Potential Mechanisms Connecting Purine Metabolism and Cancer Therapy
Frontiers in Immunology, 2018 Unrestricted cell proliferation is a hallmark of cancer. Purines are basic components of nucleotides in cell proliferation, thus impaired purine metabolism is associated with the progression of cancer.
Jie Yin +9 more
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USP5 regulates purine metabolism and represents a therapeutic target in esophageal cancer [PDF]
Cell Death and DiseaseUbiquitination is a critical regulator of cancer development, yet the role of deubiquitinases in purine metabolism remains largely unexplored. In this study, untargeted metabolomic analysis revealed a significant upregulation of purine metabolism in ...
Kexin Zhao +14 more
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Yeast to Study Human Purine Metabolism Diseases
Cells, 2019 Purine nucleotides are involved in a multitude of cellular processes, and the dysfunction of purine metabolism has drastic physiological and pathological consequences.
Bertrand Daignan-Fornier, Benoît Pinson
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The impact of bacterial purine metabolism on antibiotic efficacy [PDF]
npj Antimicrobials and ResistanceMetabolism plays a key role in the three antibiotic evasion strategies used by bacteria: tolerance, persistence and resistance. Modulation of purine metabolism is emerging as a common, and clinically relevant, contributor to tolerant and resistant ...
Claire E. Stevens +2 more
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Exploration of purine metabolism-related genes in the development of osteoporosis by integrated analyses and experiments [PDF]
European Journal of Medical ResearchObjective Metabolomics analyses suggest abnormal purine metabolism during the development of osteoporosis. This study aimed to investigate the role of purine metabolism-related genes in osteoporosis.
Yuqing Zeng +3 more
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In Vitro and In Vivo Evaluation of Pediococcus acidilactici Pedio6-1 for Purine Metabolism Modulation in Diet-Induced Obese Mice [PDF]
MicroorganismsGut lactic acid bacteria are emerging as potential targets for modulating host purine metabolism and alleviating hyperuricemia-related disorders. This study aimed to isolate purine-degrading lactic acid bacterial strains from porcine intestine and ...
Haohua Fu +8 more
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The Role of Purine Metabolism and Uric Acid in Postnatal Neurologic Development [PDF]
MoleculesThis review explores the essential roles of purine metabolism including the catabolic product, uric acid, in the development of dopaminergic neurons of the substantia nigra pars compacta. The high energy requirements of the substantia nigra pars compacta
Lauren N. Mileti, James D. Baleja
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Microcephaly-associated protein WDR62 supports purine metabolism by interacting with co-chaperone BAG2 [PDF]
The EMBO JournalInherited mutations in the spindle pole-associated scaffold protein WDR62 cause autosomal recessive primary microcephaly. Previous research has characterised the roles of WDR62 in the regulation of spindle dynamics, cell division, and brain development ...
Matthew J Morris +9 more
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Purine metabolism in plant pathogenic fungi
Frontiers in MicrobiologyIn eukaryotic cells, purine metabolism is the way to the production of deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) and plays key roles in various biological processes.
Manli Sun +3 more
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Disorder of purine metabolism in the etiopathogenesis of urate nephrolithiasis
Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2023 Urinary stone disease (USD) is a polyetiological urological disease caused by both exogenous and endogenous factors, including hereditary ones. It is characterized by the appearance of stones in the kidneys and urinary tract, and a tendency to relapse ...
S. I. Vorotyntsev +2 more
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