Results 91 to 100 of about 187,335 (337)
Advanced Science, EarlyView.NPR1 induces lipolysis of stored lipid droplet and enhances mitochondrial oxidative phosphorylation to fuel gastric cancer metastasis. Specifically, NPR1‐mediated activation of PKG directly phosphorylates and activates HSL at Ser855 and Ser951, thereby driving lipolytic processes.
Huafeng Fu +15 more
wiley +1 more source
Emerging Role of Purine Metabolizing Enzymes in Brain Function and Tumors
International Journal of Molecular Sciences, 2018 The growing evidence of the involvement of purine compounds in signaling, of nucleotide imbalance in tumorigenesis, the discovery of purinosome and its regulation, cast new light on purine metabolism, indicating that well known biochemical pathways may ...
M. Garcia-Gil +5 more
semanticscholar +1 more source
Advanced Science, EarlyView.HPD is identified as an RNA‐binding protein that promotes mRNA translation by binding to RRACH motifs via its double‐stranded RNA‐binding domains. This RNA‐binding activity critically sustains glycolysis in ovarian cancer cells. Disrupting HPD's RNA‐binding function effectively suppresses tumor growth and enhances therapeutic sensitivity, highlighting ...
Fei Xie +21 more
wiley +1 more source
eLifeCertain strains of a bacterium found in the gut of some animals, Lactobacillus plantarum, are able to counter hyperuricemia, a condition caused by high levels of uric acid in the blood.
Caihong Hu
doaj +1 more source
Autonomic Neuroscience, 2022 The story of purinergic neurotransmission and regulation is intimately linked to studies of the somatosensory system. Burnstock's contributions to the discovery of ATP as a primary afferent neurotransmitter, as well as a signal of peripheral tissue damage that depolarised sensory neurons initiated a new period of pain research.
openaire +4 more sources
High‐Throughput Tiling of Essential mRNAs Increases Potency of Antisense Antibiotics
Advanced Science, Volume 12, Issue 28, July 24, 2025.The systematic tiling of essential genes’ mRNA here presented, proposes a valuable tool for the identification of novel PNA sequences with antibiotic potential. The high‐throughput synthetic set up opens the door to investigating thousands of sequences in an economic way and ultimately identifies potent antisense oligonucleotides while also giving room
Giorgia Danti +3 more
wiley +1 more source
Backbone Protecting Groups for Enhanced Peptide and Protein Synthesis
Angewandte Chemie, EarlyView.This review provides a comprehensive account of the use of backbone N‐protecting groups in peptide synthesis. It includes detailed synthetic methods relating to their introduction and removal and their application to “difficult” peptides and proteins of biological significance in both academic and industry contexts.
Samuel J. Paravizzini +3 more
wiley +2 more sources
Signaling of the Purinergic System in the Joint
Frontiers in Pharmacology, 2020 The joint is a complex anatomical structure consisting of different tissues, each with a particular feature, playing together to give mobility and stability at the body.
Carmen Corciulo +3 more
doaj +1 more source
Abiotic synthesis of purine and pyrimidine ribonucleosides in aqueous microdroplets
Proceedings of the National Academy of Sciences of the United States of America, 2017 Significance Discovery of an improved prebiotic method for the synthesis of ribonucleosides provides support to theories that posit a central role for RNA in the origin of life. It has been assumed that ribonucleosides arose through an abiotic process in
Inho Nam, H. Nam, R. Zare
semanticscholar +1 more source