Results 51 to 60 of about 934,364 (239)

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

某污水厂MBR膜超年限运行的关键因素评估

Jingshui jishu
【目的】膜生物反应器(MBR)工艺因其出水水质好和占地面积小等优点在城镇污水处理领域(尤其是地下污水处理厂)应用广泛，但膜材质固有缺陷引发的长期运行问题(高断丝率、膜通量衰减、出水水质波动),成为制约MBR发展的首要影响因素，且导致其工艺投资及运行成本均较高。【方法】华南地区某市政污水厂MBR运营人员通过优化工艺调控策略，将设计寿命为5年的中空纤维超滤膜的实际运行寿命延长至10年，且该批MBR出水水质优于一级A标准，并未出现明显的截留效能下降问题 ...
CHEN Zebin, ZHANG Yingyu, TANG Xia
doaj   +1 more source

The effect of refined nursing intervention on patients undergoing maintenance hemodialysis in the hemodialysis center during the COVID-19 epidemic

BMC Nursing, 2021
Background The outbreak of novel coronavirus pneumonia has exerted considerable psychological pressure on patients undergoing hemodialysis, resulting in unhealthy psychological emotions.
Qing-Lai Zhang, Shuo Wang, Yue Zhang, Fei Meng   +3 more
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

HBP21 Alleviates Sepsis-Induced Acute Kidney Injury by Targeting PI3K/AKT-Mediated M1 Macrophage Polarization

Mediators of Inflammation
Conclusion: These findings suggest that HBP21 mitigates S-AKI pathogenesis via PI3K/AKT-mediated M2 macrophage polarization, underscoring its translational potential in renal injury therapy.
Na An, Mingzhi Xu, Ruman Chen, Cuijuan Wang, Yafei Bai   +4 more
doaj   +1 more source

Association between the serum uric acid-to-creatinine ratio and cardiovascular mortality in maintenance hemodialysis patients

Renal Failure
Background Uric acid is a risk factor for death in hemodialysis patients, but its exact role is still unclear. The serum uric acid-to-serum creatinine (SUA/SCr) ratio is a new indicator. This study aimed to clarify the relationship between this indicator
Wanqing Huang, Ning Ding, Yanping Zhang, Dongxia Qiu, Lin Wei, Chen Zhao, Zhuo Ren, Qian Wang, Kaiming Ren, Jiuxu Bai, Ning Cao   +10 more
doaj   +1 more source

Molecular mechanisms of hydrogen sulfide against uremic accelerated atherosclerosis through cPKCβII/Akt signal pathway

BMC Nephrology, 2019
Background Cardiovascular disease is the most common complication and leading cause of death in maintenance hemodialysis patients. The protection mechanism of hydrogen sulfide (H2S) and the specific role of conventional protein kinase C βII (cPKCβII)/Akt
Ruifang Xiong, Xiangxue Lu, Jinghong Song, Han Li, Shixiang Wang   +4 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Willingness and influencing factors of adults receiving Hemodialysis to use mobile healthcare apps: a cross-sectional study

BMC Nephrology
Purpose Grounded on the Technology Acceptance Model and integrating theories of perceived risk and trust, this study explores the willingness of adults receiving hemodialysis to use mobile healthcare application services as well as its influencing ...
Jun Xu, Suping Guo, Xintao Yu, Xiaojing Ji   +3 more
doaj   +1 more source

Integrated management is effective in the prevention and control of COVID-19 in the blood purification center: joint efforts from multiple departments

Renal Replacement Therapy, 2021
Background During the outbreak of new coronavirus pneumonia, many hospitals in China became the designated hospitals for the treatment of new coronavirus pneumonia.
Jinmei Yin, Jun Yin, Zhiwu Tian, Peiqiu Li, Xiaoqiu Chen   +4 more
doaj   +1 more source