Results 1 to 10 of about 1,258,600 (365)

Targeting purine metabolism in ovarian cancer [PDF]

Journal of Ovarian Research, 2022
Purine, an abundant substrate in organisms, is a critical raw material for cell proliferation and an important factor for immune regulation. The purine de novo pathway and salvage pathway are tightly regulated by multiple enzymes, and dysfunction in ...
Jingchun Liu, Shasha Hong, Jiang Yang, Xiaoyi Zhang, Ying Wang, Haoyu Wang, Jiaxin Peng, Li Hong   +7 more
doaj   +3 more sources

Antibiotic-induced gut microbiota dysbiosis has a functional impact on purine metabolism [PDF]

BMC Microbiology, 2023
Background Dysbiosis of the gut microbiota is closely linked to hyperuricemia. However, the effect of the microbiome on uric acid (UA) metabolism remains unclear.
Xin Liu, Leyong Ke, Ke Lei, Qian Yu, Wenqing Zhang, Changgui Li, Zibin Tian   +6 more
doaj   +3 more sources

A circular network of purine metabolism as coregulators of dilated cardiomyopathy [PDF]

Journal of Translational Medicine, 2022
Background The crosstalk of purine biosynthesis and metabolism exists to balance the cell energy production, proliferation, survival and cytoplasmic environment stability, but disorganized mechanics of with respect to developing heart failure (HF) is ...
Ge Wang, Rongjun Zou, Libao Liu, Zongtao Wang, Zengxiao Zou, Songtao Tan, Wenliu Xu, Xiaoping Fan   +7 more
doaj   +3 more sources

Purine Metabolism Dysfunctions: Experimental Methods of Detection and Diagnostic Potential. [PDF]

Int J Mol Sci, 2023
Purines, such as adenine and guanine, perform several important functions in the cell. They are found in nucleic acids; are structural components of some coenzymes, including NADH and coenzyme A; and have a crucial role in the modulation of energy ...
Cicero AFG, Fogacci F, Di Micoli V, Angeloni C, Giovannini M, Borghi C.   +5 more
europepmc   +2 more sources

Identification of Key Genes in Purine Metabolism as Prognostic Biomarker for Hepatocellular Carcinoma

Frontiers in Oncology, 2021
BackgroundDeregulated purine metabolism is critical for fast-growing tumor cells by providing nucleotide building blocks and cofactors. Importantly, purine antimetabolites belong to the earliest developed anticancer drugs and are still prescribed in ...
Wen-Jing Su, Pei-Zhi Lu, Yong Wu, Kumari Kalpana, Cheng-Kun Yang, Guo-Dong Lu, Guo-Dong Lu, Guo-Dong Lu   +7 more
doaj   +2 more sources

Evolutionary impacts of purine metabolism genes on mammalian oxidative stress adaptation. [PDF]

Zool Res, 2022
Many mammals risk damage from oxidative stress stemming from frequent dives (i.e., cycles of ischemia/reperfusion and hypoxia/reoxygenation), high altitude and subterranean environments, or powered flight.
Tian R, Yang C, Chai SM, Guo H, Seim I, Yang G.   +5 more
europepmc   +2 more sources

Germ-Free Conditions Modulate Host Purine Metabolism, Exacerbating Adenine-Induced Kidney Damage

Toxins, 2020
Alterations in microbiota are known to affect kidney disease conditions. We have previously shown that germ-free conditions exacerbated adenine-induced kidney damage in mice; however, the mechanism by which this occurs has not been elucidated. To explore
Eikan Mishima, Mariko Ichijo, Takeshi Kawabe, Koichi Kikuchi, Yukako Akiyama, Takafumi Toyohara, Takehiro Suzuki, Chitose Suzuki, Atsuko Asao, Naoto Ishii, Shinji Fukuda, Takaaki Abe   +11 more
doaj   +2 more sources

Potential Mechanisms Connecting Purine Metabolism and Cancer Therapy

Frontiers in Immunology, 2018
Unrestricted cell proliferation is a hallmark of cancer. Purines are basic components of nucleotides in cell proliferation, thus impaired purine metabolism is associated with the progression of cancer.
Jie Yin, Jie Yin, Jie Yin, Wenkai Ren, Xingguo Huang, Xingguo Huang, Jinping Deng, Tiejun Li, Yulong Yin, Yulong Yin   +9 more
doaj   +2 more sources

Purine metabolism regulates DNA repair and therapy resistance in glioblastoma

Nature Communications, 2020
Targeting genotype-independent abnormalities may overcome therapy resistance in glioblastoma despite intratumoral genomic heterogeneity. Here, the authors show that glioblastoma radiation resistance is promoted by purine metabolism and can be overcome by
Weihua Zhou, Yangyang Yao, Andrew J. Scott, Kari Wilder-Romans, Joseph J. Dresser, Christian K. Werner, Hanshi Sun, Drew Pratt, Peter Sajjakulnukit, Shuang G. Zhao, Mary Davis, Barbara S. Nelson, Christopher J. Halbrook, Li Zhang, Francesco Gatto, Yoshie Umemura, Angela K. Walker, Maureen Kachman, Jann N. Sarkaria, Jianping Xiong, Meredith A. Morgan, Alnawaz Rehemtualla, Maria G. Castro, Pedro Lowenstein, Sriram Chandrasekaran, Theodore S. Lawrence, Costas A. Lyssiotis, Daniel R. Wahl   +27 more
doaj   +2 more sources

Purine metabolism in plant pathogenic fungi [PDF]

Frontiers in Microbiology
In eukaryotic cells, purine metabolism is the way to the production of deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) and plays key roles in various biological processes.
Manli Sun, Pengbo Dai, Zhiyan Cao, Jingao Dong   +3 more
doaj   +2 more sources