Results 181 to 190 of about 245,344 (350)

P058: Design of the prospective study of the clinical, laboratory, and dietary determinates of outcomes in purine and pyrimidine metabolism disorders

Genetics in Medicine Open
Shannon Haines, Katharine Chaillet, Oleg Shchelochkov   +2 more
doaj   +1 more source

Nucleotide Metabolic Reprogramming in Sepsis: From Immune-Cell Fate to Organ Injury and Precision Therapeutics

Journal of Inflammation Research
Chun Wang,1 Fu Shuying,1 Jin Jing,2 Fang Fuquan,1 Jie Huang11Department of Anesthesiology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People’s Republic of China; 2Zhejiang Center for Clinical Laboratory ...
Wang C, Shuying F, Jing J, Fuquan F, Huang J   +4 more
doaj  

The distribution and diversity of nucleoside N-deoxyribosyltransferase among lactic acid bacteria [PDF]

Nucleoside N-deoxyribosyltransferases are capable of synthesising stereoand regioselectively a variety of 2'-deoxy- and 2', 3'-dideoxyribonucleosides.
Chawdhri, Rizwana F.
core  

MIT/TFE family transcription factors, Mitf and Tfec, redundantly promote pigment cell differentiation and retinal epithelium pigmentation in teleosts

Developmental Dynamics, EarlyView.
Abstract Background Transcription factors of the MIT/TFE family—mitfa, mitfb, and tfec—play essential roles in specifying pigment cells derived from neural crest cells in vertebrates. In teleosts, which possess multiple pigment cell types, these factors exhibit partially redundant but largely distinct functions across different pigment lineages.
James Lister, Keisuke Sugiwaka, Tetsuaki Kimura, Rieko Tanaka, Makoto Goda, Hikaru Kobayashi, Chikako Inoue, Kawilarang W. A. Masengi, Kazunori Yamahira, Kiyoshi Naruse, Satoshi Ansai, Robert N. Kelsh, Masahiko Hibi, Hisashi Hashimoto   +13 more
wiley   +1 more source

Metabolic abnormalities and reprogramming in cats with naturally occurring hypertrophic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1256-1270, April 2025.
Abstract Background and aims The heart is a metabolic organ rich in mitochondria. The failing heart reprograms to utilize different energy substrates, which increase its oxygen consumption. These adaptive changes contribute to increased oxidative stress.
Qinghong Li, Max Homilius, Erin Achilles, Laura K. Massey, Victoria Convey, Åsa Ohlsson, Ingrid Ljungvall, Jens Häggström, Brittany Vester Boler, Pascal Steiner, Sharlene Day, Calum A. MacRae, Mark A. Oyama   +12 more
wiley   +1 more source

Regioselective Nucleophilic Aromatic Substitution of 2,6-Bis-(1,2,3-Triazolyl)-Purine Derivatives with Various Nucleophiles

A novel class of bis-triazolyl purine nucleosides were obtained from 2,6-diazido precursors via copper (I) catalyzed azide-alkyne cycloaddition. These intermediates appeared to be very reactive towards N- and S-nucleophiles and thus selectively gave C(6)-
Bizdēna, Ērika, Novosjolova, Irina, Turks, Māris   +2 more
core  

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

Efficient Synthesis of 6-Amino-2-triazolyl Purine Arabinonucleosides via 2,6-Ditriazolyl Derivatives and Fluorescent Properties Thereof

This abstract shows the synthesis of 2,6-bistriazolyl purine derivatives via "click" reaction and the use of obtained ...
Bizdēna, Ērika, Novosjolova, Irina, Kovaļovs, Armands, Turks, Māris   +3 more
core  

System‐Local Axes and Metabolic Reprogramming From Health to Response in House Dust Mite‐Specific Subcutaneous Immunotherapy for Allergic Rhinitis

iMetaMed, EarlyView.
This study delineated nasal‐plasma metabolic reprogramming in house dust mite‐allergic rhinitis (HDM‐AR) and subcutaneous immunotherapy (SCIT) response, showing compartment‐specific signatures dominated by nasal lipid‐redox and plasma nucleotide‐NAD+ axes and across the HC–HDM‐AR–SCIT response continuum, dual‑compartment metabolites exhibited ...
Bixing Fang, Fei Pan, Yachun Li, Yimeng Wang, Ze Wang, Zhiheng Huang, Ming Chen, Yun Li, Mengli Huang, Cheng Guo, Chubo Xie, Lina Dong, Yadong Gao, Zhuohang Yu   +13 more
wiley   +1 more source

Targeted analysis of purine derivatives in beer and fermented beverages using HPLC-QDA. [PDF]

Food Chem X
Sen R, Schubert C, Rani H, Lafontaine S.
europepmc   +1 more source