Results 1 to 10 of about 80,904 (162)
Targeting purine metabolism in ovarian cancer
Journal of Ovarian Research, 2022 Purine, an abundant substrate in organisms, is a critical raw material for cell proliferation and an important factor for immune regulation. The purine de novo pathway and salvage pathway are tightly regulated by multiple enzymes, and dysfunction in ...
Jingchun Liu +7 more
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Frontiers in Bioscience-Landmark, 2023 Background: Metabolic reprogramming provides a new perspective for understanding cancer. The targeting of dysregulated metabolic pathways may help to reprogram the immune status of the tumor microenvironment (TME), thereby increasing the effectiveness of
Hui Liu +4 more
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Рациональная фармакотерапия в кардиологии, 2016 Aim. To study purine metabolism and lipid peroxidation in patients with acute myocardial infarction with ST segment elevation (STEMI) in dependence on severity of acute heart failure (AHF). To evaluate effects of thrombolytic therapy on purine metabolism
E. V. Horolets +3 more
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Potential Mechanisms Connecting Purine Metabolism and Cancer Therapy
Frontiers in Immunology, 2018 Unrestricted cell proliferation is a hallmark of cancer. Purines are basic components of nucleotides in cell proliferation, thus impaired purine metabolism is associated with the progression of cancer.
Jie Yin +9 more
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Antibiotic-induced gut microbiota dysbiosis has a functional impact on purine metabolism
BMC Microbiology, 2023 Background Dysbiosis of the gut microbiota is closely linked to hyperuricemia. However, the effect of the microbiome on uric acid (UA) metabolism remains unclear.
Xin Liu +6 more
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The need for purine examination on fisherman
Jurnal Teknologi Laboratorium, 2021 The need for purine check on Fisherman is important because when the fisherman excess consuming highly purine contained in the food in a long rime periode will cause purine metabolism disorder and can lead to purine deposition in joint tissue and ...
Ketrina Konoralma +5 more
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Germ-Free Conditions Modulate Host Purine Metabolism, Exacerbating Adenine-Induced Kidney Damage
Toxins, 2020 Alterations in microbiota are known to affect kidney disease conditions. We have previously shown that germ-free conditions exacerbated adenine-induced kidney damage in mice; however, the mechanism by which this occurs has not been elucidated. To explore
Eikan Mishima +11 more
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Metabolism drives macrophage heterogeneity in the tumor microenvironment
Cell Reports, 2022 Summary: Tumor-associated macrophages (TAMs) are a major cellular component in the tumor microenvironment (TME). However, the relationship between the phenotype and metabolic pattern of TAMs remains poorly understood.
Shasha Li +15 more
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Purine and pyrimidine metabolism [PDF]
Proceedings of the Nutrition Society, 1982 The pathways of purine biosynthesis and degradation have been elucidated during the last 30 years; the regulation of the mechanisms involved is not yet fully understood, particularly with respect to quantitative aspects. Research into inborn errors of purine metabolism has provided valuable insights into purine synthesis and salvage pathways. Nutrition
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Frontiers in Oncology, 2021 BackgroundDeregulated purine metabolism is critical for fast-growing tumor cells by providing nucleotide building blocks and cofactors. Importantly, purine antimetabolites belong to the earliest developed anticancer drugs and are still prescribed in ...
Wen-Jing Su +7 more
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