Results 41 to 50 of about 186,546 (339)

Rules governing the genetic code degeneracy/redundancy and spatial organization of the codon informative properties

Frontiers in Applied Mathematics and Statistics
The present study is devoted to describing the “logic” implicit in the standard genetic code. Bases are considered as physicochemical entities possessing two essential properties: molecular type and number of Hydrogen bonds involved (bases pairing) in ...
Melina Rapacioli, Melina Rapacioli, Ricardo Katz, Vladimir Flores, Vladimir Flores   +4 more
doaj   +1 more source

Synthesis a Number of Triazene Compounds Derived From Purine and Studying their Biological Activity on Pathogenic Bacteria [PDF]

مجلة جامعة الانبار للعلوم الصرفة, 2012
In this research a number of compounds were prepared by coupling dizonium salts with purine bases. The structures of the prepared compounds were identified by ultra violet ,infra red spectra and Elemental (C.H.N) analysis .The biological activity of ...
Ahmed .M. Mohamed, Hameed H.Ali, Yousif. H. Khalaf   +2 more
doaj   +1 more source

Identifying prognostic targets in metastatic prostate cancer beyond AR

FEBS Open Bio, EarlyView.
Genome‐wide functional screens combined with a large gene expression database and clinical outcomes can identify new therapeutic vulnerabilities in prostate cancer. Eight potentially druggable targets demonstrated strong dependency in cell lines, were associated with worse prognosis clinically, and showed evidence of protein expression in prostate ...
Emily Feng, Eric Feng, Tracy Berg, Isabella S. Nguyen, Lilac G. Nguyen, William Chen, Meng Zhang, David Quigley, Marina Sharifi, Haolong Li, Ilsa Coleman, Peter S. Nelson, Martin Sjöström, Shuang G. Zhao   +13 more
wiley   +1 more source

The Key Role of Purine Metabolism in the Folate-Dependent Phenotype of Autism Spectrum Disorders: An In Silico Analysis

Metabolites, 2020
Folate deficiency in the critical developmental period has been repeatedly associated with an increased risk of Autism spectrum disorders (ASD), but the key pathophysiological mechanism has not yet been identified. In this work, we focused on identifying
Jan Geryk, Daniel Krsička, Markéta Vlčková, Markéta Havlovicová, Milan Macek, Radka Kremlíková Pourová   +5 more
doaj   +1 more source

Interaction of Oligonucleotides with Gold Nanoparticles: Factors Beyond Electrostatic and Van‐Der Waals Forces

Advanced Materials Interfaces, EarlyView.
The formation of stable clusters of gold nanoparticles with oligonucleotides at different solution conditions is explored. DNA base homogeneity and strand directionality influence the binding with gold nanoparticles leading to interesting clustering behavior that can be relevant for SERS applications.
Shaila Thakur, Nicola Cavallini, Debora Ferrari, Laura Fabris   +3 more
wiley   +1 more source

Efficient Synthesis of α-Branched Purine-Based Acyclic Nucleosides: Scopes and Limitations of the Method

Molecules, 2020
An efficient route to acylated acyclic nucleosides containing a branched hemiaminal ether moiety is reported via three-component alkylation of N-heterocycle (purine nucleobase) with acetal (cyclic or acyclic, variously branched) and anhydride ...
Jan Frydrych, Lenka Poštová Slavětínská, Martin Dračínský, Zlatko Janeba   +3 more
doaj   +1 more source

Adjusting Cell‐Surface Interactions Through a Covalent Immobilization of Biomolecules

Advanced Materials Interfaces, EarlyView.
This review presents an overview of current and emerging immobilization techniques coupled with an in‐depth investigation of the underlying mechanisms governing the activity and stability of covalently immobilized biomolecules. The aim of this study is to serve as a guide for the development of long‐lasting biomedical coatings with versatile biological
Sara Shakibania, Manus J. P. Biggs, Katarzyna Krukiewicz   +2 more
wiley   +1 more source

Synthesis of purines and adenines containing the hexafluoroisopropyl group

Beilstein Journal of Organic Chemistry, 2020
Several new derivatives of adenine, purine, and theophylline containing the (CF3)2CH group connected to a nitrogen atom of the imidazole ring were prepared by the reaction of 2,2,4,4-tetrakis(trifluoromethyl)-1,3-dithietane (1) with the corresponding ...
Viacheslav Petrov, Rebecca J. Dooley, Alexander A. Marchione, Elizabeth L. Diaz, Brittany S. Clem, William Marshall   +5 more
doaj   +1 more source

Astrocytic and Oligodendrocytic P2X7 Receptors Determine Neuronal Functions in the CNS

Frontiers in Molecular Neuroscience, 2021
P2X7 receptors are members of the ATP-gated cationic channel family with a preferential localization at the microglial cells, the resident macrophages of the brain.
Ya-Fei Zhao, Yong Tang, Yong Tang, Peter Illes, Peter Illes, Peter Illes   +5 more
doaj   +1 more source

Recyclable All‐in‐One Organo‐Photo‐Auxiliaries Enabling (sp3)C−(sp3)C Coupling Reactions with Diverse Functionalities

Advanced Synthesis &Catalysis, Volume 367, Issue 5, March 4, 2025.
Abstract Photochemical C−C coupling reactions can be tailored to industrial chemical processes and preparations of pharmaceuticals. Recent approaches in this area are limited to using precious transition metal coordination complexes that facilitate light absorption and redox processes with benchtop chemicals. Herein, we propose a paradigm that involves
Samjhana Maharjan, Ravi Kishore Dakoju, Bella Albano, Pamela A. Ondiek, Joseph M. O'Shea, Angel G. Cosme‐Hernandez, Donald Wink, Barry C. Pemberton, Steven A. Lopez, A. Jean‐Luc Ayitou   +9 more
wiley   +1 more source