Results 251 to 260 of about 1,394,357 (370)

A member of the gut mycobiota modulates host purine metabolism exacerbating colitis in mice

Science Translational Medicine, 2017
Tyson R. Chiaro, R. Soto, W. Stephens, J. Kubinak, C. Petersen, Lasha Gogokhia, Rickesha S. Bell, J. Delgado, Julio C. Delgado, James Cox, W. Voth, Jessica C. S. Brown, D. Stillman, Ryan M. O’Connell, A. Tebo, A. Tebo, J. Round   +16 more
semanticscholar   +1 more source

On why cancer cells require a great amount of glucose

Quantitative Biology, Volume 14, Issue 2, June 2026.
Abstract The traditional thinking has been that cancer cells require a great amount of glucose to support their rapid growth, but the reality may be different. We have previously demonstrated that all cancer cells in The Cancer Genome Atlas harbor persistent Fenton reactions in their cytosol, which generate OH− ${\text{OH}}^{-}$ and ultimately kill the
Xuechen Mu, Aoran Liu, Rui Shi, Long Xu, Zhenyu Huang, Ye Zhang, Ying Xu   +6 more
wiley   +1 more source

Ultrasound irradiation activates purine metabolism and mitochondrial respiration via the MAPK signaling pathway in myotubes. [PDF]

Biochem Biophys Rep
Ma X, Maeshige N, Yamaguchi A, Fu Y, Xing J, Guo Q, Lin H, Lu F, Kondo H, Fujino H.   +9 more
europepmc   +1 more source

Metabolic‐immune interactions in gastric cancer T cells: A single‐cell atlas for prognostic biomarker identification

Quantitative Biology, Volume 14, Issue 2, June 2026.
Abstract Metabolic alterations and immune dysfunction within the gastric tumor microenvironment critically drive gastric cancer (GC) progression and therapeutic resistance. Although single‐cell RNA sequencing (scRNA‐seq) has unveiled cellular heterogeneity in GC, the metabolic landscapes of tumor cells and their interplay with immune components remain ...
Junjun Liu, Rui Zhao, Guodong Yao, Zhao Liu, Runze Shi, Jingshu Geng, Guanying Liang, Kexin Chen   +7 more
wiley   +1 more source

Metformin‐Mediated Glycaemic Regulation as a Potential Strategy for Breast Cancer Prevention

Cancer Medicine, Volume 15, Issue 2, February 2026.
Metformin (MET), a common antihyperglycemic drug, shows promising anti‐cancer effects in breast cancer (BC). It activates adenosine monophosphate‐activated protein kinase (AMPK), regulating cellular energy and inducing cell cycle arrest, anti‐proliferation, and microenvironment alterations.
Ambulugala Gamage Rajika Greshamali Jinadasa, N. D. Amal Wageesha, Sameera R. Samarakoon, Sagarika Ekanayake, H. M. Kasuni Akalanka   +4 more
wiley   +1 more source

Lnc-TPT1-AS1/CBP/ATIC Axis Mediated Purine Metabolism Activation Promotes Breast Cancer Progression. [PDF]

Cancer Sci
Zhang Y, Zhang H, Li M, Li Y, Wang ZR, Cheng W, Liu Y, Fang Z, Zheng A, Wang J, Ma F.   +10 more
europepmc   +1 more source

Crosstalk Between Intratumoral Microbes and Tumor Immunity: Implications for Tumor Therapy

Cancer Medicine, Volume 15, Issue 2, February 2026.
ABSTRACT Background Emerging studies indicate that microbes are present in tumor cells and immune cells. Intratumoral microbiota (ITM) constitute an important component of the tumor immune microenvironment (TIME) and have an important impact on tumor progression and treatment. Objective Through the general elaboration of ITM represented by bacteria and
Fengxue Li, Lili Qiao, Xinquan Liang, Yingying Zhang, Ning Liang, Jian Xie, Guodong Deng, Yuying Hao, Pingping Hu, Xue Wu, Fangjie Ding, Can Feng, Yiming Mu, Jiandong Zhang   +13 more
wiley   +1 more source

Unveiling purine metabolism dysregulation orchestrated immunosuppression in advanced pancreatic cancer and concentrating on the central role of NT5E. [PDF]

Front Immunol
Zhang J, Zhang X, Wu R, Dong CS.
europepmc   +1 more source

A New View into the Regulation of Purine Metabolism: The Purinosome.

TIBS -Trends in Biochemical Sciences. Regular ed, 2017
Anthony M. Pedley, S. Benkovic
semanticscholar   +1 more source

Distinct Metabolomic Alterations Are Associated With Physical Function, Weight Loss, and Muscle Mass in Men With Cancer

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Background Treatments for cancer cachexia, defined as involuntary weight and muscle mass loss leading to significant functional impairment, remain unavailable partly due to insufficient improvement of clinically meaningful outcomes in current trials.
Lindsey J. Anderson, Lu Xia, Haiming Kerr, Marin Cabrera, Fabien Chu, Jaqueline Rose, Peter C. Wu, Atreya Dash, Sina A. Gharib, Jose M. Garcia   +9 more
wiley   +1 more source