Results 221 to 230 of about 209,598 (340)

Purine Nucleoside Phosphorylase Inhibition Rebalances Purine Metabolism and Attenuates Organ Damage in Sickle Cell Mice. [PDF]

J Cell Mol Med
Alagbe AE, Little-Ihrig L, Mutchler SM, Jackson EK, Novelli EM, Tofovic SP.   +5 more
europepmc   +1 more source

Metabolic and neurobehavioral disturbances induced by purine recycling deficiency in Drosophila

Céline Petitgas, Laurent Seugnet, Amina Dulac, Giorgio Matassi, Ali Mteyrek, Rebecca Fima, Marion Strehaiano, Joana Dagorret, Baya Chérif‐Zahar, Sandrine Marie, Irène Ceballos-Picot, Serge Birman   +11 more
openalex   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

One-Carbon Metabolism and Midbrain Dopaminergic Cells in Lesch-Nyhan Disease. [PDF]

Mol Syndromol
Alsuwaidi S, Ernst C.
europepmc   +1 more source

Immunodeficiency, Motor Delay, and Hypouricemia Caused by a Novel Mutation of Purine Nucleoside Phosphorylase Gene in an Indian Infant

, 2018
Nikit Shah, Lokesh Lingappa, Ramesh Konanki, Sirisha Rani, Vedam L. Ramprasad, Sakthivel Murugan   +5 more
openalex   +1 more source

Songorine inhibits mitophagy in chronic heart failure via the TBC1D15/Fis1/Rab7A pathway

British Journal of Pharmacology, EarlyView.
Abstract Background and purpose Songorine (SGR) is an alkaloid extracted from Aconitum carichaelii Debx. and has a demonstrated role in cardiac dysfunction. Chronic heart failure (CHF) is a severe clinical syndrome leading to functional impairment and death, primarily due to the deterioration of energy metabolism in cardiomyocytes. However, the precise
Wenxiu Liu, Xingju Zou, Yang Zheng, Chen Sun, Cheng Peng   +4 more
wiley   +1 more source

Exploration of purine metabolism-related genes in the development of osteoporosis by integrated analyses and experiments. [PDF]

Eur J Med Res
Zeng Y, Hu J, Lu J, Zhu Y.
europepmc   +1 more source

Studies of Nucleosides and Nucleotides. XXXII. Purine Cyclonucleosides. 3. Synthesis of 2'-Deoxy- and 3'-Deoxyadenosine from Adenosine

, 1967
Morio Ikehara, Hiroshi Tada
openalex   +2 more sources

Fluorescent properties of an unnatural nucleobase, 2-amino-6-(2-thienyl)purine, in DNA and RNA fragments [PDF]

, 2005
Tsuneo Mitsui, Michiko Kimoto, Shigeyuki Yokoyama, Ichiro Hirao   +3 more
openalex   +1 more source

Purine‐related metabolites and their converting enzymes are altered in frontal, parietal and temporal cortex at early stages of Alzheimer's disease pathology

Brain Pathology, 2018
Patricia Alonso-Andrés, J. L. Albasanz, I. Ferrer, Mairena Martín   +3 more
semanticscholar   +1 more source