Results 61 to 70 of about 124,162 (316)
Regulation of Microglial Functions by Purinergic Mechanisms in the Healthy and Diseased CNS
Cells, 2020 Microglial cells, the resident macrophages of the central nervous system (CNS), exist in a process-bearing, ramified/surveying phenotype under resting conditions.
Peter Illes +4 more
doaj +1 more source
Intestinal Inflammation as a Dysbiosis of Energy Procurement: New Insights into an Old Topic
Gut Microbes, 2021 Inflammatory bowel disease (IBD) coincides with profound shifts in microbiota and host metabolic energy supply and demand. The gastrointestinal epithelium is anatomically positioned to provide a selective barrier between the anaerobic luminal microbiota ...
J. Scott Lee +3 more
doaj +1 more source
The vanishing of self-extensions over n-symmetric algebras of quasitilted type [PDF]
arXiv, 2014 A ring R satisfies the Generalized Auslander-Reiten Condition if any R-module M with no self-extensions in degrees higher than m must have projective dimension at most m. We prove that this condition is satisfied by all n-symmetric algebras of quasitilted type- a broad class of self-injective algebras where every module is periodic under the Nakayama ...
arxiv
Targeting miRNA‐1a and miRNA‐15b: A Novel Combinatorial Strategy to Drive Adult Cardiac Regeneration
Advanced Science, EarlyView.The article explores a novel therapeutic strategy for cardiac regeneration by targeting miRNA‐1a and miRNA‐15b. Combinatorial inhibition of miR‐1a and miR‐15b enhances cardiomyocyte proliferation, improves heart function, and reduces fibrosis in myocardial infarction models.
Ting Yuan +16 more
wiley +1 more source
Solution of the Crow-Kimura and Eigen models for alphabets of arbitrary size by Schwinger spin coherent states [PDF]
, 2009 To represent the evolution of nucleic acid and protein sequence, we express the parallel and Eigen models for molecular evolution in terms of a functional integral representation with an $h$-letter alphabet, lifting the two-state, purine/pyrimidine assumption often made in quasi-species theory. For arbitrary $h$ and a general mutation scheme, we obtain
arxiv +1 more source
Advanced Science, EarlyView.The research findings indicate that dimethyl itaconate (DI) alleviates Escherichia coli (E. coli) induced endometritis by modulating the gut microbiota and enriching the abundance of norank_f_Muribaculaceae, thereby increasing the production of guanosine.
Yuhang He +6 more
wiley +1 more source
Lie Markov models with purine/pyrimidine symmetry [PDF]
arXiv, 2012 Continuous-time Markov chains are a standard tool in phylogenetic inference. If homogeneity is assumed, the chain is formulated by specifying time-independent rates of substitutions between states in the chain. In applications, there are usually extra constraints on the rates, depending on the situation.
arxiv
DISORDERS OF PURIN METABOLISM [PDF]
Journal of the American Medical Association, 1912 The old time term "uric acid diathesis" was an elastic expression, embracing such different conditions as gout, chronic rheumatism, uratic calculus, obesity and certain nephritides. In the light of more recent knowledge, the meaning of the term has been gradually narrowed until at the present time it includes only those diseases or clinical syndromes ...
Alfred C. Reed, George B. Wallace
openaire +3 more sources
Advanced Science, EarlyView.Drug‐induced renal damage impairs uric acid excretion, causing its accumulation in the serum, which subsequently infiltrates the cochlea. Xanthine oxidase and the ABCG2 transporter, critical in uric acid metabolism and excretion, undergo pathological changes in renal tubular and cochlear stria vascularis cells.
Suhan Guo +11 more
wiley +1 more source