Results 201 to 210 of about 134,014 (261)

Post‐Transplant Bendamustine as a Platform for Immune Modulation After Allogeneic Hematopoietic Cell Transplantation

European Journal of Haematology, EarlyView.
ABSTRACT Post‐transplant cyclophosphamide (PT‐CY) remains the standard of care for graft‐versus‐host disease (GvHD) prophylaxis in haploidentical hematopoietic cell transplantation (HCT), yet relapse, delayed immune reconstitution, infections, and organ toxicity represent persistent and clinically meaningful limitations.
Megan J. Cracchiolo, Richard J. Simpson, Emmanuel Katsanis   +2 more
wiley   +1 more source

Metabolic reconstruction reveals ATP salvage as a key response to trimethoprim treatment. [PDF]

iScience
Carter C, Singh D, Wain J, Langridge GC.
europepmc   +1 more source

Contrasting effects of different molecular crowding environments on base‐pair opening/closing dynamics of DNA triplex structures

The FEBS Journal, EarlyView.
Base‐pair opening and closing regulate nucleic‐acid structure, stability, and function, but how these motions behave under intracellular molecular crowding remains unclear. Using NMR, we quantified these dynamics in a DNA triplex under two crowder‐reconstituted environments that mimic cellular crowding.
Tomoki Sakamoto, Yudai Yamaoki, Takashi Nagata, Masato Katahira   +3 more
wiley   +1 more source

Integrated transcriptomic and metabolomic analysis identifies C5NT1AL as a candidate gene influencing inosine monophosphate levels in chicken breast muscle. [PDF]

Poult Sci
Yang H, Liu L, Wang Y, Wang Y, Zhuang J, Cui H, Zhao G, Wen J.   +7 more
europepmc   +1 more source

Transgenic selection and underlying mechanisms in apicomplexan parasites

The FEBS Journal, EarlyView.
Transgenic selection markers have driven genetic engineering in apicomplexans, enabling precise, iterative experiments. This review discusses mechanistic details of drug selection markers, strategies for marker recycling, and practical considerations for several clinically relevant parasites.
Swaroop Peddiraju, Rakhee Lohia, Nishith Gupta   +2 more
wiley   +1 more source

Oral supplementation of <i>Pediococcus pentosaceus</i> SMM847 ameliorates hyperuricemia in rats and alcohol-induced injury in mice. [PDF]

Appl Environ Microbiol
Cao Y, Wang L, Ren C, Li C, Liu Y, Zhang T, Luo M, Zhao P, Li R, Fu J, Yin J.   +10 more
europepmc   +1 more source

From hepatic to hematopoietic: LRH‐1's expanding cellular repertoire to the immune system

The FEBS Journal, EarlyView.
The nuclear receptor LRH‐1 is a well‐characterized regulator of endodermal tissue. Yet, increasing evidence indicates that LRH‐1, although expressed at low levels, is also a critical regulator of the hematopoietic system. LRH‐1 regulates the immune system by contributing to immune cell‐specific functions.
Lukas Meisinger, Alice Wiedmann, Rayan Hassan M. Elshikhidriss, Thomas Brunner   +3 more
wiley   +1 more source

Editorial: The pharmacological effects and mechanisms of drugs against human diseases by modulating redox homeostasis, volume III. [PDF]

Front Pharmacol
Zhang X, Cui X, Xu M.
europepmc   +1 more source

Structural basis for allosteric regulation of mycobacterial guanosine 5´-monophosphate reductase by ATP and GTP. [PDF]

Nat Commun
Doležal M, Knejzlík Z, Kouba T, Filimoněnko A, Šváchová H, Dedola M, Klíma M, Pichová I.   +7 more
europepmc   +1 more source

Warfarin-Durian interaction: A case study bridging clinical outcomes and metabolic profiling through metabolomics. [PDF]

Toxicol Rep
Hiranchatchawal N, Wannaphueak K, Rattanasuwan P, Lertpongpipat P, Konguthaithip G, Jaikang C, Tajai P.   +6 more
europepmc   +1 more source