Results 71 to 80 of about 209,598 (340)

Hybrid Molecules with Purine and Pyrimidine Derivatives for Antitumor Therapy: News, Perspectives, and Future Directions

Molecules
Cancer is a leading cause of death globally, claiming millions of lives each year. Despite the availability of numerous anticancer drugs, the need for new treatment options remains essential. Many current therapies come with significant toxicity, lead to
Simona Iacob (Ciobotaru), Claudia-Simona Stefan, Aurel Nechita, Madalina-Nicoleta Matei, Elena-Lacramioara Lisa, Dana Tutunaru, Iuliu Fulga, Ana Fulga, Alina-Georgiana Cristea (Hohota), Oana-Maria Dragostin   +9 more
doaj   +1 more source

Synthesis a Number of Triazene Compounds Derived From Purine and Studying their Biological Activity on Pathogenic Bacteria [PDF]

مجلة جامعة الانبار للعلوم الصرفة, 2012
In this research a number of compounds were prepared by coupling dizonium salts with purine bases. The structures of the prepared compounds were identified by ultra violet ,infra red spectra and Elemental (C.H.N) analysis .The biological activity of ...
Ahmed .M. Mohamed, Hameed H.Ali, Yousif. H. Khalaf   +2 more
doaj   +1 more source

Enhanced acetic acid stress tolerance and ethanol production in Saccharomyces cerevisiae by modulating expression of the de novo purine biosynthesis genes

Biotechnology for Biofuels, 2019
BackgroundYeast strains that are tolerant to multiple environmental stresses are highly desired for various industrial applications. Despite great efforts in identifying key genes involved in stress tolerance of budding yeast Saccharomyces cerevisiae ...
Mingming Zhang, Liang Xiong, Ya-Jie Tang, Muhammad Aamer Mehmood, Z. Zhao, F. Bai, Xinqing Zhao   +6 more
semanticscholar   +1 more source

Microneedle‐Based Biofertilizer Delivery Improves Plant Growth Through Microbiome Engineering

Advanced Functional Materials, EarlyView.
This figure shows how microneedles are used to deliver biofertilizers to enhance plant growth through microbial migration, metabolic reprogramming, and changes in plant endogenous microbiome. Abstract This study presents a microneedle‐based system for the delivery of rhizospheric biofertilizers into plant tissues to enhance growth.
Zhicheng Le, Sevugan Mayalagu, Cheng‐Yen Chen, Raktim Bhattacharya, Abhishek Gupta, Jingyuan Li, Zhi Wei Norman Teo, Yufeng Shou, Arya Gopinath MP, Danni Zhong, Tedrick Thomas Salim Lew, Hao Yu, Naweed I. Naqvi, Sanjay Swarup, Andy Tay   +14 more
wiley   +1 more source

Stress-induced inactivation of the Staphylococcus aureus purine biosynthesis repressor leads to hypervirulence

Nature Communications, 2019
Staphylococcus aureus is a significant cause of human infection. Here, we demonstrate that mutations in the transcriptional repressor of purine biosynthesis, purR, enhance the pathogenic potential of S. aureus.
Mariya I. Goncheva, Ronald S. Flannagan, Brigid E. Sterling, Holly A. Laakso, N. Friedrich, Julienne C. Kaiser, David W. Watson, C. Wilson, J. Sheldon, M. McGavin, P. Kiser, D. Heinrichs   +11 more
semanticscholar   +1 more source

Targeting Post‐Irradiation Thyroid Dysfunction: Electrospun Scaffolds As A Dual‐Action Approach for Antioxidant and Immune Modulation

Advanced Healthcare Materials, EarlyView.
Radiation‐induced hypothyroidism follows head and neck radiotherapy due to oxidative stress and inflammation. Electrospun polycaprolactone scaffolds containing adenosine have potential to modulate thyroid repair. Scaffolds enhance thyrocyte proliferation, antioxidant enzymes glutathione peroxidase and catalase, reduce senescence and apoptosis markers ...
Maria Heim, Ella‐Louise Handley, Daniel Grant, Lizi M. Hegarty, Elaine Emmerson, Anthony Callanan   +5 more
wiley   +1 more source

Metabolome and Transcriptome Association Analysis Reveals Dynamic Regulation of Purine Metabolism and Flavonoid Synthesis in Transdifferentiation during Somatic Embryogenesis in Cotton

International Journal of Molecular Sciences, 2019
Plant regeneration via somatic embryogenesis (SE) is a key step during genetic engineering. In the current study, integrated widely targeted metabolomics and RNA sequencing were performed to investigate the dynamic metabolic and transcriptional profiling
Huihui Guo, Haixia Guo, Li Zhang, Zhengmin Tang, Xiaoman Yu, Jianfei Wu, Fanchang Zeng   +6 more
semanticscholar   +1 more source

Vm–MSI: a Vancomycin–Antimicrobial Peptide Conjugate Combating Resistant Bacteria and Broadening the Antimicrobial Spectrum

Advanced Science, EarlyView.
A series of vancomycin‐antimicrobial peptide conjugates is synthesized and evaluated to identify the optimal combination. Vm‐MSI, selected from multiple candidates, exhibited potent activity against vancomycin‐resistant and Gram‐negative bacteria by disrupting membranes and inducing oxidative stress, thereby expanding vancomycin's antibacterial ...
Shuangyu Li, Kang Wang, Wenzhuang Shi, Xu Wang, Duxin Li, Yanli Liu, Peng Zhang, Yipeng Wang   +7 more
wiley   +1 more source

Possible Therapeutic Strategy Involving the Purine Synthesis Pathway Regulated by ITK in Tongue Squamous Cell Carcinoma [PDF]

, 2021
Kaoru Onidani, Nami Miura, Yuki Sugiura, Yuichi Abe, Yukio Watabe, Takanori Kakuya, Taisuke Mori, Seiichi Yoshimoto, Jun Adachi, Takao Kiyoi, Yasuaki Kabe, Makoto Suematsu, Takeshi Tomonaga, Takahiko Shibahara, Kazufumi Honda   +14 more
openalex   +1 more source

De novo synthesis of serine and glycine fuels purine nucleotide biosynthesis in human lung cancer tissues

Journal of Biological Chemistry, 2019
Nucleotide synthesis is essential to proliferating cells, but the preferred precursors for de novo biosynthesis are not defined in human cancer tissues.
T. Fan, Ronald C. Bruntz, Ye Yang, Huan Song, Yelena Chernyavskaya, Pan Deng, Yan Zhang, P. Shah, L. Beverly, Zhen Qi, A. Mahan, R. Higashi, C. Dang, A. Lane   +13 more
semanticscholar   +1 more source