Results 51 to 60 of about 186,546 (339)

Purine-Metabolising Enzymes and Apoptosis in Cancer

Cancers, 2019
The enzymes of both de novo and salvage pathways for purine nucleotide synthesis are regulated to meet the demand of nucleic acid precursors during proliferation.
M. Camici, M. Garcia-Gil, R. Pesi, S. Allegrini, M. Tozzi   +4 more
semanticscholar   +1 more source

Genetic Engineering Methods in Primary T Cells

Advanced Therapeutics, EarlyView.
Primary T cells can be engineered to confer them with novel therapeutic functions, allowing them to treat a variety of conditions. Genetic engineering can be either stable or transient, aiming to either express or inhibit a target gene. This review discusses the various genetic engineering tools available as well as their characteristics and ...
Anthony Youssef, Hui‐Shan Li
wiley   +1 more source

PURIN-FREE DIETS. [PDF]

The Lancet, 1906
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Mackintosh, J. S., Jones, WatkinW
openaire   +6 more sources

Stress-induced inactivation of the Staphylococcus aureus purine biosynthesis repressor leads to hypervirulence

Nature Communications, 2019
Staphylococcus aureus is a significant cause of human infection. Here, we demonstrate that mutations in the transcriptional repressor of purine biosynthesis, purR, enhance the pathogenic potential of S. aureus.
Mariya I. Goncheva, Ronald S. Flannagan, Brigid E. Sterling, Holly A. Laakso, N. Friedrich, Julienne C. Kaiser, David W. Watson, C. Wilson, J. Sheldon, M. McGavin, P. Kiser, D. Heinrichs   +11 more
semanticscholar   +1 more source

Tailoring a Functional Synthetic Microbial Community Alleviates Fusobacterium nucleatum‐infected Colorectal Cancer via Ecological Control

Advanced Science, EarlyView.
The bottom‐up strategy based on multiomics data is used for the SynCom design, and it successfully inhibited F. nucleatum growth and achieved stable colonization in vivo. In addition, it promoted tryptophan metabolism and secondary bile acid conversion, reduced lipid accumulation, relieved microbiome disorder, decreased inflammatory reaction, and ...
Zhongkun Zhou, Mengyue Yang, Hong Fang, Baizhuo Zhang, Yunhao Ma, Yongyuan Li, Yingjie Liu, Zeying Cheng, Yuanchun Zhao, Zhenzhen Si, Hongmei Zhu, Peng Chen   +11 more
wiley   +1 more source

5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5'-Monophosphate (AICAR), a Highly Conserved Purine Intermediate with Multiple Effects

Metabolites, 2012
AICAR (5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5'-monophosphate) is a natural metabolic intermediate of purine biosynthesis that is present in all organisms.
Bertrand Daignan-Fornier, Benoît Pinson
doaj   +1 more source

Hypoglycemia Induces Diabetic Macrovascular Endothelial Dysfunction via Endothelial Cell PANoptosis, Macrophage Polarization, and VSMC Fibrosis

Advanced Science, EarlyView.
This study investigates hypoglycemia‐induced diabetic macrovascular endothelial dysfunction. It reveals that hypoglycemia triggers ZBP1‐dependent PANoptosis of endothelial cells, proinflammatory polarization of macrophages, and fibrosis of vascular smooth muscle cells (VSMCs) in diabetic mice.
Deyu Zuo, Yuce Peng, Guozhi Zhao, Zhesheng Cheng, Minghao Luo, Dingyi Lv, Shuting Chang, Na Li, Yanyao Huang, Xunjia Li, An He   +10 more
wiley   +1 more source

Host-derived Lactobacillus plantarum alleviates hyperuricemia by improving gut microbial community and hydrolase-mediated degradation of purine nucleosides

eLife
The gut microbiota is implicated in the pathogenesis of hyperuricemia (HUA) and gout. However, it remains unclear whether probiotics residing in the host gut, such as Lactobacillus, can prevent HUA development. Herein, we isolated Lactobacillus plantarum
Yang Fu, Xiao-Dan Luo, Jin-Ze Li, Qian-Yuan Mo, Xue Wang, Yue Zhao, You-Ming Zhang, Hao-Tong Luo, Dai-Yang Xia, Wei-Qing Ma, Jian-Ying Chen, Li-Hau Wang, Qiu-Yi Deng, Lukuyu Ben, Muhammad Kashif Saleemi, Xian-Zhi Jiang, Juan Chen, Kai Miao, Zhen-Ping Lin, Peng Zhang, Hui Ye, Qing-Yun Cao, Yong-Wen Zhu, Lin Yang, Qiang Tu, Wence Wang   +25 more
doaj   +1 more source

THE PURINES OF MUSCLE [PDF]

Journal of Biological Chemistry, 1912
"Reprinted from the Journal of biological chemistry, vol. XI, no. 3, 1912." ; "From the Rudolph Spreckels physiological laboratory of the University of California." ; Cover-title. ; Mode of access: Internet.
openaire   +1 more source

De novo synthesis of serine and glycine fuels purine nucleotide biosynthesis in human lung cancer tissues

Journal of Biological Chemistry, 2019
Nucleotide synthesis is essential to proliferating cells, but the preferred precursors for de novo biosynthesis are not defined in human cancer tissues.
T. Fan, Ronald C. Bruntz, Ye Yang, Huan Song, Yelena Chernyavskaya, Pan Deng, Yan Zhang, P. Shah, L. Beverly, Zhen Qi, A. Mahan, R. Higashi, C. Dang, A. Lane   +13 more
semanticscholar   +1 more source