Results 221 to 230 of about 1,297,457 (342)

Staphylococcus aureus COL: An Atypical Model Strain of MRSA That Exhibits Slow Growth and Antibiotic Tolerance due to a Mutation in PRPP Synthetase

Molecular Microbiology, EarlyView.
COL is an unusual “model” strain of Staphylococcus aureus that exhibits slow growth and multidrug antibiotic tolerance. This phenotype is primarily due to a mutation in Prs, which synthesizes the core metabolite phosphoribosyl pyrophosphate (PRPP). Introduction of the COL Prs allele into the antibiotic‐susceptible strain Newman confers tolerance, while
Claire E. Stevens, Ashley T. Deventer, Paul R. Johnston, Phillip T. Lowe, Alisdair B. Boraston, Joanne K. Hobbs   +5 more
wiley   +1 more source

Single-Cell and Spatial Transcriptomics Explore Purine Metabolism-Related Prognostic Risk Model and Tumor Immune Microenvironment Modulation in Ovarian Cancer. [PDF]

Hum Mutat
Liu Y, Geng R, Zhao S, Yang J, Liu J, Zheng Y, Tang W.   +6 more
europepmc   +1 more source

An HWE‐Family Histidine Kinase Modulates Brucella Cell Envelope Properties and Host Innate Immune Response

Molecular Microbiology, EarlyView.
The HWE‐family histidine kinase PhyK regulates the cell envelope structure of the intracellular pathogen Brucella ovis and affects how the host immune system responds to this bacterium. Deletion of phyK alters bacterial survival in the face of detergent stress and reduces immune activation in infected macrophages.
Xingru Chen, Emily Perez, Eleanor C. Scheeres, Rosemary Northcote, Aretha Fiebig, Andrew J. Olive, Sean Crosson   +6 more
wiley   +1 more source

Purine metabolism in bone marrow microenvironment inhibits hematopoietic stem cell differentiation under microgravity. [PDF]

Stem Cell Res Ther
Liu X, Zhang H, Yan J, Ye P, Wang Y, Zhang N, Tian Z, Liu B, Yang H.   +8 more
europepmc   +1 more source

Cellular view of metabolism: metabolic biomolecular condensates

New Phytologist, EarlyView.
Summary Recent studies across biological systems highlight an important function of biomolecular condensates (hereafter biocondensates) in regulating physiology. Biocondensates are membraneless organelles that compartmentalize cellular processes and allow regulatory control of key biomolecules through their assembly and disassembly. Biocondensates have
Evan V. Saldivar, Sterling Field, Seung Y. Rhee   +2 more
wiley   +1 more source

Bacterial purine metabolism modulates C. elegans development and stress tolerance via DAF-16. [PDF]

FEBS J
Feng M, Gao B, Garcia LR, Sun Q.
europepmc   +1 more source

Lesch-Nyhan Disease and Related Disorders of Purine Metabolism

, 2007
William L. Nyhan
openalex   +1 more source

Differentiation Trajectory of Virus‐Induced Tumour Cells in Rice Revealed by Single‐Cell RNA Sequencing

Plant Biotechnology Journal, EarlyView.
ABSTRACT Many plant viruses trigger abnormal differentiation and development of host cells, causing distinct symptoms. Here, in a single‐cell RNA sequence analysis, we find transcriptional heterogeneity between cells from rice leaf sheaths that are infected with rice black streaked dwarf virus (RBSDV) and from those that are virus‐free.
Nan Wu, Lu Gan, Qingqing Suo, Fei Yang, Wenwen Liu, Xifeng Wang, Huaibing Jin   +6 more
wiley   +1 more source

Uric Acid, the End-Product of Purine Metabolism, Mitigates Tau-Related Abnormalities: Comparison with DOT, a Non-Antibiotic Oxytetracycline Derivative. [PDF]

Biomolecules
Andretto de Mattos B, Tomas-Grau RH, Alves Fernandes TA, González-Lizárraga F, Tourville A, Ciss I, Brunel JM, Chehin R, Lannuzel A, Ferrié L, Raisman-Vozari R, Figadère B, Del Bel E, Michel PP.   +13 more
europepmc   +1 more source

STUDIES OF PURINE METABOLISM

Cold Spring Harbor Symposia on Quantitative Biology, 1948
openaire   +2 more sources