Results 101 to 110 of about 20,168 (266)
Journal of the World Aquaculture Society, Volume 56, Issue 2, April 2025.Abstract Metabolism plays a crucial role in the growth rate of species. Proteomics serves as a potent tool to explore these metabolic changes. Herein, we investigated the metabolic growth differences in Gymnocypris przewalskii (GP) and Gymnocypris ecklon (GE). After 9 months of culture, the growth rate of GP was slower than that of GE (p < 0.05), while
Junming Zhou, Yun Zhao
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Analysis of Multiple Isoenzyme Expression Among Twenty-Two Species of Mycoplasma and Acholeplasma [PDF]
, 1981 Crude extracts of triple-cloned, purified cultures of 22 species of Mycoplasma and Acholeplasma were examined for expression of 21 isozyme systems routinely used to type mammalian cells. Nine previously described enzymes (purine nucleoside phosphorylase,
Barile, Michael F. +3 more
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Triazole-Based Compound as a Candidate To Develop Novel Medicines To Treat Toxoplasmosis [PDF]
, 2014 This article reports anti-Toxoplasma gondii activity of 3-(thiophen-2-yl)-1,2,4-triazole-5-thione. The compound displayed significant and reproducible antiparasitic effects at nontoxic concentrations for the host cells, with an experimentally determined
Dzitko, Katarzyna +5 more
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Purine nucleoside phosphorylase as a target to treat age-associated lower urinary tract dysfunction
Nature reviews. Urology, 2022 L. Birder, E. Jackson
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Inhibition and Structure of Toxoplasma gondii Purine Nucleoside Phosphorylase
Eukaryotic Cell, 2014 The intracellular pathogen Toxoplasma gondii is a purine auxotroph that relies on purine salvage for proliferation. We have optimized T. gondii purine nucleoside phosphorylase (TgPNP) stability and crystallized TgPNP with phosphate and immucillin-H, a ...
T. Donaldson +9 more
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The FASEB Journal, Volume 39, Issue 5, 15 March 2025.Human adenovirus serotype 5 was used to infect HEK293 fibroblasts at low MOI (0.5, 1.0, and 2.0). Infected cells were interrogated by gas chromatography time‐of‐flight mass spectrometry (GC‐TOF‐MS) at 6, 12, 24, and 36 h post‐infection. The total metabolites were evaluated using an untargeted analysis of primary carbons. The results indicate a decrease
Bailey‐J C. Sanchez +2 more
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PLoS ONE, 2018 Schistosomiasis affects million people and its control is widely dependent on a single drug, praziquantel. Computational chemistry has led to the development of new tools that predict molecular properties related to pharmacological potential.
Jefferson A Rocha +9 more
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Enzyme kinetics, structural analysis and molecular modeling studies on a series of Schistosoma mansoni PNP inhibitors [PDF]
, 2011 The enzyme purine nucleoside phosphorylase from Schistosoma mansoni (SmPNP) is an attractive molecular target for the development of novel drugs against schistosomiasis, a neglected tropical disease that affects about 200 million people worldwide. In the
ANDRICOPULO, Adriano Defini +6 more
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Purine nucleoside phosphorylase controls nicotinamide riboside metabolism in mammalian cells
Journal of Biological Chemistry, 2022 A. Kropotov +13 more
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ChemistryEurope, Volume 3, Issue 2, March 10, 2025.A computational investigation of the reported abiotic phosphorylation of ribose and the subsequent formation of ribonucleosides reveals that the most plausible reaction mechanism involves the protonation of ribose, followed by carbocation formation and an SN2 substitution step.
Maciej Piejko +3 more
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