation coordinating upstream signaling, post‐translational regulation and cancer promoting pathways to induce abnormal gene expression that drives tumor development, progression and immune escape. Abstract The Nuclear Factor of Activated T Cells (NFAT) family comprises closely related transcription factors.
Hira Khan, Khushbakhat Alia, Yusra Al Dhaheri, Muhammad Naseem, Rabah Iratni, Edgar Serfling, Khalid Muhammad   +6 more
wiley   +1 more source

Comparative analysis of the phenolic contents and antioxidant activities of different parts of two pomegranate (Punica granatum L.) Cultivars: ‘Tunisia’ and ‘Qingpi’

Frontiers in Plant Science, 2023
Pomegranate (Punica granatum L.), with its abundant phenolic substances and strong antioxidant activity, holds significant research and utilization potential across various organs.
Huifen Zhang, Miao Wang, Guoqiang Yu, Jing Pu, Kun Tian, Xiaofu Tang, Ying Du, Hongxia Wu, Jiong Hu, Xian Luo, Lijin Lin, Qunxian Deng   +11 more
doaj   +1 more source

Research on the Mechanism of Natural Products Acting on Chronic Obstructive Pulmonary Disease

Food Science &Nutrition, Volume 14, Issue 7, July 2026.
This figure illustrates that approximately 80 natural compounds exert therapeutic effects against chronic obstructive pulmonary disease by targeting pathological mechanisms such as airway inflammation, oxidative stress, airway remodeling, mucus hypersecretion, emphysema, protease–antiprotease imbalance, apoptosis, and autophagy.
Shuna Wei, Xiaoju Liu
wiley   +1 more source

Polyphenolic Components and Phytochemicals Deployed as Nutraceuticals and Pharmafoods

Food Science &Nutrition, Volume 14, Issue 7, July 2026.
This review (2010–2025) highlights the therapeutic potential of dietary polyphenols against cancer, diabetes, cardiovascular, neurological, and inflammatory diseases. It summarizes molecular mechanisms, clinical evidence, nanoparticle‐based delivery, bioavailability, safety, toxicity, and future prospects supporting polyphenols as promising therapeutic
Subhash Chandra, Md. Sakib Al Hasan, Md. A. K. Azad, Atasi Goswami   +3 more
wiley   +1 more source

Evaluation of Punicalagin Niosomes for Skin Aging

, 2021
Skin aging is one of the most common problems facing humanity. It occurs because of altering the balance between free radicals and antioxidants and increasing the amount of the reactive oxygen species (ROS) in skin cells, which leads to oxidative stress especially when exposed to UV radiation. Antioxidants can neutralize the harmful effects of ROS, and
Ebtesam A. Mohamad, Aya A. Aly, Aya A. Khalaf, Mona I. Ahmed, Reham M. Kamel, Sherouk M. Abdelnaby, Yasmine H. Abdelzaher, Marize G. Sedrak, Shaker A. Mousa   +8 more
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