Results 21 to 30 of about 1,551,682 (283)

Purine metabolism regulates DNA repair and therapy resistance in glioblastoma

Nature Communications, 2020
Targeting genotype-independent abnormalities may overcome therapy resistance in glioblastoma despite intratumoral genomic heterogeneity. Here, the authors show that glioblastoma radiation resistance is promoted by purine metabolism and can be overcome by
Weihua Zhou, Yangyang Yao, Andrew J. Scott, Kari Wilder-Romans, Joseph J. Dresser, Christian K. Werner, Hanshi Sun, Drew Pratt, Peter Sajjakulnukit, Shuang G. Zhao, Mary Davis, Barbara S. Nelson, Christopher J. Halbrook, Li Zhang, Francesco Gatto, Yoshie Umemura, Angela K. Walker, Maureen Kachman, Jann N. Sarkaria, Jianping Xiong, Meredith A. Morgan, Alnawaz Rehemtualla, Maria G. Castro, Pedro Lowenstein, Sriram Chandrasekaran, Theodore S. Lawrence, Costas A. Lyssiotis, Daniel R. Wahl   +27 more
doaj   +2 more sources

Purine metabolism promotes radioresistance and is a therapeutic target in glioblastoma

Molecular & Cellular Oncology, 2020
Profound intratumoral genomic heterogeneity has limited the ability of targeted therapies to overcome therapy resistance in glioblastoma. We have defined purine metabolism as a key mediator of DNA repair and radiation resistance in glioblastoma.
Weihua Zhou, Daniel R Wahl
doaj   +2 more sources

HIF-1α-HPRT1 axis promotes tumorigenesis and gefitinib resistance by enhancing purine metabolism in EGFR-mutant lung adenocarcinoma

Journal of Experimental & Clinical Cancer Research
Background The mutations of oncogenic epidermal growth factor receptor (EGFR) is an important cause of lung adenocarcinoma (LUAD) malignance. It has been knowm that metabolic reprogramming is an important hallmark of malignant tumors, and purine ...
Pengyu Geng, Fei Ye, Peng Dou, Chunxiu Hu, Jiarui He, Jinhui Zhao, Qi Li, Miao Bao, Xiangnan Li, Xinyu Liu, Guowang Xu   +10 more
doaj   +2 more sources

Interplay between mTOR and Purine Metabolism Enzymes and Its Relevant Role in Cancer [PDF]

Int J Mol Sci
Tumor cells reprogram their metabolism to meet the increased demand for nucleotides and other molecules necessary for growth and proliferation. In fact, cancer cells are characterized by an increased “de novo” synthesis of purine nucleotides.
Allegrini S, Camici M, Garcia-Gil M, Pesi R, Tozzi M.   +4 more
europepmc   +2 more sources

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis [PDF]

Molecular Oncology
Colorectal cancer (CRC) is widely recognized for its high prevalence and significant mortality rates, and purine metabolism has been serving as a potential therapeutic target.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
doaj   +2 more sources

Microcephaly-associated protein WDR62 supports purine metabolism by interacting with co-chaperone BAG2 [PDF]

The EMBO Journal
Inherited mutations in the spindle pole-associated scaffold protein WDR62 cause autosomal recessive primary microcephaly. Previous research has characterised the roles of WDR62 in the regulation of spindle dynamics, cell division, and brain development ...
Matthew J Morris, Yvonne Y Yeap, Jonathon R Edwards, Chi Chen, Annalisa Paolino, Sebastian G B Furness, S Sean Millard, Julia K Pagan, Laura R Fenlon, Dominic C H Ng   +9 more
doaj   +2 more sources

Disorders of purine biosynthesis metabolism

Molecular Genetics and Metabolism, 2022
Purines are essential molecules that are components of vital biomolecules, such as nucleic acids, coenzymes, signaling molecules, as well as energy transfer molecules. The de novo biosynthesis pathway starts from phosphoribosylpyrophosphate (PRPP) and eventually leads to the synthesis of inosine monophosphate (IMP) by means of 10 sequential steps ...
Dewulf, Joseph P, Marie, Sandrine, Nassogne, Marie-Cécile   +2 more
openaire   +6 more sources

Disorder of purine metabolism in the etiopathogenesis of urate nephrolithiasis

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2023
Urinary stone disease (USD) is a polyetiological urological disease caused by both exogenous and endogenous factors, including hereditary ones. It is characterized by the appearance of stones in the kidneys and urinary tract, and a tendency to relapse ...
S. I. Vorotyntsev, A. I. Bilai, I. M. Bilai   +2 more
doaj   +1 more source

Purine signaling pathway dysfunction in autism spectrum disorders: Evidence from multiple omics data

Frontiers in Molecular Neuroscience, 2023
IntroductionPrevious studies have suggested that the dysregulation of purine metabolism may be associated with autism spectrum disorder (ASD). Here, we adopted metabolomics and transcriptomics to verify and explore the underlying molecular mechanism of ...
Si Dai, Jingjing Lin, Yanting Hou, Xuerong Luo, Yidong Shen, Jianjun Ou   +5 more
doaj   +1 more source

Purine metabolism-related genes and immunization in thyroid eye disease were validated using bioinformatics and machine learning

Scientific Reports, 2023
Thyroid eye disease (TED), an autoimmune inflammatory disorder affecting the orbit, exhibits a range of clinical manifestations. While the disease presentation can vary, cases that adhere to a prototypical pattern typically commence with mild symptoms ...
Zixuan Wu, Yuan Gao, Liyuan Cao, Qinghua Peng, Xiaolei Yao   +4 more
semanticscholar   +1 more source