Results 31 to 40 of about 3,672 (187)

Antimicrobial and Immunomodulatory Effects of Punicalagin and Meropenem in a Murine Model of Sublethal Sepsis

Antibiotics
Background: Punicalagin (Pg), a major ellagitannin derived from pomegranates, possesses antimicrobial, antioxidant, and immunomodulatory properties, suggesting its potential as an adjunctive therapy for sepsis.
Liliane dos Santos Rodrigues, Priscila Mendonça Mendes, André Alvares Marques Vale, José Lima Pereira-Filho, Elizabeth Soares Fernandes, Joicy Cortez de Sá Sousa, Márcia Cristina Gonçalves Maciel, Valério Monteiro-Neto   +7 more
doaj   +2 more sources

Punicalagin, a pomegranate polyphenol sensitizes the activity of antibiotics against three MDR pathogens of the Enterobacteriaceae

BMC Complementary Medicine and Therapies
Background Multidrug resistance (MDR) in the family Enterobacteriaceae is a perniciously increasing threat to global health security. The discovery of new antimicrobials having the reversing drug resistance potential may contribute to augment and revive ...
Saba Kiran, Anam Tariq, Shoaib Iqbal, Zubera Naseem, Waqar Siddique, Sobia Jabeen, Rizwan Bashir, Ashfaq Hussain, Moazur Rahman, Fazal-e Habib, Waqar Rauf, Aamir Ali, Yasra Sarwar, Georg Jander, Mazhar Iqbal   +14 more
doaj   +2 more sources

Punicalagin Inhibits African Swine Fever Virus Replication by Targeting Early Viral Stages and Modulating Inflammatory Pathways

Veterinary Sciences
African swine fever (ASF), caused by the African swine fever virus (ASFV), has resulted in significant losses in the global pig industry. Considering the absence of effective vaccines, developing drugs against ASFV may be a crucial strategy for its ...
Renhao Geng, Dan Yin, Yingnan Liu, Hui Lv, Xiaoyu Zhou, Chunhui Bao, Lang Gong, Hongxia Shao, Kun Qian, Hongjun Chen, Aijian Qin   +10 more
doaj   +2 more sources

Anticancer effects of punicalagin and 5-fluorouracil on laryngeal squamous cell carcinoma: an in vitro study [PDF]

Italian Journal of Medicine
The purpose of this study was to assess the apoptotic effects of punicalagin alone and in combination with 5-fluorouracil (5-FU) on laryngeal squamous cell carcinoma (Hep-2) cell line.
Amany M. Taha, Eman Abd-Elshafy, Asmaa M. Khalifa, Najla Dar-Odeh, Shadia Elsayed, Daniah S. Alharkan, Aishah Alhodhodi, Ahmed Mohammed Sapri, Yassmeen SalahEldin Ragheb, Gihan A. Balbola   +9 more
doaj   +2 more sources

Punicalagin-enriched edible coatings from revalorized pomegranate peels for quality enhancement of fresh-cut celery. [PDF]

J Sci Food Agric
Abstract BACKGROUND Pomegranate peel is a rich source of phenolics, particularly punicalagin, but its valorization for fresh produce preservation requires stabilization. This study aimed to develop and evaluate freeze‐dried encapsulates of pomegranate peel extracts as ingredients in edible coatings for fresh‐cut celery. Pomegranate peels were extracted
Martínez-Zamora L, Zapata R, Cano-Lamadrid M, Artés-Hernández F.   +3 more
europepmc   +2 more sources

In Vitro Studies on the Binding, Antioxidant, and Cytotoxic Actions of Punicalagin

Journal of Agricultural and Food Chemistry, 2007
The protective bioactivity of punicalagin, a high molecular weight polyphenol isolated from pomegranate fruit pith and carpellary membrane, against oxidative damages to lipids, amino acids constituting the proteins, and guanosine as a model for DNA has been investigated.
Anand P, Kulkarni, H S, Mahal, S, Kapoor, S M, Aradhya   +3 more
openaire   +3 more sources

Punicalagin in Cancer Prevention—Via Signaling Pathways Targeting [PDF]

Nutrients, 2021
The extract of pomegranate (Punica granatum) has been applied in medicine since ancient times due to its broad-spectrum health-beneficial properties. It is a rich source of hydrolyzable tannins and anthocyanins, exhibiting strong antioxidative, anti-inflammatory, and antineoplastic properties.
Izabela Berdowska, Małgorzata Matusiewicz, Izabela Fecka   +2 more
openaire   +3 more sources

Punicalagin promotes autophagic degradation of human papillomavirus E6 and E7 proteins in cervical cancer through the ROS-JNK-BCL2 pathway

Translational Oncology, 2022
Punicalagin, which is derived from pomegranate peel, is reported to exert growth-inhibitory effects against various cancers. However, the underlying mechanisms have not been elucidated.
Xialin Xie, Liuyi Hu, Lulu Liu, Jiuru Wang, Yongai Liu, Li Ma, Guangying Sun, Changfei Li, Haji Akber Aisa, Songdong Meng   +9 more
doaj   +1 more source

The Neuroprotective Effect of a Waste Byproduct Obtained From Pomegranate (Punica granatum). [PDF]

Phytother Res
The Effect of a Waste Byproduct Obtained From Pomegranate on Neurodegeneration. ABSTRACT Pomegranate is an exceptional fruit that can have several beneficial effects on human health. The peel of pomegranate, a waste product, should be recovered as it still contains valuable constituents, including phenolic compounds, minerals and fibre. The recovery of
Maiuolo J, Mazza V, Caminiti R, Oppedisano F, Nucera S, Ragusa S, Ilari S, Passacatini LC, Tucci L, Trunfio G, Mollace V, Muscoli C.   +11 more
europepmc   +2 more sources

Punicalagin Damages the Membrane of Salmonella Typhimurium

Journal of Food Protection, 2020
Salmonella, a bacterial foodborne pathogen, can contaminate meat, milk, and vegetables. While appropriate measures are available to control Salmonella, the inhibitory phytochemicals from plants are gaining increased attention. Punicalagin, a natural antimicrobial, is one of the main active tannins isolated from Punica granatum L.
Guanghui Li, Yunfeng Xu, Liang Pan, Xiaodong Xia   +3 more
openaire   +2 more sources