Exploration of purine metabolism-related genes in the development of osteoporosis by integrated analyses and experiments [PDF]
European Journal of Medical ResearchObjective Metabolomics analyses suggest abnormal purine metabolism during the development of osteoporosis. This study aimed to investigate the role of purine metabolism-related genes in osteoporosis.
Yuqing Zeng +3 more
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The impact of bacterial purine metabolism on antibiotic efficacy [PDF]
npj Antimicrobials and ResistanceMetabolism plays a key role in the three antibiotic evasion strategies used by bacteria: tolerance, persistence and resistance. Modulation of purine metabolism is emerging as a common, and clinically relevant, contributor to tolerant and resistant ...
Claire E. Stevens +2 more
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The Role of Purine Metabolism and Uric Acid in Postnatal Neurologic Development [PDF]
MoleculesThis review explores the essential roles of purine metabolism including the catabolic product, uric acid, in the development of dopaminergic neurons of the substantia nigra pars compacta. The high energy requirements of the substantia nigra pars compacta
Lauren N. Mileti, James D. Baleja
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Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis [PDF]
Molecular OncologyColorectal cancer (CRC) is widely recognized for its high prevalence and significant mortality rates, and purine metabolism has been serving as a potential therapeutic target.
Sungyeon Kim +8 more
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Purine metabolism in plant pathogenic fungi [PDF]
Frontiers in MicrobiologyIn eukaryotic cells, purine metabolism is the way to the production of deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) and plays key roles in various biological processes.
Manli Sun +3 more
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Resensitizing β‐Lactams by Reprogramming Purine Metabolism in Small Colony Variant for Osteomyelitis Treatment [PDF]
Advanced ScienceSmall colony variant (SCV) is strongly linked to antibiotic resistance and the persistence of osteomyelitis. However, the intrinsic phenotypic instability of SCV has hindered a thorough investigation of its pathogenic mechanisms.
Tingwang Shi +11 more
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Disorder of purine metabolism in the etiopathogenesis of urate nephrolithiasis
Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2023 Urinary stone disease (USD) is a polyetiological urological disease caused by both exogenous and endogenous factors, including hereditary ones. It is characterized by the appearance of stones in the kidneys and urinary tract, and a tendency to relapse ...
S. I. Vorotyntsev +2 more
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A Novel Purine and Uric Metabolism Signature Predicting the Prognosis of Hepatocellular Carcinoma
Frontiers in Genetics, 2022 Background: Hepatocellular carcinoma (HCC) is regarded as one of the most common cancers in the world with a poor prognosis. Patients with HCC often have abnormal purine and uric acid metabolism, but their relationship with prognosis is unclear.Methods ...
Shengjie Yang +5 more
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Purine signaling pathway dysfunction in autism spectrum disorders: Evidence from multiple omics data
Frontiers in Molecular Neuroscience, 2023 IntroductionPrevious studies have suggested that the dysregulation of purine metabolism may be associated with autism spectrum disorder (ASD). Here, we adopted metabolomics and transcriptomics to verify and explore the underlying molecular mechanism of ...
Si Dai +5 more
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Targeting purine metabolism in ovarian cancer
Journal of Ovarian Research, 2022 Purine, an abundant substrate in organisms, is a critical raw material for cell proliferation and an important factor for immune regulation. The purine de novo pathway and salvage pathway are tightly regulated by multiple enzymes, and dysfunction in ...
Jingchun Liu +7 more
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