Results 41 to 50 of about 166,378,893 (241)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Conditions Of Stability Loss During The Test Of Hydraulic Forming Of Drawpieces [PDF]

, 2015
The paper contains two parts. In the first part, basic relationships were derived and some problems connected with stability loss during hydraulic forming of round metallic drawpieces with liquid pressure were discussed.
Śloderbach, Z., Z. Śloderbach
core   +1 more source

State-of-the-art and prospects of direct stability assessment methods for second-generation intact stability criteria

Zhongguo Jianchuan Yanjiu
Intact stability of ships in waves is a fundamental guarantee for navigation safety. The direct stability assessment methods associated with the Second Generation Intact Stability Criteria (SGISC) remain undeveloped and have become a key focus of current
Min GU, Jilong CHU, Peijie ZHANG, Shuxia BU   +3 more
doaj   +1 more source

Hyperbranched polysiloxane functionalized graphene oxide for dicyclopentadiene bisphenol dicyanate ester nanocomposites with high performance

eXPRESS Polymer Letters, 2014
We report an efficient and novel method to functionalize graphene oxide (GO) with hyperbranched polysiloxane and successfully compound them with dicyclopentadiene bisphenol dicyanate ester (DCPDCE) to prepare nanocomposites.
H. X. Yan, M. M. Zhang, C. Gong, T. T. Li   +3 more
doaj   +1 more source

Experimental investigation of indirect heat transfer through a novel designed lab-scale setup using functionalized MWCNTs nanofluids (MWCNTs-COOH/water and MWCNTs- OH/water)

Case Studies in Thermal Engineering, 2023
This study aims to investigate the influence of functionalized multi-walled carbon nanotubes (MWCNTs-COOH and MWCNTs-OH) on the performance of a novel indirect laboratory heater redesigned with a helical tube.
Nazanin Karimi Bakhtiyar, Sama Esmaeili, Reza Javadpour, Saeed Zeinali Heris   +3 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Case studies of SGISC Operational Limitations for pure loss of stability and excessive acceleration

, 2021
The present paper reports an application of Operational Limitations related to route and to maximum significant wave height, on two case studies, a Ro-Ro cargo and a bulk carrier. The ships have been found vulnerable to Level 2 for pure loss of stability
Rinauro B., Boccadamo Guido, Begovic E., Rosano G.   +3 more
core  

Chemical speciation of environmentally significant metals with inorganic ligands Part 2: The Cu2+-OH-, Cl-, CO32-, SO42-, and PO43- systems [PDF]

, 2007
Complex formation between CuII and the common environmental ligands Cl-, OH-, CO32-, SO42-, and PO43- can have a significant effect on CuII speciation in natural waters with low concentrations of organic matter.
Powell, K.J., Sjöberg, S., Hans Wanner, Brown, P.L., Byrne, Robert H., Powell, Kipton J., Gajda, T., Paul L. Brown, Gajda, Tamás, Sjöberg, Staffan, Tamas Gajda, Hefter, Glenn, Robert H. Byrne, Byrne, R.H., Kipton J. Powell, Sjöberg, Staffan,, Hefter, G., Wanner, H., Staffan Sjoberg, Wanner, Hans, Glenn Hefter, Brown, Paul L.   +21 more
core   +2 more sources

Second Generation IMO Intact Stability Vulnerability Criteria and its Application to ships Navigating in Persian Gulf and Oman Sea

International Journal of Maritime Technology, 2017
Second generation intact stability criteria for few past years had been under development by International Maritime Organization (IMO). Since the draft proposed amendments shall be amended to International code on Intact Stability (IS code 2008), new ...
Esmaeel Masoudi
doaj