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The Role of Purine Metabolism and Uric Acid in Postnatal Neurologic Development [PDF]

open access: yesMolecules
This review explores the essential roles of purine metabolism including the catabolic product, uric acid, in the development of dopaminergic neurons of the substantia nigra pars compacta. The high energy requirements of the substantia nigra pars compacta
Lauren N. Mileti, James D. Baleja
doaj   +2 more sources

Targeting purine metabolism in ovarian cancer [PDF]

open access: yesJournal of Ovarian Research, 2022
Purine, an abundant substrate in organisms, is a critical raw material for cell proliferation and an important factor for immune regulation. The purine de novo pathway and salvage pathway are tightly regulated by multiple enzymes, and dysfunction in ...
Jingchun Liu   +7 more
doaj   +2 more sources

Antibiotic-induced gut microbiota dysbiosis has a functional impact on purine metabolism [PDF]

open access: yesBMC Microbiology, 2023
Background Dysbiosis of the gut microbiota is closely linked to hyperuricemia. However, the effect of the microbiome on uric acid (UA) metabolism remains unclear.
Xin Liu   +6 more
doaj   +2 more sources

Purine metabolism in plant pathogenic fungi [PDF]

open access: yesFrontiers in Microbiology
In eukaryotic cells, purine metabolism is the way to the production of deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) and plays key roles in various biological processes.
Manli Sun   +3 more
doaj   +2 more sources

Purine Metabolism and Rett Syndrome

open access: yesPediatric Neurology Briefs, 1996
Levels of purine and pyridine nucleotides and their metabolites were determined in erythrocytes and plasma of 31 Rett pattients and 17 age-matched controls at the Departments of Molecular Biology and Child Psychiatry, University of Siena, Children’s ...
J Gordon Millichap
doaj   +4 more sources

Metformin improves HPRT1-targeted purine metabolism and repairs NR4A1-mediated autophagic flux by modulating FoxO1 nucleocytoplasmic shuttling to treat postmenopausal osteoporosis [PDF]

open access: yesCell Death and Disease
Osteoporosis is a major degenerative metabolic bone disease that threatens the life and health of postmenopausal women. Owing to limitations in detection methods and prevention strategy awareness, the purpose of osteoporosis treatment is more to delay ...
Keda Yang   +4 more
doaj   +2 more sources

Purine Metabolism in Acute Cerebral Ischemia

open access: diamondОбщая реаниматология, 2008
Objective: to study the specific features of purine metabolism in clinically significant acute cerebral ischemia. Subjects and materials. Three hundred and fifty patients with the acutest cerebral ischemic stroke were examined.
Ye. V. Oreshnikov   +2 more
doaj   +3 more sources

ON THE METABOLISM OF PURINE

open access: hybridJournal of Biological Chemistry, 1957
Milton P. Gordon   +2 more
openalex   +4 more sources

Resensitizing β‐Lactams by Reprogramming Purine Metabolism in Small Colony Variant for Osteomyelitis Treatment [PDF]

open access: yesAdvanced Science
Small colony variant (SCV) is strongly linked to antibiotic resistance and the persistence of osteomyelitis. However, the intrinsic phenotypic instability of SCV has hindered a thorough investigation of its pathogenic mechanisms.
Tingwang Shi   +11 more
doaj   +2 more sources

Purine metabolism-related genes and immunization in thyroid eye disease were validated using bioinformatics and machine learning [PDF]

open access: yesScientific Reports, 2023
Thyroid eye disease (TED), an autoimmune inflammatory disorder affecting the orbit, exhibits a range of clinical manifestations. While the disease presentation can vary, cases that adhere to a prototypical pattern typically commence with mild symptoms ...
Zixuan Wu   +4 more
doaj   +2 more sources

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