Results 81 to 90 of about 187,335 (337)

Single‐Cell RNA Sequencing Delineates Renal Anti‐Fibrotic Mechanisms Mediated by TRPC6 Inhibition

Advanced Science, EarlyView.
Single‐cell transcriptomics reveals how TRPC6 inhibition alters renal cell composition and gene expression in CKD. The study uncovers a novel endothelial subpopulation (ECRIN), highlights key inflammatory and fibrotic pathways, and identifies a Prnp‐driven network linked to fibrosis resolution, offering mechanistic insight into TRPC6 as a potential ...
Yao Xu, Zhihuang Zheng, Marleen Silke Oswald, Guozhe Cheng, Jun Liu, Qidi Zhai, Ute Kruegel, Michael Schaefer, Holger Gerhardt, Nicole Endlich, Maik Gollasch, Stefan Simm, Dmitry Tsvetkov   +12 more
wiley   +1 more source

Yeast to Study Human Purine Metabolism Diseases

Cells, 2019
Purine nucleotides are involved in a multitude of cellular processes, and the dysfunction of purine metabolism has drastic physiological and pathological consequences.
B. Daignan-Fornier, B. Pinson
semanticscholar   +1 more source

STAT6 Activation Exacerbates Ferroptosis in Airway Epithelium by Inhibiting PRKN‐Mediated Mitophagy in Pulmonary Fibrosis

Advanced Science, EarlyView.
This study uncovers STAT6‐driven pulmonary fibrosis (PF) via suppression of PRKN‐mediated airway epithelial mitophagy, triggering mitochondrial dysfunction and ferroptosis. Rifabutin is identified as a potent STAT6 inhibitor that effectively reverses fibrotic progression. These findings reveal the STAT6‐PRKN axis as a pathogenic regulator and provide a
Youjing Yang, Guangbin Huang, Tao Zhang, Yi Ling, Junyu Jiang, Dingyuan Du, Yu Ma, Shasha Tao   +7 more
wiley   +1 more source

Microtubule-directed transport of purine metabolons drives their cytosolic transit to mitochondria

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance This study draws on the power of superresolution microscopy to investigate how metabolons behave near different subcellular components. We revealed an interdependent relationship among purinosomes, mitochondria, and microtubules.
C. Chan, Anthony M. Pedley, Doory Kim, C. Xia, X. Zhuang, S. Benkovic   +5 more
semanticscholar   +1 more source

FLASH Irradiation Modulates Immune Responses and Accelerates Lung Recovery: A Single‐Cell Perspective

Advanced Science, EarlyView.
Single‐cell RNA sequencing reveals distinct immune responses to FLASH versus conventional dose rate irradiation in early radiation‐induced lung injury. FLASH irradiation reduces Ccrl2⁺ neutrophil infiltration, activates CD4⁺ CD40L⁺ Th cells, restrains pro‐inflammatory Mefv⁺ monocytes, and enhances epithelial repair via TGF‐β signaling, underscoring its
Hao Lu, Menghua Li, Cheng Quan, Caihui Li, Dawei Li, Zhihui Li, Jing Xu, Lihui Zhang, Qixiang Liu, Guofu Dong, Changzhen Wang   +10 more
wiley   +1 more source

Proteogenomic characterization of cholangiocarcinoma

Hepatology, EarlyView., 2022
Proteogenomic characterization of cholangiocarcinoma with therapeutic strategies Abstract Background and Aims Cholangiocarcinoma (CCA) is a highly heterogeneous cancer with limited understanding and few effective therapeutic approaches. We aimed at providing a proteogenomic CCA characterization to inform biological processes and treatment ...
Mengjie Deng, Peng Ran, Lingli Chen, Yunzhi Wang, Zixiang Yu, Ke Cai, Jinwen Feng, Zhaoyu Qin, Yanan Yin, Subei Tan, Yang Liu, Chen Xu, Guoming Shi, Yuan Ji, Jian‐Yuan Zhao, Jian Zhou, Jia Fan, Yingyong Hou, Chen Ding   +18 more
wiley   +1 more source

Regulation of Microglial Functions by Purinergic Mechanisms in the Healthy and Diseased CNS

Cells, 2020
Microglial cells, the resident macrophages of the central nervous system (CNS), exist in a process-bearing, ramified/surveying phenotype under resting conditions.
Peter Illes, Patrizia Rubini, Henning Ulrich, Yafei Zhao, Yong Tang   +4 more
doaj   +1 more source

Intestinal Inflammation as a Dysbiosis of Energy Procurement: New Insights into an Old Topic

Gut Microbes, 2021
Inflammatory bowel disease (IBD) coincides with profound shifts in microbiota and host metabolic energy supply and demand. The gastrointestinal epithelium is anatomically positioned to provide a selective barrier between the anaerobic luminal microbiota ...
J. Scott Lee, Ruth X. Wang, Erica E. Alexeev, Sean P. Colgan   +3 more
doaj   +1 more source

DISORDERS OF PURIN METABOLISM [PDF]

Journal of the American Medical Association, 1912
The old time term "uric acid diathesis" was an elastic expression, embracing such different conditions as gout, chronic rheumatism, uratic calculus, obesity and certain nephritides. In the light of more recent knowledge, the meaning of the term has been gradually narrowed until at the present time it includes only those diseases or clinical syndromes ...
Alfred C. Reed, George B. Wallace
openaire   +3 more sources

Hypoxia modulates the purine salvage pathway and decreases red blood cell and supernatant levels of hypoxanthine during refrigerated storage

Haematologica, 2017
Hypoxanthine catabolism in vivo is potentially dangerous as it fuels production of urate and, most importantly, hydrogen peroxide. However, it is unclear whether accumulation of intracellular and supernatant hypoxanthine in stored red blood cell units is
T. Nemkov, K. Sun, J. Reisz, Anren Song, T. Yoshida, A. Dunham, M. Wither, R. Francis, R. Roach, Monika Dzieciatkowska, S. Rogers, A. Doctor, Anastasios G. Kriebardis, M. Antonelou, I. Papassideri, C. Young, Tiffany A. Thomas, K. Hansen, S. Spitalnik, Yang Xia, J. Zimring, E. Hod, A. D’Alessandro   +22 more
semanticscholar   +1 more source