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The impact of bacterial purine metabolism on antibiotic efficacy [PDF]
npj Antimicrobials and ResistanceMetabolism plays a key role in the three antibiotic evasion strategies used by bacteria: tolerance, persistence and resistance. Modulation of purine metabolism is emerging as a common, and clinically relevant, contributor to tolerant and resistant ...
Claire E. Stevens +2 more
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The Role of Purine Metabolism and Uric Acid in Postnatal Neurologic Development [PDF]
MoleculesThis review explores the essential roles of purine metabolism including the catabolic product, uric acid, in the development of dopaminergic neurons of the substantia nigra pars compacta. The high energy requirements of the substantia nigra pars compacta
Lauren N. Mileti, James D. Baleja
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Potential Mechanisms Connecting Purine Metabolism and Cancer Therapy
Frontiers in Immunology, 2018 Unrestricted cell proliferation is a hallmark of cancer. Purines are basic components of nucleotides in cell proliferation, thus impaired purine metabolism is associated with the progression of cancer.
Jie Yin, Wenkai Ren, Xingguo Huang
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Ecotoxicology and Environmental Safety, 2023 Cadmium (Cd) exposure has been associated with the development of enterohepatic circulation disorders and hyperuricemia, but the possible contribution of chronic low-dose Cd exposure to disease progression is still need to be explored.
Maichao Li, Xinde Li, Meng Xiu
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Yeast to Study Human Purine Metabolism Diseases
Cells, 2019 Purine nucleotides are involved in a multitude of cellular processes, and the dysfunction of purine metabolism has drastic physiological and pathological consequences.
Bertrand Daignan-Fornier +2 more
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Purine metabolism in plant pathogenic fungi [PDF]
Frontiers in MicrobiologyIn eukaryotic cells, purine metabolism is the way to the production of deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) and plays key roles in various biological processes.
Manli Sun +3 more
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Targeting purine metabolism in ovarian cancer
Journal of Ovarian Research, 2022 Purine, an abundant substrate in organisms, is a critical raw material for cell proliferation and an important factor for immune regulation. The purine de novo pathway and salvage pathway are tightly regulated by multiple enzymes, and dysfunction in ...
Jingchun Liu +7 more
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Antibiotic-induced gut microbiota dysbiosis has a functional impact on purine metabolism
BMC Microbiology, 2023 Background Dysbiosis of the gut microbiota is closely linked to hyperuricemia. However, the effect of the microbiome on uric acid (UA) metabolism remains unclear.
Xin Liu +6 more
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Purine Metabolism Dysfunctions: Experimental Methods of Detection and Diagnostic Potential
International Journal of Molecular Sciences, 2023 Purines, such as adenine and guanine, perform several important functions in the cell. They are found in nucleic acids; are structural components of some coenzymes, including NADH and coenzyme A; and have a crucial role in the modulation of energy ...
Arrigo F G Cicero +2 more
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International Journal of Molecular Sciences, 2023 This present study was conducted to provide evidence and an explanation for the apoptosis that occurs in the marine rotifer Brachionus plicatilis when facing 2,2′,4,4′-tetrabromodiphenyl ether (BDE-47) stress.
Sai Cao, You Wang
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