Results 271 to 280 of about 245,344 (350)

Serum uric acid in pediatric metabolic assessment: the scientific rationale for routine screening and the urgent need for age- and sex-specific diagnostic thresholds. [PDF]

Front Nephrol
Salomon I, Ndamukunda Y, Solange M, Zeleke EE.   +3 more
europepmc   +1 more source

Triangulating Evidence on Serum Uric Acid and Cancer Risk: Consistent Inverse Associations With Lung Cancer

Cancer Science, EarlyView.
Using both conventional observational and Mendelian randomization (MR) analyses in the same Japanese community‐dwelling population, the evidence consistently supported an inverse association between the serum uric acid level and lung cancer risk. ABSTRACT We examined the association between serum uric acid (UA) levels and cancer incidence through a ...
Takashi Matsunaga, Kenji Wakai, Takashi Tamura, Mako Nagayoshi, Rieko Okada, Itsuki Kageyama, Megumi Hara, Takuma Furukawa, Hiroaki Ikezaki, Yuji Matsumoto, Takeshi Nishiyama, Hiroko Nakagawa‐Senda, Chihaya Koriyama, Shiroh Tanoue, Naoyuki Takashima, Etsuko Ozaki, Katsuyuki Miura, Aya Kadota, Takeshi Watanabe, Masashi Ishizu, Kiyonori Kuriki, Masahiro Nakatochi, Yukihide Momozawa, Issei Imoto, Isao Oze, Keitaro Matsuo, the J‐MICC Study Group   +26 more
wiley   +1 more source

The EBNA-1 Conundrum: Does Epstein-Barr Virus Invoke Autoimmune Pathology in a Population Subset by Poorly Purine-Loading Its Major Latency-Maintaining Transcript? [PDF]

Scand J Immunol
Forsdyke DR.
europepmc   +1 more source

Multi‐Omics Integration Reveals Metabolic Reprogramming and EMT‐Driven Metastasis in Triple‐Negative Breast Cancer

Cancer Science, EarlyView.
Integrated transcriptomic, metabolomic, and spatial proteomic profiling of TNBC tumors identifies a metastatic‐associated molecular landscape characterized by EMT activation, metabolic reprogramming, and tumor microenvironment (TME) remodeling. Multi‐omics integration reveals coordinated alterations in EMT signatures, amino acid metabolism, immune ...
Yuheng Pang, Yuefeng Shang, Wenjing Wang, Tong Liu, Xiaolong Zou   +4 more
wiley   +1 more source

PAICS mediates DNA damage and cerebellar neuronal loss in C9orf72 amyotrophic lateral sclerosis. [PDF]

Brain
Singh J, Lescouzères L, Zaouter C, Chaineau M, Haghi G, Durcan TM, Patten SA.   +6 more
europepmc   +1 more source

Dietary Leucine Restriction Suppresses Platelet‐Driven HCC Growth by Attenuating mTOR Signaling

Cancer Science, EarlyView.
Platelets induce leucine accumulation in HCC cells. In vitro, leucine deprivation or S6K1 inhibition with PF‐4708671 suppresses platelet‐promoted proliferation, migration, and invasion. In vivo, dietary leucine restriction reduces tumor growth following platelet pre‐incubation.
Xeulian Ruan, Guiyong Ou, Cuiju Mo, Yi Zhang, Shanzi Qin, Yongling Chen, Dan Li, Liuying Nie, Li Xie, Zuojian Hu   +9 more
wiley   +1 more source

Ammonia Accumulation Drives Intervertebral Disc Degeneration by Triggering Ammonia‐Induced Cell Death Through Lysosome–Mitochondria Crosstalk

Cell Proliferation, EarlyView.
Mechanical strain disrupts the lysosome‐mitochondria axis via GLS1‐mediated ammonia toxicity, causing NP cell death and ECM breakdown in IVDD. CB839‐mediated GLS1 inhibition effectively rescues cellular homeostasis and alleviates disc degeneration.
Yang Zhang, Yucheng Gao, Shuhang Dong, Shuanggong Liu, Lei Liu, Ziyi Song, Jie Xu, Yijun Rong, Guangxu Song, Yingze Zhang, Dongjin Wu, Zengxin Gao   +11 more
wiley   +1 more source

Purine-Metabolism Reprogramming Associated with Failed-Repair Proximal Tubule States in the AKI-to-CKD Transition. [PDF]

Metabolites
Zhang J, Song K, Han W, Wang Z, Cao G.
europepmc   +1 more source

Multimodal Exploratory Analysis of Persistent Diabetic Macular Edema: Integrating Aqueous Humour Metabolomics, Clinical and OCT Features

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Purpose This exploratory study integrates aqueous humour metabolomic data with clinical and imaging features to examine candidate biomarkers and characterize multimodal patterns associated with persistent diabetic macular edema (pDME). Methods In this prospective cohort study, DME patients were treated with monthly anti‐VEGF injections over 3 ...
Yunhan Tao, Huimin Yu, Yunxi Ma, Mingzhu Yuan, Guochong Chen, Jun Liu, Xi Chen, Xufang Sun   +7 more
wiley   +1 more source

Integrated transcriptomics and metabolomics reveal suppression of the PPAR α/γ pathway linking purine metabolism disorder to high-protein diet-induced hyperuricemia in goslings. [PDF]

Anim Nutr
Li X, Xie Y, Zhang M, Zou T, Zhong C, Rajput ZI, Bi S, Cao L.   +7 more
europepmc   +1 more source