Results 271 to 280 of about 311,690 (329)

Purine Biosynthesis Metabolically Constrains Intracellular Survival of Uropathogenic Escherichia coli

Infection and Immunity, 2016
C. Shaffer, Ellisa W. Zhang, A. Dudley, B. Dixon, Kirsten R. Guckes, Erin J. Breland, K. A. Floyd, D. Casella, H. Algood, D. Clayton, M. Hadjifrangiskou   +10 more
semanticscholar   +1 more source

Integrated multi‐biofluid extracellular vesicle isolation with dual‐platform mass spectrometry metabolomics for prostate cancer detection

VIEW, EarlyView.
Abstract Prostate cancer poses a significant clinical challenge due to limited screening methods and incomplete understanding of its metabolic rewiring. Extracellular vesicles (EVs) carry bioactive metabolites that mirror tumor biology, enabling mechanistic study and biomarker discovery.
Chengbang Wang, Xueying Chen, Xuhong Zhang, Xianqi Shen, Haisong Tan, Yanbo Chen, Shaohua Chen, Shilong Liu, Xu Gao, Fubo Wang, Shunxiang Li, Bin Xu   +11 more
wiley   +1 more source

Peptide nucleic acid biosensors: Structure–interface interactions, electrochemical signal strategies, and diagnostic applications

VIEW, EarlyView.
This review discusses the structural and functional properties of peptide nucleic acid (PNA)‐based biosensors, emphasizing their sensitivity, enzymatic resistance, and diagnostic potential. It presents a comparative analysis of detection limits across sensor designs, focusing on probe immobilization, electrode composition, and signal amplification. The
Younghwan Kim, Swomitra Kumar Mohanty
wiley   +1 more source

Bionic nanobombs target nasopharyngeal carcinoma to enhance the efficacy of chemoradiotherapy by destroying DNA damage repair systems

VIEW, EarlyView.
A bionic nanomedicine system with core–shell structure (Nm‐pAu/CP/KU) was constructed. PEGylated gold nanoparticles (pAu) were loaded with cisplatin (CP) and a radiochemotherapy sensitizer (KU‐60019) to form the core pAu/CP/KU, and homologous nasopharyngeal carcinoma cell membrane vesicles (Nm) were used as the shell.
Junhua Zhang, Xinying Xiang, Xinmin Nie, Jian Li, Rong Gui   +4 more
wiley   +1 more source

Comparison of Three Sympatric Desert Lizards: Digestive Tract Structure, Digestive Enzyme Activities, Gut Microbiota, and Metabolites

Integrative Zoology, EarlyView.
We performed 16S rDNA sequencing and metabolite profiling for three sympatric lizard species—Teratoscincus roborowskii, Phrynocephalus axillaris, and Eremias roborowskii—and compared their goblet cell and enzyme activities in the digestive tract. Our study suggests that the dietary niche may promote divergence or convergence of microbiota across host ...
Yi Yang, Ziyi Wang, Ruichen Wu
wiley   +1 more source

The Success of Newborn Screening Beyond War: An International Collaborative Case of Purine Nucleoside Phosphorylase (PNP) Deficiency. [PDF]

Int J Neonatal Screen
Bettiol A, Damiano R, Mytsyk N, Samonenko N, Cericola G, Speckmann C, Olkhovich N, Guerrini R, la Marca G.   +8 more
europepmc   +1 more source

Comparative in vitro studies on the immunosuppressive effects of purine and pyrimidine synthesis inhibitors. [PDF]

, 1993
Duquesnoy, RJ, Fung, JJ, Starzl, TE, Todo, S, Venkataramanan, R, Yao, GZ, Zeevi, A   +6 more
core  

Inhibition of histamine release by purine and pyrimidine derivatives

, 1982
Kazuhiro Shimamura, Masahiro Nishibori, Hiroshi Yokoyama, Kohji Tsutsumi, Kiyomi Saeki   +4 more
openalex   +1 more source

The Human Cardiac “Age‐OME”: Age‐Specific Changes in Myocardial Molecular Expression

Aging Cell, EarlyView.
A multi‐omics analysis was performed to uncover the molecular landscape of human cardiac ageing. We report several insights for the first time: a decrease in proteins composing the structural machinery of the heart; a likely compensatory increase in energetic flux and redox reductive capacity; and an increase in lysosomal activity.
Cassandra Malecki, Giovanni Guglielmi, Benjamin Hunter, Dylan Harney, Yen Chin Koay, Anthony. S. Don, Oscar Han, Jasmine Khor, Lisa Nguyen, Michael Pan, Peter Gawthrop, Nathan Isles, Joshua Chung, Robert. D. Hume, Matthew Taper, XiaoSuo Wang, Mark Larance, Fabian Spill, Vijay Rajagopal, John F. O’Sullivan, Sean Lal   +20 more
wiley   +1 more source

Using BONCAT to dissect the proteome of <i>S. aureus</i> persisters. [PDF]

mSphere
George Matlalcuatzi EDC, Bakkum T, Thomas PS, Hacker S, Florea BI, Vriesendorp B, Rozen DE, van Kasteren SI.   +7 more
europepmc   +1 more source