Results 251 to 260 of about 311,690 (329)

Synergistic effect of ZIF‐8 nanomaterial on 2,4‐D efficacy by regulating auxin synthesis pathway in barnyard grass [Echinochloa crus‐galli (L.) P. Beauv.]

New Plant Protection, EarlyView.
ZIF‐8 exhibited a synergistic effect on 2,4‐D efficacy against barnyard grass by regulation of auxin synthesis pathway, as well as the synergistic regulation of metabolic pathways involving 2,4‐D and ZIF‐8. Furthermore, the use of ZIF‐8 as a carrier could improve the safety of 2,4‐D for wheat.
Runze Cai, Yujiao Jia, Qiliang Huang, Xile Deng, Lidong Cao, Pengyue Zhao, Canping Pan   +6 more
wiley   +1 more source

Allopurinol Treatment Improves Cognitive Skills, Adaptive Behavior, and Biochemical Markers in Young Patients With Adenylosuccinate Lyase Deficiency. [PDF]

J Inherit Metab Dis
Rousselot-Pailley B, Semeraro M, Marquant F, Robel L, Gitiaux C, Kaminska A, Mochel F, Bakouboula P, Elie C, Hennequin C, Ceballos-Picot I, Sanquer S, de Lonlay P.   +12 more
europepmc   +1 more source

Multidirectional in silico and in vitro Research for the Pharmaceutical Potential of Fibigia Clypeata (L.) Medik: Phytochemical, Antimicrobial, and Antimyeloma Properties

ChemistryOpen, EarlyView.
Fibigia clypeata water extract has a slightly more substantial inhibitory effect than the methanol extract. F. clypeata decreased cell viability in three human MM cells and the MCF10A cell lines. Cyanidin 3‐rutinoside chloride has the highest binding affinity to Staphylococcus aureus MurB, Candida parapsilosis, and Candida albicans dihydrofolate ...
Tuba Unver, Ugur Uzuner, Dilara Akcora‐Yildiz, Ismet Gurhan, Caglar Arkan, Zeynep Ozdemir   +5 more
wiley   +1 more source

Strategies to reduce uric acid through gut microbiota intervention. [PDF]

Front Microbiol
Cui Y, An P, Li F, Duan F, Mei Z, Ye Q, Wang G, Zhang H, Luo Y.   +8 more
europepmc   +1 more source

Design, Synthesis, Cytotoxicity Assessment, and Molecular Docking of Novel Triazolopyrimidines as Potent Cyclin‐Dependent Kinase 4 Inhibitors

ChemistryOpen, EarlyView.
A novel series of 1,5‐dihydro‐[1,2,4]triazolo[4,3‐a]pyrimidines (5a–g) is synthesized and evaluated as potential CDK4 inhibitors. Compounds 5c and 5d exhibit strong cytotoxicity toward HepG2 and MCF‐7 cells with IC50 ≈ 1–2 µM, comparable to doxorubicin.
Tariq Z. Abolibda, Sami A. Al‐Hussain, Basant Farag, Mohamed El‐Naggar, Magdi E. A. Zaki, Emad S. A. Alhazmi, Adel S. M. Almohammadi, Sobhi M. Gomha   +7 more
wiley   +1 more source

Mining Alzheimer's Interactomes, Macromolecular Complexes and Pathways for Drug Discovery

PROTEOMICS, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a progressive neurodegenerative disorder that leads to dementia. Many cases are diagnosed annually and there is no currently available cure. Understanding the underlying disease biology of AD through the study of molecular networks, particularly by mapping clinical variants to tissue‐specific interactomes and ...
Kalpana Panneerselvam, Krishna Kumar Tiwari, Luana Licata, Simona Panni, Sylvie Ricard‐Blum, Sucharitha Balu, Susie Huget, Juan Jose Medina Reyes, Eliot Ragueneau, Livia Perfetto, Birgit Meldal, Sandra Orchard, Henning Hermjakob   +12 more
wiley   +1 more source

Benzoxazine-Purine Hybrids as Antiproliferative Agents: Rational Design and Divergent Mechanisms of Action. [PDF]

Pharmaceutics
Boulaiz H, Jiménez-Martínez Y, Franco-Montalbán F, Peña-Martín J, Conejo-García A, Carrión MD.   +5 more
europepmc   +1 more source

Functional Relevance of CASP16 Nucleic Acid Predictions as Evaluated by Structure Providers

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Accurate biomolecular structure prediction enables the prediction of mutational effects, the speculation of function based on predicted structural homology, the analysis of ligand binding modes, experimental model building, and many other applications.
Rachael C. Kretsch, Reinhard Albrecht, Ebbe S. Andersen, Hsuan‐Ai Chen, Wah Chiu, Rhiju Das, Jeanine G. Gezelle, Marcus D. Hartmann, Claudia Höbartner, Yimin Hu, Shekhar Jadhav, Philip E. Johnson, Christopher P. Jones, Deepak Koirala, Emil L. Kristoffersen, Eric Largy, Anna Lewicka, Cameron D. Mackereth, Marco Marcia, Michela Nigro, Manju Ojha, Joseph A. Piccirilli, Phoebe A. Rice, Heewhan Shin, Anna‐Lena Steckelberg, Zhaoming Su, Yoshita Srivastava, Liu Wang, Yuan Wu, Jiahao Xie, Nikolaj H. Zwergius, John Moult, Andriy Kryshtafovych   +32 more
wiley   +1 more source

Molecular interplay between TXNIP and GLUT9 underlies uric acid transport dysregulation in vitro under hyperuricemic stress. [PDF]

Eur J Med Res
Zhu Y, Zhang B, He Y, Du M, Chen W, Chen X, Yang Q, Kahaer M, Sun Y.   +8 more
europepmc   +1 more source

Comparative lipidomic and proteomic analysis reveals species‐specific differences in midgut composition and insecticide absorption between Apis mellifera and Bombus terrestris

Pest Management Science, EarlyView.
Lipidomic and proteomic analysis revealed large‐scale differences in the midgut composition of the honeybee Apis mellifera and the buff‐tailed bumblebee Bombus terrestris. These differences correlated to increased insecticide absorption in the bumblebee when using an ex vivo Ussing chamber and subsequently in vivo feeding assay (created in Biorender ...
Emmanouil Kokkas, Joseph Hawkins, Lauraine Swindale, Aniko Kende, John Sinclair, Jacob M Riveron, Helen Thompson, Adam Pym   +7 more
wiley   +1 more source