Results 221 to 230 of about 148,463 (294)

The extracellular matrix drives guanylate production and protects pancreatic cancer cells from oxaliplatin-induced DNA damage. [PDF]

Sci Adv
Efthymiou G, Lohmann E, Montenegro C, Kousteridou P, Bertrand P, Pereira J, Carr HS, Ben-Sahra I, Compare C, Nemazanyy I, Bidaut G, Finetti P, Bertucci F, Lachaud C, Guillaumond F, Tomasini R, Vasseur S.   +16 more
europepmc   +1 more source

On why cancer cells require a great amount of glucose

Quantitative Biology, Volume 14, Issue 2, June 2026.
Abstract The traditional thinking has been that cancer cells require a great amount of glucose to support their rapid growth, but the reality may be different. We have previously demonstrated that all cancer cells in The Cancer Genome Atlas harbor persistent Fenton reactions in their cytosol, which generate OH− ${\text{OH}}^{-}$ and ultimately kill the
Xuechen Mu, Aoran Liu, Rui Shi, Long Xu, Zhenyu Huang, Ye Zhang, Ying Xu   +6 more
wiley   +1 more source

Purine metabolism: a pan-cancer metabolic dysregulation across circulation and tissues. [PDF]

Mol Cancer
Yu M, Liu C, Cao M, Yang D, Wang T, Xu J, Zhu D, Wang G, Aa J, Zhu W.   +9 more
europepmc   +1 more source

Metabolic‐immune interactions in gastric cancer T cells: A single‐cell atlas for prognostic biomarker identification

Quantitative Biology, Volume 14, Issue 2, June 2026.
Abstract Metabolic alterations and immune dysfunction within the gastric tumor microenvironment critically drive gastric cancer (GC) progression and therapeutic resistance. Although single‐cell RNA sequencing (scRNA‐seq) has unveiled cellular heterogeneity in GC, the metabolic landscapes of tumor cells and their interplay with immune components remain ...
Junjun Liu, Rui Zhao, Guodong Yao, Zhao Liu, Runze Shi, Jingshu Geng, Guanying Liang, Kexin Chen   +7 more
wiley   +1 more source

Digital twins for in vivo metabolic flux estimations in patients with brain cancer. [PDF]

Cell Metab
Meghdadi B, Al-Holou WN, Scott AJ, Mittal A, Liang N, Sravya P, Achreja A, O'Brien A, Do K, Wu Z, Feng J, Qi NR, Tarnal V, Venneti S, Miller CR, Sarkaria JN, Zhou W, Lawrence TS, Lyssiotis CA, Wahl DR, Nagrath D.   +20 more
europepmc   +1 more source

Prodrugs of purine and pyrimidine analogues for the intestinal di/tri-peptide transporter PepT1: affinity for hPepT1 in Caco-2 cells, drug release in aqueous media and in vitro metabolism

, 2003
Anne Engelbrecht Thomsen, Gerda Marie Friedrichsen, Arne Hagsten Sørensen, Rikke Andersen, Carsten Uhd Nielsen, Birger Brodin, Mikael Begtrup, Sven Frøkjær, Bente Steffansen   +8 more
openalex   +1 more source

Decreased purine ingestion, increased molybdenum ingestion, and the decline in amyotrophic lateral sclerosis on Guam. [PDF]

Front Nutr
Bourke CA.
europepmc   +1 more source

Radiation Damage of Purines and Pyrimidines (Special Issue on Physical, Chemical and Biological Effects of Gamma Radiation, IX)

, 1968
Saburo MATSUOKA
openalex   +1 more source

An Overview of Liquid Chromatography–Mass Spectrometry (LC–MS) Methods for the Quantification of Antibody‐Drug Conjugates

Biomedical Chromatography, Volume 40, Issue 2, February 2026.
ABSTRACT Antibody‐drug conjugates (ADCs) are innovative drugs composed of cytotoxic molecules (payload) linked to antibodies, that selectively target and kill cancer cells upon internalization. In vivo, ADCs exist as intact molecules, naked antibodies, or released, unconjugated (linker‐)payload.
Pauline L. M. Buitelaar, Hilde Rosing, Jos H. Beijnen, Neeltje Steeghs, Alwin D. R. Huitema   +4 more
wiley   +1 more source

Temozolomide-Derived AIC Is Incorporated into Purine Synthesis in Glioblastoma. [PDF]

Chem Res Toxicol
Sowers ML, Baljinnyam T, Herring JL, Chang-Gu B, Hackfeld LC, Tang H, Hatch S, Valdes P, Zhang K, Sowers LC.   +9 more
europepmc   +1 more source