Results 71 to 80 of about 24,465 (266)

Purine nucleoside phosphorylase from Schistosoma mansoni in complex with ribose-1-phosphate [PDF]

, 2011
A binary complex between a low-molecular-weight purine nucleoside phosphorylase and ribose-1-phosphate is described for the first time and comparisons with known ternary complexes are ...
D’Muniz Pereira, Humberto, Garratt, Richard Charles, Oliva, Glaucius   +2 more
core   +2 more sources

Characterization of a Schistosoma mansoni NDPK expressed in sexual and digestive organs [PDF]

, 2019
Nucleoside diphosphate kinases (NDPKs) are crucial to keep the high triphosphate nucleotide levels in the biological process. The enzymatic mechanism has been extensively described; however, the structural characteristics and kinetic parameters have ...
Balasco Serrão, VH Balasco, Bird, LE, Brandão-Neto, J, D'Muniz Pereira, H D'Muniz, De Freitas Fernandes, A, Demarco, R, Nettleship, JE, Owens, Raymond, Romanello, L, Torini, JR, Zeraik, AE   +10 more
core   +2 more sources

Structure of grouper iridovirus purine nucleoside phosphorylase [PDF]

Acta Crystallographica Section D Biological Crystallography, 2010
Purine nucleoside phosphorylase (PNP) catalyzes the reversible phosphorolysis of purine ribonucleosides to the corresponding free bases and ribose 1-phosphate. The crystal structure of grouper iridovirus PNP (givPNP), corresponding to the first PNP gene to be found in a virus, was determined at 2.4 Å resolution.
Jing Wen Ting, You Na Kang, Paula W. Allan, William B. Parker, Chi Yao Chang, Steven E. Ealick, Yang Zhang   +6 more
openaire   +3 more sources

Evidence for purine nucleoside phosphorylase (PNP) release from rat C6 glioma cells

Journal of Neurochemistry, 2017
Intracellular purine turnover is mainly oriented to preserving the level of triphosphate nucleotides, fundamental molecules in vital cell functions that, when released outside cells, act as receptor signals.
P. Giuliani, M. Zuccarini, S. Buccella, Luis Emiliano Peña-Altamira, E. Polazzi, M. Virgili, Barbara Monti, A. Poli, M. Rathbone, P. Di Iorio, R. Ciccarelli, F. Caciagli   +11 more
semanticscholar   +1 more source

Adjusting Cell‐Surface Interactions Through a Covalent Immobilization of Biomolecules

Advanced Materials Interfaces, EarlyView.
This review presents an overview of current and emerging immobilization techniques coupled with an in‐depth investigation of the underlying mechanisms governing the activity and stability of covalently immobilized biomolecules. The aim of this study is to serve as a guide for the development of long‐lasting biomedical coatings with versatile biological
Sara Shakibania, Manus J. P. Biggs, Katarzyna Krukiewicz   +2 more
wiley   +1 more source

Purine Metabolism and Dystonia: Perspectives of a Long‐Promised Relationship

Annals of Neurology, EarlyView.
Purine pool imbalance in purine metabolism disorders, such as Lesch–Nyhan disease, intersects with dystonia pathogenesis. The recent discovery of gain‐of‐function IMPDH2 pathogenic variants in patients with prominent dystonic manifestations provides new insights into the link between dystonia and purinergic system defects.
Ugo Sorrentino, Audrey G. O'Neill, Justin M. Kollman, Hyder A. Jinnah, Michael Zech   +4 more
wiley   +1 more source

Ischemic nucleotide breakdown increases during cardiac development due to drop in adenosine anabolism/catabolism ratio [PDF]

, 1990
Our earlier work on reperfusion showed that adult rat hearts released almost twice as much purine nucleosides and oxypurines as newborn hearts did [Am J Physiol 254 (1988) H1091].
Huizer, T. (Tom), Jong, J.W. (Jan Willem) de, Keijzer, E. (Elisabeth), Schoutsen, B.   +3 more
core   +2 more sources

Engineering Substrate Promiscuity of Nucleoside Phosphorylase Via an Insertions–Deletions Strategy

JACS Au
Nucleoside phosphorylases (NPs) are the key enzymes in the nucleoside metabolism pathway and are widely employed for the synthesis of nucleoside analogs, which are difficult to access via conventional synthetic methods.
Gaofei Liu, Jialing Wang, Jianlin Chu, Tianyue Jiang, Song Qin, Zhen Gao, Bingfang He   +6 more
semanticscholar   +1 more source

The ligand binding mechanism to purine nucleoside phosphorylase elucidated via molecular dynamics and machine learning

Nature Communications, 2015
The study of biomolecular interactions between a drug and its biological target is of paramount importance for the design of novel bioactive compounds.
S. Decherchi, Anna Berteotti, G. Bottegoni, W. Rocchia, A. Cavalli   +4 more
semanticscholar   +1 more source

Rapid and chemically diverse C transfer from trees to mycorrhizal fruit bodies in the forest

Functional Ecology, EarlyView.
Read the free Plain Language Summary for this article on the Journal blog. Abstract Ectomycorrhizal fungi (EMF) are common belowground tree symbionts, supplying trees with water and nutrients. In return, large amounts of C assimilated by trees can be allocated into EMF. However, the chemical forms in which the C is transferred from trees to fungi under
Alon Rapaport, Stav Livne‐Luzon, Hagar Fox, Yaara Oppenheimer‐Shaanan, Tamir Klein   +4 more
wiley   +1 more source