Results 71 to 80 of about 14,227 (210)

The Role of the Intestinal Microbiome in the Pathogenesis and Treatment of Hyperuricemia: A Review

Food Science &Nutrition, Volume 13, Issue 10, October 2025.
This review summarizes the characteristics, prevalence, and treatment strategies of hyperuricemia, and subsequently examines its pathogenic mechanisms together with the potential roles and regulatory pathways of the gut microbiota in its alleviation.
Junyu Yang, Jiali Chen, Zhenmin Liu, Yezhi Qu, Xiqing Yue, Bo Yuan, Mohan Li   +6 more
wiley   +1 more source

A depletable pool of adenosine in area CA1 of the rat hippocampus [PDF]

, 2001
Adenosine plays a major modulatory and neuroprotective role in the mammalian CNS. During cerebral metabolic stress, such as hypoxia or ischemia, the increase in extracellular adenosine inhibits excitatory synaptic transmission onto vulnerable neurons via
Caldwell, Darren, Dale, Nicholas, Frenguelli, Bruno G., Nuritova, Feruza, Pearson, Tim   +4 more
core   +1 more source

Mycoplasma hyorhinis‐encoded cytidine deaminase efficiently inactivates cytosine‐based anticancer drugs

FEBS Open Bio, 2015
Mycoplasmas may colonize tumor tissue in patients. The cytostatic activity of gemcitabine was dramatically decreased inMycoplasma hyorhinis‐infected tumor cell cultures compared with non‐infected tumor cell cultures.
Johan Vande Voorde, Peter Vervaeke, Sandra Liekens, Jan Balzarini   +3 more
doaj   +1 more source

Apolipoprotein M (ApoM) Ameliorates Acute Alcohol Intoxication (AAI)‐Hemorrhagic Shock and Resuscitation (HSR)‐Induced Microvascular Leakage

Microcirculation, Volume 32, Issue 7, October 2025.
ABSTRACT Objective Microvascular hyperpermeability is a serious complication that occurs from hemorrhagic shock and resuscitation (HSR), especially when combined with acute alcohol intoxication (AAI). We tested the hypothesis that administration of Apolipoprotein M (ApoM), a lipocalin that normally resides in plasma high‐density lipoproteins (HDL) and ...
Mengmeng Chang, Jerome W. Breslin
wiley   +1 more source

Triazole-Based Compound as a Candidate To Develop Novel Medicines To Treat Toxoplasmosis [PDF]

, 2014
This article reports anti-Toxoplasma gondii activity of 3-(thiophen-2-yl)-1,2,4-triazole-5-thione. The compound displayed significant and reproducible antiparasitic effects at nontoxic concentrations for the host cells, with an experimentally determined
Dzitko, Katarzyna, Paneth, Agata, Paneth, Piotr, Pawełczyk, Jakub, Plech, Tomasz, Węglińska, Lidia   +5 more
core   +1 more source

Metabolic Stress‐Induced Choline Kinase α (CHKA) Activation in Endothelial Subpopulation Contributes to Diabetes‐Associated Microvascular Dysfunction

Advanced Science, Volume 12, Issue 33, September 4, 2025.
This study uncovers CHKA as a pivotal driver of vascular dysfunction in diabetic retinopathy and highlights its role in endothelial dysfunction through NAD⁺‐SIRT1‐Notch signaling. Single‐cell and functional analyses, combined with clinical and genetic validation, suggest CHKA as a promising therapeutic target for the prevention and treatment of ...
Ling Ren, Linyu Zhang, Yun Bai, Chang Huang, Xiaosa Li, Fanfei Ma, Wan Mu, Mudi Yao, Chang Jiang, Xiangjun Chen, Qin Jiang, Biao Yan   +11 more
wiley   +1 more source

Purine nucleoside phosphorylase (PNP) deficiency: across-the-board severe combined immunodeficiency

Egyptian Journal of Medical Human Genetics
Background Purine nucleoside phosphorylase (PNP) deficiency is a rare, autosomal recessive, inborn error of immunity. It is characterized by progressive immune abnormalities ranging from severe combined immunodeficiency (SCID) to combined ...
Engy A. Chohayeb, Sohilla Lotfy, Rabab E. El Hawary, Safa S. Meshaal, Iman A. Mansour, Nermeen M. Galal, Aisha M. Elmarsafy   +6 more
doaj   +1 more source

N‐ to C‐Glycoside Rearrangement of Uridine 5′‐Phosphate in Two Enzymatic Steps for the Production of Pseudouridine 5′‐Phosphate

Biotechnology and Bioengineering, Volume 122, Issue 9, Page 2456-2464, September 2025.
The authors present a streamlined cascade reaction for one‐pot N‐C rearrangement of uridine‐5′‐phosphate (UMP) to pseudouridine‐5′‐phosphate (ΨMP; a key mRNA vaccine building block), in two enzymatic steps catalyzed by UMP nucleosidase (EC 3.2.2.10) and ΨMP C‐glycosidase (EC 4.2.1.70).
Martin Pfeiffer, Franziska Guld, Bernd Nidetzky   +2 more
wiley   +1 more source

Variation in Gene Expression Across Infection Status and Elevation in a Hawaiian Honeycreeper

Ecology and Evolution, Volume 15, Issue 9, September 2025.
Introduced pathogens exert novel selection on hosts, and some hosts have adapted to highly virulent pathogens. We tested for differential gene expression between (i) avian malaria‐infected and ‐uninfected Hawai'i 'amakihi and (ii) low‐ and high‐elevation 'amakihi.
Loren Cassin‐Sackett, Katherine M. McClure, Taylor E. Callicrate, Eben H. Paxton, Robert C. Fleischer   +4 more
wiley   +1 more source

Purine Molecular Interactions Determine Anisotropic Shape of Zebrafish Biogenic Crystals

Small Methods, Volume 9, Issue 9, September 1, 2025.
Many organisms self‐organize crystals for vision, pigmentation, or storage. In zebrafish, iridophores produce anisotropic crystals in iridosomes. Using imaging and genetic tools, crystal growth is shown to favor the b‐axis, shaped by guanine‐to‐hypoxanthine ratios and hydrogen bonding resulting thereof.
Jannik Rothkegel, Sylvia Kaufmann, Michaela Wilsch‐Bräuninger, Catarina Lopes, Rita Mateus   +4 more
wiley   +1 more source