Results 1 to 10 of about 1,394,357 (370)
A Novel Purine and Uric Metabolism Signature Predicting the Prognosis of Hepatocellular Carcinoma [PDF]
Frontiers in Genetics, 2022 Background: Hepatocellular carcinoma (HCC) is regarded as one of the most common cancers in the world with a poor prognosis. Patients with HCC often have abnormal purine and uric acid metabolism, but their relationship with prognosis is unclear.Methods ...
Shengjie Yang +5 more
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The Role of Purine Metabolism and Uric Acid in Postnatal Neurologic Development [PDF]
MoleculesThis review explores the essential roles of purine metabolism including the catabolic product, uric acid, in the development of dopaminergic neurons of the substantia nigra pars compacta. The high energy requirements of the substantia nigra pars compacta
Lauren N. Mileti, James D. Baleja
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Germ-Free Conditions Modulate Host Purine Metabolism, Exacerbating Adenine-Induced Kidney Damage [PDF]
Toxins, 2020 Alterations in microbiota are known to affect kidney disease conditions. We have previously shown that germ-free conditions exacerbated adenine-induced kidney damage in mice; however, the mechanism by which this occurs has not been elucidated. To explore
Eikan Mishima +11 more
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Purine metabolism in plant pathogenic fungi [PDF]
Frontiers in MicrobiologyIn eukaryotic cells, purine metabolism is the way to the production of deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) and plays key roles in various biological processes.
Manli Sun +3 more
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HIF-1α-HPRT1 axis promotes tumorigenesis and gefitinib resistance by enhancing purine metabolism in EGFR-mutant lung adenocarcinoma [PDF]
Journal of Experimental & Clinical Cancer ResearchBackground The mutations of oncogenic epidermal growth factor receptor (EGFR) is an important cause of lung adenocarcinoma (LUAD) malignance. It has been knowm that metabolic reprogramming is an important hallmark of malignant tumors, and purine ...
Pengyu Geng +10 more
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Targeting purine metabolism in ovarian cancer
Journal of Ovarian Research, 2022 Purine, an abundant substrate in organisms, is a critical raw material for cell proliferation and an important factor for immune regulation. The purine de novo pathway and salvage pathway are tightly regulated by multiple enzymes, and dysfunction in ...
Jingchun Liu +7 more
doaj +2 more sources
Purine metabolism-related genes and immunization in thyroid eye disease were validated using bioinformatics and machine learning [PDF]
Scientific Reports, 2023 Thyroid eye disease (TED), an autoimmune inflammatory disorder affecting the orbit, exhibits a range of clinical manifestations. While the disease presentation can vary, cases that adhere to a prototypical pattern typically commence with mild symptoms ...
Zixuan Wu +4 more
semanticscholar +2 more sources
Antibiotic-induced gut microbiota dysbiosis has a functional impact on purine metabolism
BMC Microbiology, 2023 Background Dysbiosis of the gut microbiota is closely linked to hyperuricemia. However, the effect of the microbiome on uric acid (UA) metabolism remains unclear.
Xin Liu +6 more
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Frontiers in Oncology, 2021 BackgroundDeregulated purine metabolism is critical for fast-growing tumor cells by providing nucleotide building blocks and cofactors. Importantly, purine antimetabolites belong to the earliest developed anticancer drugs and are still prescribed in ...
Wen-Jing Su +7 more
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Theranostics, 2020 Background: Gut microbiota, which plays a crucial role in inflammatory bowel diseases (IBD), might have therapeutic benefits for ulcerative colitis or Crohn's disease. Targeting gut microbiota represents a new treatment strategy for IBD patients.
Jiawei Wu +9 more
semanticscholar +2 more sources