Results 201 to 210 of about 157,697 (307)

Screening of purine nucleoside analogues against intracellular Toxoplasma gondii. [PDF]

Int J Parasitol Drugs Drug Resist
Elati HAA, Van Calenbergh S, Sheiner L, de Koning HP.   +3 more
europepmc   +1 more source

Salivary uric acid remote serial self‐testing for prediction of adverse pregnancy outcomes of uteroplacental dysfunction

Acta Obstetricia et Gynecologica Scandinavica, EarlyView.
Remote, weekly self‐testing of salivary uric acid enables longitudinal monitoring throughout pregnancy. RGB‐derived measurements are combined with maternal characteristics in a model using 4 weeks of prior data. This approach provides individualized prediction of hypertensive disorders of pregnancy and fetal growth restriction within 1 week.
Basia Chmielewska, Chao Wang, Nick Macklon, Amar Bhide, Basky Thilaganathan   +4 more
wiley   +1 more source

Microcephaly-associated protein WDR62 supports purine metabolism by interacting with co-chaperone BAG2. [PDF]

EMBO J
Morris MJ, Yeap YY, Edwards JR, Chen C, Paolino A, Furness SGB, Millard SS, Pagan JK, Fenlon LR, Ng DCH.   +9 more
europepmc   +1 more source

The potential for biased signalling in the P2Y receptor family of GPCRs

British Journal of Pharmacology, EarlyView.
The purinergic receptor family is primarily activated by nucleotides, and contains members of both the G protein coupled‐receptor (GPCR) superfamily (P1 and P2Y) and ligand‐gated ion channels (P2X). The P2Y receptors are widely expressed in the human body, and given the ubiquitous nature of nucleotides, purinergic signalling is involved with a plethora
Claudia M. Sisk, Simon Pitchford, Graham Ladds   +2 more
wiley   +1 more source

Chemical Modification of 2,6,9-Trisubstituted Purine CDK Inhibitors: <i>tert</i>-Butylation at <i>N</i>7/<i>N</i>9 and Access to 2,6,7-Trisubstituted Analogs. [PDF]

ACS Omega
Valenta M, Stýskala J.
europepmc   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Structural Basis for Nucleobase Activation by the Adenine DNA Glycosylase MutY. [PDF]

Chembiochem
Russelburg LP, Demir M, Cedeno K, David SS, Horvath MP.   +4 more
europepmc   +1 more source

Refining the treatment of immune checkpoint inhibitor–associated myocarditis: Challenges, innovations and rechallenge considerations

British Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitor (ICI)‐associated myocarditis has emerged as a severe and clinically complex immune‐related toxicity that poses significant challenges for therapeutic decision‐making in routine cardio‐oncological care. High‐dose corticosteroids remain the first‐line therapy, yet their timing, dosage and tapering require careful clinical ...
Raluca I. Mincu, Lisa Zimmer, Dimitra Vlachopoulou, Elias Haj‐Yehia, Julia Hoffmann, Lars Michel, Elisabeth Livingstone, Dirk Schadendorf, Alpaslan Tasdogan, Matthias Totzeck, Tienush Rassaf   +10 more
wiley   +1 more source

Biomimetic Studies on the Reactivity of Sulfur-Centered Radicals with Purine Moieties of DNA. [PDF]

Biomolecules
Masi A, Barata-Vallejo S, Chatgilialoglu C.   +2 more
europepmc   +1 more source

Aspartate Transporter SLC1A3 Promotes Colorectal Cancer via MDM2‐p53 Pathway and M2 Macrophage Polarization

Cancer Science, EarlyView.
SLC1A3 promotes colorectal cancer progression by transporting extracellular aspartate into tumor cells, thereby activating the PKC/MDM2/p53 pathway to enhance proliferation. Reduced extracellular aspartate, combined with p53‐dependent suppression of CSF2 and IL17C, drives M2 macrophage polarization via immune modulation, macrophage recruitment, and M2 ...
Chao Deng, You Zhou, Sijie Song, Hongtao Liu, Siqi Liao, Li Zhou, Siyuan Chen, Zhihang Zhou, Song He, Bingrong Liu   +9 more
wiley   +1 more source