Results 71 to 80 of about 285,864 (400)
Nature Communications, 2019 Staphylococcus aureus is a significant cause of human infection. Here, we demonstrate that mutations in the transcriptional repressor of purine biosynthesis, purR, enhance the pathogenic potential of S. aureus.
Mariya I. Goncheva +11 more
semanticscholar +1 more source
Electron transfer driven decomposition of adenine and selected analogs as probed by experimental and theoretical methods [PDF]
, 2018 We report on a combined experimental and theoretical study of electron transfer induced decomposition of adenine and a selection of analogue molecules in collisions with potassium atoms (K).
Bacchus-Montabonel, M.-C. +6 more
core +3 more sources
Molecular Oncology, EarlyView.Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim +8 more
wiley +1 more source
Vanishing of self-extensions over symmetric algebras [PDF]
, 2013 We study self-extensions of modules over symmetric artin algebras. We show that non-projective modules with eventually vanishing self-extensions must lie in AR components of stable type $\mathbb{Z}A_{\infty}$. Moreover, the degree of the highest non-vanishing self-extension of these modules is determined by their quasilength.
arxiv +1 more source
Serine, but not glycine, supports one-carbon metabolism and proliferation of cancer cells [PDF]
, 2014 Previous work has shown that some cancer cells are highly dependent on serine/glycine uptake for proliferation. Although serine and glycine can be interconverted and either might be used for nucleotide synthesis and one-carbon metabolism, we show that ...
Labuschagne, Christiaan F. +4 more
core +2 more sources
FEBS Open Bio, EarlyView.We obtained potential bacterial laccase‐like multicopper oxidase (LMCO) sequences through metagenomic sequencing. All sequences exhibited significant differences from known LMCOs in databases. To select the most promising candidates, we performed structure prediction and molecular docking using alphafold2, metal3d and rosetta.
Ting Cui +5 more
wiley +1 more source
Gene Algebra from a Genetic Code Algebraic Structure [PDF]
Journal of Mathematical Biology. 2005 Oct;51(4):431-57., 2004 The biological distinction between the base positions in the codon, the chemical types of bases (purine and pyrimidine) and their hydrogen bond number have been the most relevant codon properties used in the genetic code analysis. Now, these properties have allowed us to build a Genetic Code ring isomorphic to the ring (Z64, +,*) of the integer module ...
arxiv +1 more source
Metabolites, 2012 AICAR (5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5'-monophosphate) is a natural metabolic intermediate of purine biosynthesis that is present in all organisms.
Bertrand Daignan-Fornier, Benoît Pinson
doaj +1 more source
A study of the effects of exercise on the urinary metabolome using normalisation to individual metabolic output [PDF]
, 2015 Aerobic exercise, in spite of its multi-organ benefit and potent effect on the metabolome, has yet to be investigated comprehensively via an untargeted metabolomics technology.
Anthony, Nahoum +5 more
core +2 more sources
Journal of Biological Chemistry, 2019 Nucleotide synthesis is essential to proliferating cells, but the preferred precursors for de novo biosynthesis are not defined in human cancer tissues.
T. Fan +13 more
semanticscholar +1 more source