Results 61 to 70 of about 148,463 (294)
Migrasomes in Ischemic Stroke: Molecular Landscape and Pathophysiological Impact
Advanced Science, EarlyView.Multi‐omics profiling of stroke patients exposes systemic molecular fingerprints of immune activation, oxidative stress and metabolic collapse. Complement and coagulation cascade, and cholesterol metabolism emerge as shared functional hallmarks of plasma migrasomes in stroke patients and migrasomes isolated from experimental stroke mice.
Huifen Zhou +16 more
wiley +1 more source
CAQ Corner: Basic concepts of transplant immunology
, 2022 Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley +1 more source
AGING MEDICINE, EarlyView.In the elderly, SUA and UCR are related to sarcopenia, but there are certain gender differences. ABSTRACT Objectives Sarcopenia is a progressive and systemic skeletal muscle disease. Uric acid is a powerful endogenous antioxidant and an indicator reflecting the nutritional status in the human body.
Yi‐Yang Liu +10 more
wiley +1 more source
Back Again to the Future: A New Era for Cerebroprotection
Annals of Neurology, EarlyView.Cerebroprotection is a fresh framework for designing neurological therapy that targets glia and vascular cells, in addition to neurons. In the future, successful cerebroprotection will involve targeting all elements of the neurovascular unit. Preclinical trials must include functional outcomes, as well as lesion morphometry.
Patrick Lyden
wiley +1 more source
Probiotics in Alleviating Hyperuricemia: Research Status, Mechanism of Action and Challenges
Shipin gongye ke-jiHyperuricemia (HUA) is a chronic metabolic disease, characterized by excessive uric acid in the blood, caused by purine metabolism disorders. Studies show that conventional clinical treatment methods have certain limitations, while probiotics have the ...
Xinru YANG +5 more
doaj +1 more source
Purine Phosphoribosyltransferases [PDF]
Journal of Biological Chemistry, 2000 S P, Craig, A E, Eakin
openaire +2 more sources
Untersuchungen zum Ursprung der Substratspezifität von Enzymen der Amidohydrolase‐Superfamilie
Angewandte Chemie, EarlyView.Umfassende Analysen zweier Enzymklassen aus der Amidohydrolase‐Superfamilie (AHS) ergaben, dass die Katalyse über eine 1,4‐ bzw. 1,6‐nukleophile konjugierte Addition abläuft und diese Eigenschaft die Substratspezifität bestimmt. Obwohl alle Substrate und Produkte vollständig achiral sind, führt dieser mechanistische Unterschied zu einer invertierten ...
Lukas Drexler +3 more
wiley +1 more source
MoleculesChagas disease and leishmaniasis are two neglected tropical diseases that affect millions of people in low- and middle-income tropical countries. These diseases caused by protozoan parasites pose significant global health challenges, which have been ...
Emmanuel Awucha Nwoke +4 more
doaj +1 more source
On the Origin of Substrate Specificity of Enzymes from the Amidohydrolase Superfamily
Angewandte Chemie International Edition, EarlyView.Comprehensive analyses of two enzyme classes from the amidohydrolase superfamily (AHS) revealed that catalysis proceeds either via 1,4 or 1,6 nucleophilic conjugate addition and that this property defines substrate specificity. Moreover, although all substrates and products are entirely achiral, this mechanistic difference results in an inverted ...
Lukas Drexler +3 more
wiley +1 more source
Food Science and Human WellnessGut microbiome is indispensable for maintaining normal brain function. Specifically, gut microbiota plays a causal role in sleep deprivation (SD)-induced cognitive impairment.
Peijun Tian +8 more
doaj +1 more source