Results 41 to 50 of about 1,943,263 (290)

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit   +11 more
wiley   +1 more source

Is Reward A Punishment? from Reward Addiction to Sensitivity to Punishment

open access: yesInternational Journal of Psychology and Educational Studies, 2018
This study introduces the topics of reward addiction and sensitivity to punishment in academic contexts to the literature. This study was designed firstly to develop reliable and valid measurement tools that can measure high school students' reward addiction and sensitivity to punishment in academic contexts, and secondly to test the structural ...
openaire   +3 more sources

A Two‐Stage Questionnaire and Actigraphy Screening for iRBD in a Multicenter Retrospective Cohort

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Isolated rapid‐eye‐movement sleep behavior disorder is a prodromal marker of synucleinopathies. However, most cases remain undiagnosed due to the insufficient predictive value of questionnaires and limited access to confirmatory video‐polysomnography. We assessed a two‐stage screening strategy combining a brief questionnaire on rapid‐
Caleb A. Massimi   +17 more
wiley   +1 more source

Electroencephalographic Normalization as a Biomarker of Clinical Recovery in Down Syndrome Regression Disorder

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Down syndrome regression disorder is a syndrome characterized by subacute loss of cognitive, behavioral, and functional abilities in individuals with Down syndrome. Electroencephalography abnormalities are frequently observed during evaluation, but it remains unclear whether these findings represent a dynamic marker of disease ...
Jonathan D. Santoro   +14 more
wiley   +1 more source

Punishment insensitivity emerges from impaired contingency detection, not aversion insensitivity or reward dominance

open access: yeseLife, 2019
Our behaviour is shaped by its consequences – we seek rewards and avoid harm. It has been reported that individuals vary markedly in their avoidance of detrimental consequences, that is in their sensitivity to punishment.
Philip Jean-Richard-dit-Bressel   +4 more
doaj   +1 more source

Arterial Spin‐Labeling MRI at the Cortical‐CSF Interface: A Novel Biomarker in Alzheimer Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background/Objective Arterial spin‐labeling (ASL) MRI can measure perfusion signal adjacent to CSF spaces and may provide information regarding CSF‐adjacent water transport physiology. We developed an automated pipeline to extract cortical‐CSF interface (IF) perfusion for comparison between Alzheimer disease (AD) and cognitively normal ...
Mona Asghariahmadabad   +22 more
wiley   +1 more source

Reward- and Punishment-Sensitive Relational Mechanisms: Gender Asymmetries in Dyadic Coping and Relationship Satisfaction

open access: yesStudia Universitatis Babeş-Bolyai. Theologia Reformata Transylvanica
THEORETICAL BACKGROUND – Relationship satisfaction is not merely an individual experience but a phenomenon that emerges through partners’ interactions, in which the coping behaviours of both individuals play a crucial role.
Andrea FERENCZI, Veronika MÉSZÁROS
doaj   +1 more source

The commission of crime from the perspective of decision-making differences

open access: yesFrontiers in Psychology, 2022
A criminal act can be regarded as an irrational decision-making process. Therefore, understanding differences in the criminal decision-making process would shed light on criminal behavior.
Jiaxi Peng   +5 more
doaj   +1 more source

Multiple mediators of reward and punishment sensitivity on loneliness [PDF]

open access: yesPersonality and Individual Differences, 2015
The purpose of this paper was to use the revised Reinforcement Sensitivity Theory as a framework to understand loneliness. We expected higher loneliness to be associated with high reward sensitivity and low punishment sensitivity. We tested how reward and punishment sensitivity could affect loneliness by exploring potential mediators including shyness,
Clark, D. Matthew T.   +2 more
openaire   +5 more sources

Subjective Cognitive Concerns and Cognitive Trajectories in Parkinson's Disease: Biomarker Impact

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the relationship of subjective cognitive concerns (SCC) with biomarkers of Alzheimer's disease (AD), neurodegeneration, and Parkinson's disease (PD) and domain‐specific cognitive trajectories among cognitively unimpaired persons with de novo PD. Method Cognitively unimpaired participants with SCC (n = 294) and without SCC (
Francesca V. Lopez   +5 more
wiley   +1 more source

Home - About - Disclaimer - Privacy